本文選題：兒童 + 肺炎支原體��； 參考：《中華醫(yī)院感染學(xué)雜志》2017年18期

【摘要】：目的探討肺炎支原體合并Epstein-Barr病毒感染患兒的臨床特征及免疫狀況。方法選擇2015年1月-2016年12月醫(yī)院肺炎支原體合并Epstein-Barr病毒感染患兒80例作為實(shí)驗(yàn)組,另選取肺炎支原體未合并Epstein-Barr病毒感染患兒80例作為對(duì)照組,收集兩組患兒的臨床表現(xiàn)、實(shí)驗(yàn)室檢查結(jié)果、影像學(xué)檢查結(jié)果、免疫指標(biāo)等資料。結(jié)果實(shí)驗(yàn)組患兒重癥肺炎發(fā)生率為31.25%高于對(duì)照組6.25%(P0.05),實(shí)驗(yàn)組發(fā)熱時(shí)間和住院時(shí)間分別為(13.24±3.53)d、(13.98±4.21)d顯著高于對(duì)照組(8.24±3.41)d、(9.78±4.04)d(P0.05),兩組肝腫大和淋巴結(jié)腫大發(fā)生率比較差異無(wú)統(tǒng)計(jì)學(xué)意義;實(shí)驗(yàn)組白細(xì)胞升高33.75%、AST升高36.25%、CK-MB升高42.50%均高于對(duì)照組的12.50%、11.25%、13.75%(P0.05),兩組血沉升高比例、CRP升高比例、降鈣素原升高比例比較差異無(wú)統(tǒng)計(jì)學(xué)意義;實(shí)驗(yàn)組肺實(shí)變和胸腔積液的發(fā)生率分別為21.25%、30.00%高于對(duì)照組7.50%、10.00%(P0.05),兩組肺炎類型比較差異無(wú)統(tǒng)計(jì)學(xué)意義;實(shí)驗(yàn)組CD_4~+細(xì)胞(24.31±12.14)%、CD_8~+細(xì)胞(13.76±7.98)%、CD_4~+細(xì)胞/CD_8~+細(xì)胞(1.77±0.76)、B細(xì)胞(8.96±1.87)%、NK細(xì)胞(4.24±0.78%)均低于對(duì)照組(54.64±13.64)%、(20.02±8.68)%、(2.73±1.17)、(14.78±2.13)%、(11.32±1.53)%(P0.05)。結(jié)論肺炎支原體合并Epstein-Barr病毒感染患兒病情更嚴(yán)重,肺炎支原體合并Epstein-Barr病毒感染對(duì)機(jī)體的損傷可能由免疫反應(yīng)造成。
[Abstract]:Objective to investigate the clinical features and immune status of mycoplasma pneumoniae combined with Epstein-Barr virus infection in children. Methods from January 2015 to December 2016, 80 children with mycoplasma pneumoniae combined with Epstein-Barr virus infection were selected as experimental group and 80 children without mycoplasma pneumoniae infection with Epstein-Barr virus as control group. The clinical manifestations of the two groups were collected. Laboratory examination results, imaging results, immune indicators and other data. Results the incidence of severe pneumonia in the experimental group was 31.25% higher than that in the control group (6.25%, P 0.05). The febrile time and the hospitalization time in the experimental group were 13.24 鹵3.53 d and 13.98 鹵4.21 days, respectively, which were significantly higher than those in the control group (8.24 鹵3.41). The incidence of hepatomegaly and lymphadenomegaly was not significantly different between the two groups. The increase of leukocyte and AST in the experimental group was 36.25% and the increase of CK-MB was 42.50%, which was higher than that of the control group (12.50%, 11.25%, 13.75%, P0.05%). There was no significant difference in the proportion of CRP and procalcitonin between the two groups. 瀹為獙緇勮偤瀹炲彉鍜岃兏鑵旂Н娑茬殑鍙戠敓鐜囧垎鍒負(fù)21.25%,30.00%楂樹(shù)簬瀵圭収緇，

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