本文關(guān)鍵詞： 動(dòng)態(tài)對(duì)比增強(qiáng)磁共振成像 膠質(zhì)瘤 容積轉(zhuǎn)運(yùn)常數(shù) 血管外細(xì)胞外間隙　出處：《第三軍醫(yī)大學(xué)學(xué)報(bào)》2015年23期 　論文類型：期刊論文

【摘要】：目的探討動(dòng)態(tài)對(duì)比增強(qiáng)磁共振成像對(duì)腦膠質(zhì)瘤微血管通透性的定量評(píng)價(jià)價(jià)值。方法總共38例病理證實(shí)膠質(zhì)瘤患者使用3.0T磁共振儀器進(jìn)行包括動(dòng)態(tài)對(duì)比增強(qiáng)的磁共振檢查,獲得膠質(zhì)瘤容積轉(zhuǎn)運(yùn)常數(shù)(Ktrans)和血管外細(xì)胞外間隙容積比(Ve)的最大值。不同級(jí)別膠質(zhì)瘤的Ktrans值和Ve值的差異;Ktrans值、Ve值和膠質(zhì)瘤分級(jí)之間的相關(guān)性進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果Ⅱ級(jí)膠質(zhì)瘤Ktrans值(0.028±0.011 min-1)與Ve值(0.081±0.044)均低于Ⅲ級(jí)(0.105±0.025 min-1,0.456±0.079)和Ⅳ級(jí)(0.138±0.053 min-1,0.512±0.112),差異具有統(tǒng)計(jì)學(xué)意義(P0.01),而Ⅲ級(jí)和Ⅳ級(jí)之間差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。Ktrans值、Ve值和膠質(zhì)瘤分級(jí),Ktrans值和Ve值均呈顯著正相關(guān)(P0.001)。結(jié)論動(dòng)態(tài)對(duì)比增強(qiáng)磁共振成像可以定量評(píng)價(jià)腦膠質(zhì)瘤微血管通透性并可用于膠質(zhì)瘤術(shù)前分級(jí)。
[Abstract]:Objective to evaluate the value of dynamic contrast enhanced magnetic resonance imaging in quantitative evaluation of microvascular permeability in gliomas. Methods A total of 38 patients with pathologically proved gliomas were performed with 3.0T MRI instrument including dynamic contrast enhancement. Strong MRI. The maximum values of volume transport constant (Ktransa) and extracellular intercellular volume ratio (ECV) of gliomas were obtained. The differences of Ktrans and ve values in gliomas of different grades were obtained. Ktrans value. Results the Ktrans value of grade 鈪，

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