本文關鍵詞： 前列腺癌 慢性前列腺炎 超聲血流動力學 微血管密度　出處：《廣西醫(yī)科大學》2014年碩士論文　論文類型：學位論文

【摘要】：目的：本研究旨在通過經直腸彩色多普勒超聲對前列腺可疑病灶區(qū)血流動力學變化的觀察,并結合與病理微血管密度(microvascular denstity,MVD)的免疫組化觀察,探討經直腸彩色多普勒超聲鑒別診斷前列腺癌和慢性前列腺炎的診斷價值。 方法：收集臨床疑為前列腺癌患者共61例,經直腸超聲掃查前列腺,檢測前列腺可疑病灶區(qū)血流動力學指數(shù)(Vs、Vd、PI、RI),并進行血運分級(0～3級)。并于超聲引導下行前列腺穿刺,獲取病理結果證實為前列腺癌38例,慢性前列腺炎23例。點陣列包埋、石蠟切片行HE染色,經病理醫(yī)師診斷,用CD34單克隆抗體對前列腺活檢組織行免疫組織化學染色,采用Weinder方法對CD34標記的微血管密度進行定量計數(shù)。 結果：前列腺癌組病灶區(qū)血流動力學指數(shù)(Vs、PI、RI)及血運分級明顯高于慢性前列腺炎組(P0.05)；Vs、PI、RI各指標均在前列腺癌(C+D)期和(A+B)期、前列腺癌Gleason評分分為≥7分高Gleason評分組和7分低Gleason評分組兩組中比較有差異性(P均0.05)。血流動力學指數(shù)Vd于各組比較中均無明顯差異(P0.05)。MVD計數(shù)在前列腺癌組和慢性前列腺炎組分別為46.70±13.87、34.38±7.28(P0.05)。MVD計數(shù)在前列腺癌(C+D)期和(A+B)期分別為56.99±12.85、39.97±10.21(P0.05)；在前列腺癌高Gleason評分組和低Gleason評分組分別為53.79±13.30、36.96±7.24(P0.05)。前列腺癌病灶區(qū)的血流動力學指數(shù)(Vs、PI、RI)及血運分級與前列腺癌組織MVD呈顯著正相關(P0.05)。 結論：經直腸彩色多普勒超聲影像顯示的前列腺癌血流動力學指數(shù)(Vs、PI、RI)和血運分級能較好地反映腫瘤組織內微血管的變化,且前列腺癌組可疑病灶或血流豐富區(qū)血流動力學指數(shù)(Vs、PI、RI)及血運分級明顯高于慢性前列腺炎組,可作為兩者鑒別診斷的有用指標。
[Abstract]:Objective: to observe the changes of hemodynamics in the suspected lesion area of prostate by transrectal color Doppler ultrasound and to observe the microvascular denstitystitystitystitystitystitystitystityus microvascular VDD by immunohistochemistry. To evaluate the diagnostic value of transrectal color Doppler ultrasound in the differential diagnosis of prostate cancer and chronic prostatitis. Methods: a total of 61 patients with suspected prostate cancer were collected. The prostate was examined by transrectal ultrasound, and the hemodynamic index of the suspected lesions was detected. Pathological results were obtained from 38 cases of prostate cancer and 23 cases of chronic prostatitis. The specimens were embedded with dot array and stained with HE on paraffin sections. The biopsy tissues were stained with CD34 monoclonal antibody by immunohistochemical staining after being diagnosed by pathologist. The microvessel density (MVD) labeled with CD34 was counted quantitatively by Weinder method. Results: the regional hemodynamic index (Pi) and the grade of blood circulation in prostate cancer group were significantly higher than those in chronic prostatitis group (P 0.05). The Gleason score of prostate cancer was divided into two groups: high score (鈮，

本文編號：1497117