本文選題：-羥孕酮 + 新生兒　； 參考：《中國現(xiàn)代醫(yī)學(xué)雜志》2017年22期

【摘要】：目的探討新生兒血清17-羥孕酮(17-OHP)濃度的影響因素。方法選取2014年1月-2015年12月在西南醫(yī)科大學(xué)附屬醫(yī)院分娩的1 585例新生兒作為研究對象,所有新生兒均排除先天性腎上腺皮質(zhì)增生癥者。采用時間分辨熒光免疫分析法檢測17-OHP濃度,比較不同性別、胎齡、出生體重、分娩方法、胎兒數(shù)量、采血日齡、血糖水平、血p H值、有無出現(xiàn)感染、窒息、溶血性黃疸等特征的新生兒血清17-OHP濃度,采用多元線性回歸來分析各臨床特征與血清17-OHP濃度的關(guān)系。結(jié)果全部新生兒的血清17-OHP濃度為0~136.8 nmol/L,平均(16.68±6.83)nmol/L。胎齡為≤28周、29~32周、33~36周、37~41周、≥42周的新生兒血17-OHP的濃度分別為(24.23±2.18)、(22.34±3.23)、(18.56±4.54)、(16.10±5.72)及(14.18±2.56)nmol/L,極低出生體重兒、低出生體重兒、正常出生體重兒、巨大兒的新生兒血17-OHP的濃度分別為(23.87±2.25)、(21.84±3.36)、(16.17±6.08)及(14.43±3.18)nmol/L,各組比較差異有統(tǒng)計學(xué)意義(P0.05)。多元線性回歸結(jié)果表明,17-OHP濃度與多個因素有關(guān),按作用從大到小依次為胎齡、出生體重、血p H值、血糖、窒息、感染、采血日齡、溶血性黃疸、分娩方法、胎兒數(shù)量。結(jié)論新生兒血清17-OHP的濃度受到胎齡、出生體重、酸堿平衡、血糖水平等多個因素的影響,故臨床上要全面關(guān)注這些因素來綜合判斷血17-OHP的水平。
[Abstract]:Objective to investigate the influencing factors of 17-hydroxyprogesterone (17-OHP) concentration in neonatal serum. Methods from January 2014 to December 2015, 1 585 newborns who were delivered in the affiliated Hospital of Southwest Medical University were selected as study objects. All the newborns were excluded from congenital adrenocortical hyperplasia. The concentration of 17-OHP was detected by time-resolved fluorescence immunoassay (TLIA). The sex, gestational age, birth weight, delivery method, number of fetuses, age of blood collection, blood glucose level, blood pH value, infection and asphyxia were compared. Multivariate linear regression was used to analyze the relationship between the clinical characteristics and serum 17-OHP concentration in neonates with hemolytic jaundice. Results the serum 17-OHP concentration of all newborns was 0 136.8 nmol / L, with an average of (16.68 鹵6.83) nmol / L. The serum concentrations of 17-OHP were (24.23 鹵2.18), (22.34 鹵3.23), (16.56 鹵4.54), (16.10 鹵5.72) and (14.18 鹵2.56) nmol / L in newborns with gestational age 鈮，

本文編號：2100135