本文關(guān)鍵詞： 肌骨腫瘤 磁共振成像 灌注加權(quán)成像 血管生成　出處：《臨床放射學(xué)雜志》2015年02期 　論文類型：期刊論文

【摘要】：目的探討動態(tài)增強(qiáng)磁化率對比(DSC)-MR灌注參數(shù)與肌骨腫瘤微血管密度(MVD)之間的相關(guān)性在評價(jià)腫瘤良惡性及生物學(xué)活性方面的價(jià)值。方法對68例原發(fā)性肌骨腫瘤(良性32例,惡性36例)術(shù)前行MRI常規(guī)及DSC-MR灌注成像檢查,分別得到負(fù)性強(qiáng)化積分(NEI)、最大下降斜率(MSD)及平均通過時(shí)間(MTE)灌注參數(shù);術(shù)后對腫瘤病理切片進(jìn)行SP法免疫組織化學(xué)染色,檢測腫瘤MVD,分別統(tǒng)計(jì)各灌注參數(shù)結(jié)果并分析其與MVD之間的相關(guān)性。結(jié)果良性腫瘤MVD為13.4±4.16,惡性腫瘤MVD為22.46±5.76,兩者差異有統(tǒng)計(jì)學(xué)意義(t=7.344,P0.01)。經(jīng)相關(guān)分析得出NEI、MSD及MTE與MVD均有相關(guān)性,其中NEI、MSD呈顯著正相關(guān),r值分別為0.623、0.601,MTE與MVD呈低度線性相關(guān),r值為0.274。結(jié)論 MR部分灌注參數(shù)與腫瘤微血管生成有顯著相關(guān)性,提示動態(tài)磁敏感增強(qiáng)可以評價(jià)腫瘤血管化及血管生成情況,為臨床術(shù)前及預(yù)后提供更為可靠的病理生理學(xué)信息。
[Abstract]:Objective to evaluate the correlation between DSC-Mr perfusion parameters and microvessel density (MVD) of bone tumors by dynamic enhanced magnetization. Methods Sixty-eight patients with primary musculoskeletal neoplasms (benign 32 cases) were enrolled in this study. MRI routine and DSC-MR perfusion imaging were performed in 36 cases of malignant tumor before operation, and the perfusion parameters of negative enhanced integral (NEI), maximum descending slope (MSD) and mean transit time (MTE) were obtained respectively, and the pathological sections of the tumor were stained with SP immunohistochemical staining after operation. Results the MVD of benign tumor was 13.4 鹵4.16, the MVD of malignant tumor was 22.46 鹵5.76, the difference between them was statistically significant (P 0.01). There was a significant positive correlation between MVD and MVD. Conclusion there is a significant correlation between Mr perfusion parameters and tumor microangiogenesis, and a low linear correlation between MVD and Mr is 0.274.Conclusion there is a significant correlation between Mr partial perfusion parameters and tumor microangiogenesis. The results suggest that dynamic magnetic sensitivity enhancement can evaluate tumor vascularization and angiogenesis and provide more reliable pathophysiological information for clinical preoperation and prognosis.
【作者單位】： 寧夏醫(yī)科大學(xué);鄭州大學(xué)附屬洛陽市中心醫(yī)院介入科;第四軍醫(yī)大學(xué)唐都醫(yī)院放射科;寧夏醫(yī)科大學(xué)總醫(yī)院放射科;
【分類號】：R738.1;R445.2

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1 鄒文遠(yuǎn);李勝;劉源源;田林;劉s，

本文編號：1545767