本文關(guān)鍵詞：慢性丘腦梗死患者全腦灰質(zhì)體積改變及與認(rèn)知功能減退的關(guān)系　出處：《中國醫(yī)學(xué)影像技術(shù)》2016年05期 　論文類型：期刊論文

  更多相關(guān)文章： 丘腦 腦梗死 灰質(zhì) 認(rèn)知功能 磁共振成像

【摘要】：目的探討慢性丘腦梗死患者全腦灰質(zhì)體積改變及與認(rèn)知功能減退的關(guān)系。方法對(duì)26例慢性丘腦梗死患者(梗死組)和29名健康志愿者(對(duì)照組)進(jìn)行神經(jīng)心理學(xué)評(píng)價(jià)及MR掃描。分別計(jì)算全腦灰質(zhì)、白質(zhì)、丘腦梗死體積,并進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果與對(duì)照組比較,梗死組簡易精神狀態(tài)檢查量表(MMSE)評(píng)分、短延遲回憶、長延遲回憶、再確認(rèn)及圖形回憶評(píng)分均明顯降低(P均0.05);梗死組全腦灰質(zhì)體積與對(duì)照組比較明顯減小[梗死組:(774 291.49±42 370.85)mm~3,對(duì)照組(802 999.21±37 075.84)mm~3,t=2.442,P=0.018]。梗死組全腦白質(zhì)體積與對(duì)照組比較,差異無統(tǒng)計(jì)學(xué)意義[(705 587.51±32 886.53)mm~3,(717 580.47±31 911.05)mm3,t=1.634,P=0.108]。梗死組全腦灰質(zhì)體積與MMSE評(píng)分及圖形回憶評(píng)分呈中度正相關(guān)(r=0.491、0.427,P=0.017、0.042);全腦灰質(zhì)體積與短延遲回憶、長延遲回憶、再確認(rèn)評(píng)分均無相關(guān)性(P均0.05);丘腦梗死體積與全腦灰質(zhì)體積、MMSE評(píng)分、短延遲回憶、長延遲回憶、再確認(rèn)及圖形回憶評(píng)分均無相關(guān)性(P均0.05)。結(jié)論慢性丘腦梗死患者全腦灰質(zhì)體積減小,可能是其認(rèn)知功能減退的原因。
[Abstract]:Objective to investigate the changes of global gray matter volume in patients with chronic thalamic infarction and its relationship with cognitive impairment. Methods 26 patients with chronic thalamic infarction (infarction group) and 29 healthy volunteers (control group) were enrolled in this study. Neuropsychological evaluation and Mr scan were performed. The gray matter of the whole brain was calculated. Results compared with the control group, the infarct volume of white matter and thalamus was statistically analyzed. Results compared with the control group, the MMSE score, short delayed recall and long delayed recall were found in the infarct group. The scores of reconfirmation and pattern recall were significantly decreased (P < 0.05). Compared with the control group, the whole brain gray matter volume in the infarct group decreased significantly. [In the infarct group, 774 291.49 鹵42 370.85 mm / min, and in the control group 802 999.21 鹵37 075.84 mm / min respectively. There was no significant difference in white matter volume between the infarct group and the control group. [717 580.47 鹵31 911.05 鹵31 911.05 mm ~ (3) t ~ (1.634). The gray matter volume of the whole brain was positively correlated with the MMSE score and the pattern recall score in the infarcted group (P < 0. 491 / 0. 427, P < 0. 017 ~ 0. 042). The whole brain gray matter volume had no correlation with short delayed recall, long delayed recall and reconfirmation score (P < 0.05). The infarct volume of thalamus and the whole brain gray matter volume were evaluated by MMSE score, short delayed recall and long delayed recall. There was no correlation between reconfirmation and pattern recall score (P < 0.05). Conclusion the decrease of global gray matter volume in patients with chronic thalamic infarction may be the cause of cognitive impairment.
【作者單位】： 重慶醫(yī)科大學(xué)附屬第一醫(yī)院放射科;川北醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)院解剖教研室;
【基金】：國家臨床重點(diǎn)專科建設(shè)項(xiàng)目(國衛(wèi)辦醫(yī)函[2013]544號(hào))
【分類號(hào)】：R743.33;R445.2
【正文快照】： ±32 886.53)mm3,(717 580.47±31 911.05)mm3,t=1.634,P=0.108]。梗死組全腦灰質(zhì)體積與MMSE評(píng)分及圖形回憶評(píng)分呈中度正相關(guān)(r=0.491、0.427,P=0.017、0.042);全腦灰質(zhì)體積與短延遲回憶、長延遲回憶、再確認(rèn)評(píng)分均無相關(guān)性(P均0.05);丘腦梗死體積與全腦灰質(zhì)體積、MMSE評(píng)分、

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