本文關(guān)鍵詞： 肝腫瘤灌注 肝動脈 肝動脈化療栓塞 彩色數(shù)字減影血管造影 灌注減少　出處：《介入放射學(xué)雜志》2017年04期 　論文類型：期刊論文

【摘要】：目的探究彩色編碼數(shù)字減影血管造影(ccDSA)在TACE術(shù)中對肝腫瘤灌注的即刻變化進(jìn)行定量評測。方法回顧性研究了35例TACE治療肝細(xì)胞癌病例。TACE術(shù)前后用相同參數(shù)采集二維數(shù)字減影血管造影(2D-DSA)。圖像序列均經(jīng)二維ccDSA(2D-ccDSA)進(jìn)行后處理。在ccDSA圖像上測量感興趣區(qū)域(ROI),得到時間密度曲線(time-contrast-intensity CI[t]),并獲取腫瘤血供時間(TBST),曲線下面積(AUC)、最大強化值(CI-Peak)和最大上升斜率(MS)這些灌注參數(shù)來分析評估TACE前后順行血流和腫瘤染色減少的程度。并對上述參數(shù)與主觀血管造影栓塞終點(SACE)標(biāo)準(zhǔn)和臨床結(jié)果之間的關(guān)系進(jìn)行分析。結(jié)果 TACE前后灌注參數(shù)的比較有顯著差異。AUC和CI-Peak在TACE術(shù)后大幅下降。TBST在術(shù)后較之術(shù)前有顯著延遲。灌注減少30%~40%相當(dāng)于SACEⅢ級,灌注減少60%~70%相當(dāng)于SACEⅣ級。結(jié)論 2D-ccDSA可以客觀地量化評估TACE術(shù)對肝腫瘤血流灌注的影響,為TACE術(shù)提供了定量評價動脈血流停滯程度和腫瘤染色減少的指標(biāo)。
[Abstract]:Objective to explore the color coded digital subtraction angiography (CCDSA). Methods 35 cases of hepatocellular carcinoma treated with TACE were retrospectively studied before and after the operation. The same parameters were used to collect 2D subtraction blood. Tube angiography (. 2D-DSA.Image sequences were all processed by 2D ccDSA-2D-ccDSA. the region of interest (ROI) was measured on ccDSA images. The time-contrast-intensity CI of time-density curve is obtained. [T], and obtained the tumor blood supply time (TBSTT, area under the curve AUC). Maximum reinforcement value (CI-Peak) and maximum rise slope (MSM). These perfusion parameters were used to analyze and evaluate the degree of the decrease of anterograde blood flow and tumor staining before and after TACE. Analysis of the relationship between criteria and clinical outcomes. Results. There was significant difference in perfusion parameters before and after TACE. AUC and CI-Peak decreased significantly after TACE. TBST was significantly delayed after TACE. The perfusion was reduced by 30% and 40%. It is equivalent to SACE 鈪，

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