本文關(guān)鍵詞： 缺氧 腦血管循環(huán) 磁共振成像 灌注成像 動脈自旋標(biāo)記 圖像處理 計算機(jī)輔助 高海拔　出處：《中國醫(yī)學(xué)影像學(xué)雜志》2015年12期 　論文類型：期刊論文

【摘要】：目的平原人口在急進(jìn)高原時因低壓缺氧會發(fā)生腦血流量改變。本研究利用動脈自旋標(biāo)記技術(shù)測量平原受試者在平原及高海拔地區(qū)腦血流量值,進(jìn)一步了解高原低壓缺氧環(huán)境下腦血流量的動態(tài)變化。資料與方法 6名平原健康受試者快速進(jìn)駐高原并停留5 d,然后返回平原。掃描在平原和高原兩地進(jìn)行,試驗儀器為2臺同一機(jī)型的3.0T MR掃描儀。共進(jìn)行8次MRI掃描,所有掃描參數(shù)一致,觀察受試者腦血流量值的變化。結(jié)果受試者快速進(jìn)駐高原后,腦血流量值較平原腦血流量值明顯上升,并達(dá)到一定的峰值,進(jìn)駐高原第1天全腦、灰質(zhì)及白質(zhì)區(qū)域的腦血流量值與平原腦血流量值相比,差異有統(tǒng)計學(xué)意義(P0.05);高原停留第2天,腦血流量值有一定程度的下降,第3天稍有上升,然后腦血流量值持續(xù)下降至低于進(jìn)駐高原前在平原的腦血流量值;回到平原1周后,全腦、灰質(zhì)、白質(zhì)區(qū)域的腦血流量值仍低于進(jìn)駐高原前在平原的腦血流量值,差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論平原人口快速進(jìn)駐高原后,腦血流量會有一定程度的升高,隨著高原習(xí)服,腦血流量逐漸降低至低于平原腦血流量水平。
[Abstract]:Objective to study the changes of cerebral blood flow (CBF) in plain population at high altitude due to hypobaric hypoxia. In this study, cerebral blood flow (CBF) of plain subjects in plain and high altitude was measured by arterial spin labeling technique. Data and methods data and methods 6 healthy subjects from plain to plateau were stationed at high altitude for 5 days and then returned to plain. The scans were performed in both plain and plateau. Two 3.0T Mr scanners of the same type were used in the experiment. Eight MRI scans were performed. All the scanning parameters were the same, and the changes of cerebral blood flow were observed. The cerebral blood flow (CBF) value of the whole brain, gray matter and white matter areas was significantly higher than that of the plain area and reached a certain peak value, compared with the plain cerebral blood flow value on the first day of entering the plateau. The difference was statistically significant (P 0.05). After staying at high altitude for the second day, the cerebral blood flow (CBF) decreased to a certain extent, then increased slightly on the 3rd day, then it continued to decrease to a level lower than that in the plain before entering the plateau, and 1 week after returning to the plain, The cerebral blood flow in the whole brain, gray matter and white matter areas was still lower than that in the plain before entering the plateau, and the difference was statistically significant (P 0.05). Conclusion the cerebral blood flow will increase to a certain extent after the rapid entry of the population of the plain into the plateau. With acclimatization at high altitude, cerebral blood flow decreased gradually to lower than plain cerebral blood flow.
【作者單位】： 解放軍總醫(yī)院放射診斷科;西藏軍區(qū)總醫(yī)院放射科;南開大學(xué)醫(yī)學(xué)院;通用電氣(中國)醫(yī)療集團(tuán)MR影像研究中心;
【分類號】：R445.2;R743

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 鄭罡;王利;趙鐵柱;李強(qiáng);潘之穎;盧光明;;動脈自旋標(biāo)記技術(shù)及其衍生技術(shù)[J];生物物理學(xué)報;2012年12期

2 倪萍;張英魁;史凱寧;趙希剛;王小燕;吳博;陳自謙;;全腦3D動脈自旋標(biāo)記成像及其在顱內(nèi)腫瘤病變中的應(yīng)用[J];中國醫(yī)療設(shè)備;2013年10期

3 霍英松;周海燕;;動脈自旋標(biāo)記在成人中樞神經(jīng)系統(tǒng)疾病中的應(yīng)用[J];實用臨床醫(yī)學(xué);2014年02期

4 霍英松;周海燕;;動脈自旋標(biāo)記在小兒中樞神經(jīng)系統(tǒng)檢查中的應(yīng)用[J];實用臨床醫(yī)學(xué);2014年03期

5 黃浩哲;李文濤;;動脈自旋標(biāo)記技術(shù)的研究進(jìn)展[J];中國癌癥雜志;2013年11期

6 王建偉;施海彬;劉圣;王敏;魯珊珊;祖慶泉;;反轉(zhuǎn)恢復(fù)時間對動脈自旋標(biāo)記技術(shù)腦灌注成像的影響[J];江蘇醫(yī)藥;2012年06期

7 王利;鄭罡;趙鐵柱;郭超;李林;盧光明;;動脈自旋標(biāo)記技術(shù)在腦部疾病中的臨床應(yīng)用[J];生物醫(yī)學(xué)工程學(xué)雜志;2013年01期

8 朱記超;婁明武;張方t，

本文編號：1508566