本文選題：超聲形態(tài)積分　切入點：卵巢癌　出處：《中華腫瘤防治雜志》2017年04期 　論文類型：期刊論文

【摘要】：目的超聲形態(tài)積分(sonographic morphologic score,SMS)在卵巢癌術(shù)前診斷中具有重要價值,報道較多;而SMS在卵巢癌術(shù)后的應(yīng)用報道較少,作用不明。本研究運用接受器工作特性曲線(receiver operating characteristic curve,ROC)分析比較SMS和CA125及CA199診斷卵巢癌術(shù)后復(fù)發(fā)的價值。方法收集2013-01-01-2015-06-30南通市腫瘤醫(yī)院經(jīng)手術(shù)病理確診為卵巢癌64例患者的術(shù)后臨床資料。所有患者行超聲檢查,計算SMS,檢測血清CA125和CA199;SMS范圍0~10,由腫瘤體積積分和結(jié)構(gòu)積分組成。復(fù)發(fā)診斷標(biāo)準(zhǔn)以臨床檢查、MRI及盆腔腫塊穿刺獲取的病理診斷等綜合判斷。繪制ROC曲線,確定最佳截斷值。結(jié)果 64例患者中,臨床診斷29例腫瘤復(fù)發(fā),SMS平均(5.0±0.3)分。未見復(fù)發(fā)35例,其中21例盆腔未見占位,SMS均為0分;1例炎癥腫塊,SMS 3分;13例淋巴囊腫,SMS平均(2.0±0.4)分。SMS和CA125診斷卵巢癌復(fù)發(fā)的曲線下面積分別為0.848和0.883,差異無統(tǒng)計學(xué)意義,Z=0.24,P=0.66;SMS和CA199的曲線下面積分別為0.872和0.813,差異無統(tǒng)計學(xué)意義,Z=0.48,P=0.26。以5為截斷值,SMS診斷腫瘤復(fù)發(fā)的敏感度、特異度、陽性預(yù)期值和陰性預(yù)期值分別為75.86%、91.43%、88.00%和82.05%。SMS與卵巢癌復(fù)發(fā)診斷存在相關(guān)性,χ~2=30.168 3,P0.001。結(jié)論 SMS與CA125和CA199診斷卵巢癌術(shù)后復(fù)發(fā)的ROC曲線下面積差異無統(tǒng)計學(xué)意義,SMS在卵巢癌復(fù)發(fā)診斷中具有重要價值。
[Abstract]:Objective to evaluate the value of sonographic morphologic scoreography (SMSs) in the preoperative diagnosis of ovarian cancer, and to report more reports on the application of SMS after ovarian cancer surgery. The purpose of this study was to compare the diagnostic value of SMS, CA125 and CA199 for postoperative recurrence of ovarian cancer by receiver operating characteristic curveroc. Methods 64 cases of ovarian cancer diagnosed by operation and pathology in Nantong Cancer Hospital, 2013-01-01-2015-06-30, were collected. Clinical data of patients after operation. All patients were examined by ultrasound. SMSs were calculated, serum CA125 and CA199SMs were measured in the range of 0 ~ 10, which consisted of tumor volume integral and structural integral. Recurrence diagnosis criteria were judged by clinical examination and pathological diagnosis of pelvic mass puncture. ROC curves were plotted. Results among 64 patients, 29 patients with tumor recurrence had an average score of 5.0 鹵0.3, and no recurrence was found in 35 patients. Among them, 21 cases of pelvic space occupying tumor were all 0, 1 case of inflammatory mass SMS3 and 13 cases of lymphoid cyst had an average of 2.0 鹵0.4). The area under the curve of SMS and CA125 for the diagnosis of ovarian cancer recurrence were 0.848 and 0.883, respectively. There was no significant difference between the two groups. The area under line was 0.872 and 0.813, respectively. There was no significant difference between them. The sensitivity of SMS in diagnosis of tumor recurrence was determined by using 5 as truncation value. Specificity, The positive and negative predictive values were 75.86% and 82.05%, respectively. The positive and negative predictive values were correlated with the recurrence diagnosis of ovarian cancer. Conclusion there is no significant difference in the area under the ROC curve between SMS and CA125 and CA199 in the diagnosis of ovarian cancer recurrence after operation. It has important value in diagnosis.
【作者單位】： 南通市腫瘤醫(yī)院影像科;
【分類號】：R445;R737.31

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