發(fā)布時(shí)間：2018-03-06 17:46

  本文選題：多系統(tǒng)萎縮　切入點(diǎn)：擴(kuò)散磁共振成像　出處：《中國(guó)醫(yī)學(xué)影像技術(shù)》2015年09期 　論文類型：期刊論文

【摘要】：目的探討MR DTI參數(shù)對(duì)多系統(tǒng)萎縮(MSA)患者幕下區(qū)域病變的診斷價(jià)值。方法對(duì)8例臨床診斷為MSA患者(MSA組)和10名正常人(對(duì)照組)分別行常規(guī)頭MR和DTI掃描。測(cè)量雙側(cè)小腦中腳(MCP)寬度、腦橋前后徑以及雙側(cè)小腦下腳(ICP)、小腦中腳(MCP)、小腦上腳(SCP)、腦干皮質(zhì)脊髓束(CST)、交叉纖維(CF)、內(nèi)側(cè)丘系(ML)及小腦白質(zhì)的ADC和FA值,并進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果 MSA組雙側(cè)ICP、雙側(cè)MCP、雙側(cè)SCP、右側(cè)ML及雙側(cè)小腦白質(zhì)的FA值顯著低于對(duì)照組;MSA組右側(cè)ICP、雙側(cè)MCP、雙側(cè)SCP、CF、左側(cè)ML及雙側(cè)小腦白質(zhì)的ADC值顯著高于對(duì)照組。MCP的ADC值、FA值與其萎縮程度有相關(guān)性;CST、CF、ML的ADC、FA值與腦橋萎縮程度有相關(guān)性。對(duì)照組、MSA組"十字征"陰性患者、陽(yáng)性患者間ADC值、FA值差異有統(tǒng)計(jì)學(xué)意義。結(jié)論 DTI可活體無(wú)創(chuàng)評(píng)價(jià)MSA幕下區(qū)域腦組織病變,較常規(guī)MRI更敏感地發(fā)現(xiàn)結(jié)構(gòu)異常。
[Abstract]:Objective to evaluate the value of Mr DTI parameters in the diagnosis of subtentorial regional lesions in patients with multisystem atrophy. Methods conventional head Mr and DTI scanning were performed in 8 patients with MSA and 10 normal subjects (control group). The width of MCPs in bilateral cerebellum, The ADC and FA values of the anterior and posterior pons, the bilateral inferior cerebellar peduncle, the middle cerebellar pedunculum, the superior cerebellar peduncle, the corticospinal tract of the brain stem and the spinal tract of the brain stem, the crossed fibers, the medial colliculus, and the white matter of the cerebellum. Results the FA values of bilateral ICP, bilateral MCP, bilateral SCP, right ML and bilateral cerebellar white matter in MSA group were significantly lower than those in control group. The ADC values of bilateral ADC, left ML and bilateral cerebellar white matter were significantly higher than those in control group. There was a correlation between the ADC value of MCP and the degree of atrophy in the control group, and there was a correlation between the value of ADC and the degree of pons atrophy in the control group, while in the control group, the "cross sign" was negative in the control group. Conclusion DTI can be used to evaluate the pathological changes of the subtentorial area of MSA in vivo and to detect structural abnormalities more sensitively than conventional MRI.
【作者單位】： 中國(guó)醫(yī)科大學(xué)附屬第一醫(yī)院放射科;中國(guó)醫(yī)科大學(xué)附屬第一醫(yī)院神經(jīng)內(nèi)科;
【分類號(hào)】：R742;R445.2

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