本文選題：多汗癥 + 特應性體質(zhì)/過敏體質(zhì)　； 參考：《復旦大學》2012年碩士論文

【摘要】：背景 在臨床工作中,我們發(fā)現(xiàn)以多汗為主訴就診患兒逐漸增多,且常繼發(fā)反復呼吸道感染。另外,不少過敏性疾病患兒家長抱怨孩子平時汗出過多。目前有關多汗與特應性體質(zhì)相關性的研究,國內(nèi)外多集中在成人,在兒童中開展的研究資料比較少。因此,本課題探索研究小兒多汗與特應性體質(zhì)的關系,對于指導小兒多汗癥治療,預防反復呼吸道感染具有重要意義。 目的 探討多汗與小兒特應性體質(zhì)的關系。 方法 選擇2010年8月至2012年3月復旦大學附屬上海市第五人民醫(yī)院兒科門診及病房診治患兒90例,根據(jù)臨床表現(xiàn)分為多汗組(N=45例)和非多汗組(N=45例)。通過對患兒臨床資料的分析,探討出汗與嬰兒濕疹、特應性鼻炎、過敏性結(jié)膜炎、哮喘的相關性。 結(jié)果 1.多汗組與非多汗組在性別、年齡、身高、體重、體重指數(shù)等基線資料的分布上無明顯差異(p0.05)。兩組在白細胞計數(shù)、嗜酸性粒細胞比例以及血鈣、血磷、堿性磷酸酶、免疫球蛋白E的分布上亦無明顯差異(p0.05)。 2.多汗組與非多汗組患兒在家族多汗史的分布上有顯著差異(p0.05)；兩組在家族過敏史的分布上無差異(p0.05)。 3.多汗組與非多汗組在嬰兒濕疹、變應性鼻炎及過敏性結(jié)膜炎的分布上無明顯差異(p0.05)；多汗組哮喘患病率以及過敏原陽性率均高于非多汗組(p0.05)。 結(jié)論 1.小兒常見頭頸、軀干等部位多汗。 2.多汗患兒常伴有家族多汗史。 3.哮喘、皮膚點刺試驗過敏原陽性是小兒多汗的危險因素,提示多汗可能與特應性體質(zhì)相關。 背景 支氣管哮喘是兒童常見呼吸道慢性疾病之一。隨著《全球哮喘防治創(chuàng)議》(GINA)方案在各國的推廣和實施,全球哮喘的診斷和治療得以統(tǒng)一化和規(guī)范化,哮喘的診斷和治療水平得到了明顯的提高,但哮喘,尤其是小兒哮喘的患病率仍呈不斷上升趨勢。臨床工作中,我們發(fā)現(xiàn)不少哮喘患兒家長抱怨孩子出汗多,此癥狀進一步誘發(fā)了反復呼吸道感染及哮喘發(fā)作,形成了惡性循環(huán),并對孩子的健康造成了一定的傷害。但目前國內(nèi)外針對小兒哮喘與多汗關系的研究文獻較少見,國外研究多集中在成人。因此,本課題探討哮喘患兒安靜時多汗狀況及其相關危險因素,以期進一步加強對小兒哮喘的診斷與治療。 目的 了解哮喘患兒中多汗患病率及多汗的危險因素。 方法 選擇2010年8月至2012年3月隨訪于復旦大學附屬上海市第五人民醫(yī)院兒科門診及病房診斷明確的哮喘患兒55例,根據(jù)臨床表現(xiàn)分為多汗組(N=35例)和非多汗組(N=20例)。通過對患兒臨床資料的統(tǒng)計分析,了解哮喘患兒中多汗發(fā)病率,對多汗與嬰兒濕疹、特應性鼻炎、過敏性結(jié)膜炎的關系進行分析。 結(jié)果 1.哮喘多汗組與非多汗組在性別、年齡、身高、體重、體重指數(shù)等基線資料的分布上無明顯差異(p0.05)。兩組在血鈣、血磷、堿性磷酸酶、免疫球蛋白E、嗜酸性粒細胞比例的分布上亦無明顯差異(p0.05)。 2.兩組患兒在家族多汗史及過敏史的分布上均無差異(p0.05)。 3.兩組患兒在嬰兒濕疹、結(jié)膜炎的分布上無明顯差異(p0.05)；哮喘多汗組變應性鼻炎發(fā)病率高于非多汗組(p0.05)。兩組過敏原陽性率無差異(p0.05)。 結(jié)論 1.哮喘多汗患病率為35/55,約63%。 2.變應性鼻炎是哮喘患兒多汗的危險因素。
[Abstract]:background
In clinical work, we found that children with sweating as the main complaint are gradually increasing and often secondary respiratory infection. In addition, many parents of children with allergic diseases complain about the excessive sweat in children. At present, the study on the correlation between hyperhidrosis and atopic constitution is concentrated in adults at home and abroad, and the research data in children are compared. Therefore, it is of great significance to study the relationship between children's hyperhidrosis and atopic constitution in order to guide the treatment of hyperhidrosis and prevent recurrent respiratory infection.
objective
To explore the relationship between hyperhidrosis and children's atopic constitution.
Method
From August 2010 to March 2012, 90 children were diagnosed and treated in the outpatient department of Pediatrics and ward of the Fifth People's Hospital of Shanghai, Shanghai, which were divided into the hyperhidrosis group (N=45) and the non hyperhidrosis group (N=45) according to the clinical manifestations. Through the analysis of the clinical data of the children, the perspiration was related to the infant's wet rash, atopic rhinitis, allergic conjunctivitis, and asthma. Sex.
Result
There was no significant difference in the distribution of baseline data of sex, age, height, weight and body mass index between the 1. perspiration group and the non perspiration group (P0.05). There was no significant difference in the distribution of leukocyte count, eosinophil ratio and blood calcium, blood phosphorus, alkaline phosphatase and immunoglobulin E in the two groups (P0.05).
2. there was a significant difference in the distribution of familial hyperhidrosis between hyperhidrosis group and non hyperhidrosis group (P0.05), and there was no difference in the family history of allergy between the two groups (P0.05).
There was no significant difference in the distribution of eczema, allergic rhinitis and allergic conjunctivitis between the 3. perspiration group and the non perspiration group (P0.05). The prevalence of asthma and the positive rate of allergen were higher in the hyperhidrosis group than in the non hyperhidrosis group (P0.05).
conclusion
1. the common head and neck of children, the trunk and other parts are sweaty.
2. Chang Banyou family, the history of perspiration in the family of children with perspiration.
3. asthma, skin prick test, allergen positive is a risk factor for hyperhidrosis in children, suggesting that hyperhidrosis may be related to atopic constitution.
background
Bronchial asthma is one of the common chronic respiratory diseases in children. With the promotion and implementation of the global proposal for asthma prevention and treatment (GINA) in various countries, the diagnosis and treatment of asthma in the world are unified and standardized, the diagnosis and treatment of asthma have been significantly improved, but the prevalence of asthma, especially in children's asthma, is still continuing. In clinical work, we have found that many parents of children with asthma complain that children are sweating more, which further induce recurrent respiratory infection and asthma attacks, forming a vicious cycle and causing certain harm to the health of children. However, the research literature on the relationship between children's asthma and hyperhidrosis is rare at home and abroad. Therefore, the subject is to explore the perspiration and related risk factors of children with asthma in silence in order to further strengthen the diagnosis and treatment of children with asthma.
objective
Objective to understand the prevalence of sweating and risk factors for sweating in asthmatic children.
Method
From August 2010 to March 2012, 55 cases of asthma in the outpatient department of Pediatrics and ward of the Fifth People's Hospital of Shanghai, Shanghai, affiliated to Fudan University, were selected. According to the clinical manifestations, the patients were divided into the hyperhidrosis group (N=35) and the non sweaty group (N=20). The incidence of hyperhidrosis in the children with asthma was analyzed by the statistical analysis of the clinical data of the children. The relationship between infantile eczema, atopic rhinitis and allergic conjunctivitis was analyzed.
Result
There was no significant difference in the distribution of baseline data on sex, age, height, weight and body mass index (P0.05). There was no significant difference in the distribution of blood calcium, blood phosphorus, alkaline phosphatase, immunoglobulin E and eosinophil (P0.05) in the two groups of asthma and hyperhidrosis (P0.05).
2. there was no difference in the distribution of family history of sweating and allergy between the two groups (P0.05).
There was no significant difference in the distribution of conjunctivitis between the 3. children and the two groups (P0.05), and the incidence of allergic rhinitis in the hyperhidrosis group was higher than that in the non perspiration group (P0.05). There was no difference in the positive rate of allergens in the two groups (P0.05).
conclusion
1. the prevalence of hyperhidrosis in asthma was 35/55, about 63%.
2. allergic rhinitis is a risk factor for hyperhidrosis in asthmatic children.

【學位授予單位】：復旦大學
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：R725.6

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本文編號：1823995