本文選題：膽道閉鎖 + 肝硬化��； 參考：《青島大學(xué)》2014年碩士論文

【摘要】：目的探討CT測量肝臟體積指數(shù)(LVI)在膽道閉鎖患兒肝硬化評估中的臨床意義。方法收集2006年1月至2013年2月間在我院治療的膽道閉鎖患兒41例作為研究對象,肝纖維化程度采用Matavir分級,F0-F3為非肝硬化組,F4為肝硬化組；用64排螺旋CT測量肝臟體積(LV),并根據(jù)公式計算LVI；分析LVI與各血清學(xué)指標(biāo)的相關(guān)性,并繪制LVI的受試者工作特征曲線(receiver operating characteristic curve),簡稱ROC曲線。 結(jié)果肝硬化組和非肝硬化組LV測量值分別為148.65±28.98cm3,185.56±33.68cm3；LVI分別為0.74±0.09,0.86±0.07。肝硬化組LVI明顯低于非肝硬化組,兩組LVI差異有顯著統(tǒng)計學(xué)意義(t=-4.15,P0.05)；肝硬化組患兒年齡高于非肝硬化組,且差異有統(tǒng)計學(xué)意義(P0.05)；LVI與AST呈顯著負(fù)相關(guān)(r=-0.44,P0.05)；LVI與PLT呈顯著正相關(guān)(r=0.47,P0.05)；繪制LVI的ROC曲線,曲線下面積為0.88,選擇LVI為0.84作為診斷界點時,其敏感度為91%,特異度為83%。 結(jié)論LVI可準(zhǔn)確的反應(yīng)膽道閉鎖患兒LV變化的程度,對于評價膽道閉鎖患兒的肝硬化程度有較高準(zhǔn)確性和可靠性,可用于預(yù)測預(yù)后和提早做好肝移植準(zhǔn)備。
[Abstract]:Objective to investigate the clinical significance of hepatic volume index (LVI) measured by CT in the assessment of liver cirrhosis in children with biliary atresia. Methods 41 children with biliary atresia who were treated in our hospital from January 2006 to February 2013 were studied. The degree of hepatic fibrosis was treated with Matavir grade F0-F3 as non-cirrhosis group and F4 as cirrhosis group. The volume of liver was measured by 64-slice spiral CT, and the LVI was calculated according to the formula. The correlation between LVI and each serological index was analyzed, and the operating characteristic curve of LVI was plotted. The receiver operating characteristic curve (ROC curve) was drawn. Results the LV values of cirrhosis group and non-cirrhosis group were 148.65 鹵28.98cm3185.56 鹵33.68 cm 3 and 0.74 鹵0.09 鹵0.86 鹵0.07, respectively. The LVI of cirrhosis group was significantly lower than that of non-cirrhosis group, the difference of LVI between the two groups was statistically significant, the age of cirrhosis group was higher than that of non-cirrhosis group, the difference between the two groups was statistically significant. There was a significant negative correlation between LVI and AST. There was a significant positive correlation between LVI and PLT. The ROC curve of LVI was 0.88, and when LVI was 0.84, the sensitivity was 91 and the specificity was 833. Conclusion LVI can accurately reflect the degree of LV changes in children with biliary atresia and has high accuracy and reliability in evaluating the degree of cirrhosis in children with biliary atresia. It can be used to predict prognosis and prepare for liver transplantation.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R725.7

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本文編號：1887117