促紅細(xì)胞生成素結(jié)合高壓氧對(duì)缺氧缺血性腦病患兒神經(jīng)功能恢復(fù)和腦組織代謝的影響
[Abstract]:Aim: to investigate the effects of erythropoietin (EPO) combined with hyperbaric oxygen (HBO) on neural function recovery and brain metabolism in children with hypoxic ischemic encephalopathy (HIE). Methods: 47 children with HIE from September 2012 to April 2015 were randomly divided into observation group (n = 25) and control group (n = 22). The two groups were treated with routine supportive therapy, such as reducing intracranial pressure, correcting acidosis, maintaining electrolyte balance and controlling convulsion. Children in the control group were treated with hyperbaric oxygen, and treated with hyperbaric oxygen for 15 min, oxygen inhalation for 30 min, and decompression for 15 min,qd;. In the observation group, the patients in the control group were given 200 U / kg recombinant human propofol injection (CHO cells) for the first time, subcutaneously for the first time, intravenous injection for the second time, and qd. for the second time. The two groups were treated continuously for 10 days. (NBNA) score, recovery time of nerve reflex, recovery time of consciousness and (MBP), S100B protein of serum neuron-specific enolase (NSE), myelin basic protein were measured before and after treatment, and adverse reactions were recorded. Results: before treatment, there was no significant difference in NBNA score and serum NSE,MBP,S100B protein level between the two groups (P0.05). 5 days after treatment, the NBNA scores of the two groups were significantly higher than those of the control group, and the levels of serum NSE and S100B protein in the observation group were significantly higher than those in the control group (P0.05), and the levels of serum NSE and S100B protein in the two groups were significantly lower than those before treatment. And the observation group was significantly lower than the control group in the same period, the difference was statistically significant (P0.05). At 5 days after treatment, the serum MBP level in the two groups was significantly higher than that before treatment (P0.05), but there was no significant difference between the two groups (P0.05), 10 days after treatment, the serum MBP level of the two groups was significantly lower than that before treatment. The observation group was significantly lower than the control group, the difference was statistically significant (P0.05). After treatment, the nerve reflex recovery time and consciousness recovery time in the observation group were significantly shorter than those in the control group, the difference was statistically significant (P0.05). The incidence of adverse reactions in the observation group (8.00%) was not significantly different from that in the control group (9.09%) (P0.05). Conclusion: Erythropoietin combined with hyperbaric oxygen therapy can effectively promote the recovery of neural function and improve brain metabolism in children with HIE,.
【作者單位】： 河北醫(yī)科大學(xué)第二醫(yī)院藥學(xué)部;河北醫(yī)科大學(xué)第二醫(yī)院神經(jīng)內(nèi)科;
【分類(lèi)號(hào)】：R742
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