肺炎支原體肺炎患兒出現(xiàn)肺炎支原體血癥的調(diào)查研究
發(fā)布時(shí)間:2022-01-05 13:11
研究背影:肺炎支原體是引起世界范圍內(nèi)兒童和青年人社區(qū)獲得性肺炎(CAP)最常見(jiàn)的病原體之一,其在各個(gè)年齡組都可引起上呼吸道和下呼吸道感染,可占5歲以上兒童CAP的50%以上。支原體肺炎在全年都可爆發(fā),并且與地理區(qū)域,氣候和季節(jié)無(wú)顯著相關(guān),可在大范圍的社區(qū)中流行,且經(jīng)常不被發(fā)現(xiàn),或者很晚才被發(fā)現(xiàn)。在大型或小型社區(qū)進(jìn)行長(zhǎng)期流行病學(xué)研究和地理監(jiān)測(cè)后,據(jù)報(bào)道肺炎支原體每4-7年就會(huì)出現(xiàn)一次循環(huán)性流行。肺炎支原體感染是散發(fā)性的,持續(xù)時(shí)間長(zhǎng),流行間隔時(shí)間不定。肺炎支原體流行時(shí)間延長(zhǎng)主要是由于其潛伏期長(zhǎng)(長(zhǎng)達(dá)3周),以及微生物在呼吸道中持續(xù)時(shí)間延長(zhǎng)所致;颊呒词乖跓o(wú)癥狀的情況下仍可攜帶肺炎支原體,并且長(zhǎng)時(shí)間排出肺炎支原體。因此,在長(zhǎng)時(shí)間內(nèi),仍有這種無(wú)癥狀的攜帶者傳播疾病的可能性。肺炎支原體是一類能在無(wú)生命培養(yǎng)基中自我復(fù)制的最小、最簡(jiǎn)單的原核細(xì)胞,沒(méi)有細(xì)胞壁。該生物呈多行性,長(zhǎng)1-2μm,寬0.1-0.2μm。其頂端結(jié)構(gòu)有助于肺炎支原體附著于呼吸道上皮細(xì)胞,也是肺炎支原體的靶細(xì)胞。由于這些微生物能夠在宿主細(xì)胞外生存,因此它們被認(rèn)為是自由生活的生命形式。支原體的基因組大小和菌體維度較小,限制了菌體合成穩(wěn)...
【文章來(lái)源】:吉林大學(xué)吉林省 211工程院校 985工程院校 教育部直屬院校
【文章頁(yè)數(shù)】:60 頁(yè)
【學(xué)位級(jí)別】:碩士
【文章目錄】:
中文摘要
abstract
Abbreviations
Chapter 1 Introduction
1.1 Definition
1.2 Mycoplasma Pneumoniae infection Epidemiology
1.2.1 Prevalence of MP infection
1.2.2 Morbidity and mortality
1.3 Pathogenesis
1.3.1 Microbiological characteristics of M. pneumoniae
1.3.2 Direct damage mechanism
1.3.3 Interaction with host immune cells
1.3.4 Pathogenesis of Extra-pulmonary manifestation (Hematogenous spread)
1.4 Clinical features
1.5 Diagnostic tests
1.5.1 Laboratory Studies
1.5.2 Imaging Studies
1.6 Treatment
1.7 Prognosis
Chapter 2 Aim and objectives of the study
Chapter 3 Materials and methods
3.1 Study population
3.2 Inclusion Criteria
3.3 Exclusion criteria
3.4 Methodology
3.5 Statistical analysis
Chapter 4 Results
Chapter 5 Discussion
Chapter 6 Conclusion
References
Supervisor introduction
Author's Introduction
ACKNOWLEDGEMENTS
本文編號(hào):3570410
【文章來(lái)源】:吉林大學(xué)吉林省 211工程院校 985工程院校 教育部直屬院校
【文章頁(yè)數(shù)】:60 頁(yè)
【學(xué)位級(jí)別】:碩士
【文章目錄】:
中文摘要
abstract
Abbreviations
Chapter 1 Introduction
1.1 Definition
1.2 Mycoplasma Pneumoniae infection Epidemiology
1.2.1 Prevalence of MP infection
1.2.2 Morbidity and mortality
1.3 Pathogenesis
1.3.1 Microbiological characteristics of M. pneumoniae
1.3.2 Direct damage mechanism
1.3.3 Interaction with host immune cells
1.3.4 Pathogenesis of Extra-pulmonary manifestation (Hematogenous spread)
1.4 Clinical features
1.5 Diagnostic tests
1.5.1 Laboratory Studies
1.5.2 Imaging Studies
1.6 Treatment
1.7 Prognosis
Chapter 2 Aim and objectives of the study
Chapter 3 Materials and methods
3.1 Study population
3.2 Inclusion Criteria
3.3 Exclusion criteria
3.4 Methodology
3.5 Statistical analysis
Chapter 4 Results
Chapter 5 Discussion
Chapter 6 Conclusion
References
Supervisor introduction
Author's Introduction
ACKNOWLEDGEMENTS
本文編號(hào):3570410
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