本文關(guān)鍵詞：擴散加權(quán)成像體素內(nèi)不相干運動模型參數(shù)與乳腺癌預(yù)后因素及分子亞型的相關(guān)性　出處：《中國醫(yī)學影像技術(shù)》2016年03期 　論文類型：期刊論文

  更多相關(guān)文章： 擴散磁共振成像 乳腺腫瘤 體素內(nèi)不相干運動 預(yù)后因素 分子亞型

【摘要】：目的探討DWI體素內(nèi)不相干運動(IVIM)模型參數(shù)與乳腺癌預(yù)后因素及分子亞型的相關(guān)性。方法收集經(jīng)病理證實的110例乳腺癌患者,所有患者在手術(shù)或穿刺活檢前均行多b值DWI掃描。采用GE后處理工作站生成IVIM模型參數(shù)D、D*和f值,分析各參數(shù)與預(yù)后因素及分子亞型間的相關(guān)性。結(jié)果高侵襲性病灶D值低于低侵襲性者(P0.01),f值高于低侵襲性者(P0.01)。孕激素受體(PR)陽性病灶的D值低于陰性者(P=0.042)。人類表皮生長因子受體(HER-2)高表達病灶的D和D*值均高于低表達者(P=0.001、0.033);HER-2高表達型病灶的D值明顯高于Luminal型和三陰性型(P均0.05)。D值與病理分級、PR表達呈負相關(guān)(r=-0.535、-0.192,P均0.05),與HER-2表達呈正相關(guān)(r=0.304,P=0.001);D*值與HER-2表達呈正相關(guān)(r=0.200,P=0.033)。結(jié)論 DWI的IVIM模型參數(shù)與乳腺癌的病理分級、PR及HER-2表達存在相關(guān)性,D值具有鑒別不同分子亞型乳腺癌的潛在價值。
[Abstract]:Objective to investigate the correlation between the parameters of the incoherent motion (IVIM) model of DWI voxel and the prognostic factors and molecular subtypes of breast cancer. Methods 110 cases of breast cancer confirmed by pathology were collected, and all patients underwent multiple B DWI scan before and before the operation or biopsy. The IVIM model parameters D, D* and F were generated by the GE post processing workstation, and the correlation between the parameters and the prognostic factors and the molecular subtypes was analyzed. Results the D values of high invasive lesions were lower than those of low invasiveness (P0.01), and the value of F was higher than that of low invasiveness (P0.01). The D value of progesterone receptor (PR) positive focus was lower than that of the negative one (P=0.042). The D and D* values of high expression of human epidermal growth factor receptor (HER-2) were higher than those of low expression (P=0.001, 0.033). The D values of HER-2 high expression lesions were significantly higher than those of Luminal and three negative (P 0.05). There was a negative correlation between D value and pathological grade and PR expression (r=-0.535, -0.192, P all 0.05), which was positively correlated with HER-2 expression (r=0.304, P=0.001), and D* value was positively correlated with HER-2 expression (r=0.200, D*). Conclusion the IVIM model parameters of DWI are correlated with the pathological grading, PR and HER-2 expression of breast cancer. D value has potential value in differentiating breast cancer from different molecular subtypes.
【作者單位】： 北京協(xié)和醫(yī)學院中國醫(yī)學科學院腫瘤醫(yī)院影像診斷科;
【基金】：國家重點基礎(chǔ)研究計劃(973計劃) 國家科技重大專項基金(2014CB744505)
【分類號】：R445.2;R737.9
【正文快照】： 乳腺癌的臨床特征、受體狀態(tài)、分子亞型不同使其表現(xiàn)出不同的生物學行為、治療反應(yīng)及預(yù)后[1]。與乳腺癌相關(guān)的預(yù)后因素有腫瘤大小、病理分級、腋窩淋巴結(jié)轉(zhuǎn)移狀況、雌激素受體(estrogen receptor,ER)、孕激素受體(progesterone receptor,PR),人類表皮生長因子受體(human epide，

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