本文選題：帕金森病　切入點：磁共振成像　出處：《放射學實踐》2017年12期 　論文類型：期刊論文

【摘要】：目的:采用基于纖維束示蹤的空間統(tǒng)計方法分析(TBSS)早期帕金森病患者擴散張量成像(DTI)數(shù)據(jù),研究早期帕金森病患者腦白質(zhì)結(jié)構(gòu)損害情況及與運動癥狀的相關性。方法:18例早期帕金森病(PD)患者(Hoehn-Yahr 1~2級)及22例健康志愿者(對照組)行DTI掃描,采用TBSS技術對兩組受試者的DTI數(shù)據(jù)進行分析,比較兩組受試者腦白質(zhì)纖維的部分各向異性(FA)值的差異,及其與帕金森病評估量表(UPDRS-Ⅲ)評分的相關性,測量并比較先發(fā)病側(cè)與對側(cè)大腦白質(zhì)的FA值。結(jié)果:全腦分析顯示:與正常對照組相比,PD組雙側(cè)額頂部、放射冠、胼胝體和扣帶回的腦白質(zhì)FA值明顯減低(P0.05),且其范圍均與UPDRS-Ⅲ評分呈負相關(r=-0.479~-0.736,P0.05);早期PD患者先發(fā)病側(cè)大腦與對側(cè)大腦比較,后放射冠、頂葉及顳葉的腦白質(zhì)FA值的差異有統(tǒng)計學意義(P0.05)。結(jié)論:早期PD患者即可見腦白質(zhì)纖維結(jié)構(gòu)的改變,大腦白質(zhì)損害程度與PD患者運動癥狀有密切聯(lián)系,PD患者腦白質(zhì)損害的部位可能存在一定的順序。
[Abstract]:Objective: to analyze the DTI data of early Parkinson's disease patients with TBSS using spatial statistical method based on fiber tracer. To study the changes of white matter structure in patients with early Parkinson's disease and their correlation with motor symptoms. Methods DTI scans were performed in 18 patients with early Parkinson's disease (PDD) and 22 healthy volunteers (control group) with Hoehn-Yahr grade 1 / 2. The TBSS technique was used to analyze the DTI data of the two groups. The difference of partial anisotropy of white matter fibers between the two groups was compared, and the correlation between the values and the PD RS- 鈪，

本文編號：1628005