本文選題：過敏性紫癜腎炎 + 中性粒/淋巴細胞比值�。� 參考：《山西醫(yī)科大學(xué)》2012年碩士論文

【摘要】：目的：近些年來在不同年齡層的兒童人群中過敏性紫癜的發(fā)病率持續(xù)增高。過敏性紫癜從病理上約100%有腎臟損傷，但有腎損臨床表現(xiàn)者約30-50%。影響過敏性紫癜患兒預(yù)后的第一要素是腎臟的損害程度。因此從臨床角度構(gòu)建針對過敏性紫癜腎臟損傷趨勢的早期預(yù)警思路和方法，對指導(dǎo)治療和確定患兒預(yù)后將具有重要意義，至目前國內(nèi)外相關(guān)研究報道還比較少。本研究的目的在于探討過敏性紫癜患兒外周血中性粒細胞與淋巴細胞的比值、嗜酸粒細胞及血小板參數(shù)對過敏性紫癜腎炎發(fā)生的預(yù)測價值，提高對可能發(fā)生不良并發(fā)癥患兒的檢出率，，以便醫(yī)務(wù)人員采取積極措施，降低患兒紫癜性腎炎的發(fā)生率。 方法：對2010年9月——2011年9月山西醫(yī)科大學(xué)附屬第一臨床醫(yī)院收住院的100例處于過敏性紫癜急性期患兒，入院時在未給予任何治療前抽血檢測其血清中性粒細胞，淋巴細胞，嗜酸粒細胞絕對值，血小板各參數(shù)，并計算中性粒細胞與淋巴細胞比值。將100例病例按不同性別分為男生組（57例）和女生組（43例）；按入院時是否存在上呼吸道感染感染分為感染者組（39例）和非感染者組（61例）；按入院時是否出現(xiàn)腎臟損害的表現(xiàn)分為腎臟損害組（35例）和腎臟無損害組（65例）。 結(jié)果：過敏性紫癜腎炎組中性粒細胞與淋巴細胞的比值（2.38±0.13）高于無腎損害組（1.80±0.15）,紫癜腎炎組嗜酸粒細胞（0.35±0.66）較無腎損害組（0.07±0.07）明顯升高，差異有統(tǒng)計學(xué)意義（P0.01）。過敏性紫癜腎炎組血小板參數(shù)（PLT、MPV、PDW）與無腎損害組比較，差異有統(tǒng)計學(xué)意義（P0.05）。結(jié)論：HSPN患兒外周血NLR和Eo、PLT、MPV、PDW水平顯著升高，可以作為一種簡便的診斷HSPN的標記物，尤其是對疾病早期的篩查可能具有更好的價值。
[Abstract]:Objective: the incidence of Henoch-Schonlein purpura in children of different ages has been increasing in recent years. About 100% of Henoch-Schonlein purpura had renal injury pathologically, but 30-50% had renal lesion. The first factor affecting the prognosis of children with Henoch-Schonlein purpura is the degree of renal damage. Therefore, it is important to construct an early warning method for the trend of renal injury in Henoch-Schonlein purpura from the clinical point of view, which will be of great significance in guiding the treatment and determining the prognosis of children. The purpose of this study was to investigate the predictive value of the ratio of peripheral blood neutrophils to lymphocytes, eosinophils and platelet parameters in the occurrence of Henoch-Schonlein purpura nephritis in children with Henoch-Schonlein purpura. In order to reduce the incidence of Henoch-Schonlein purpura nephritis (HSPN), medical staff should take active measures to improve the detection rate of children with possible adverse complications. Methods: from September 2010 to September 2011, 100 children in the acute phase of Henoch-Schonlein purpura were collected from the first affiliated Clinical Hospital of Shanxi Medical University, and their serum neutrophils and lymphocytes were detected before receiving any treatment. The absolute value of eosinophils, platelet parameters and the ratio of neutrophils to lymphocytes were calculated. 100 cases were divided into male group (57 cases) and female group (43 cases) according to sex. According to the presence of upper respiratory tract infection at admission, 39 cases were divided into infected group (n = 39) and non-infected group (n = 61). There were 35 cases of renal injury group and 65 cases of no renal injury group. Results: the ratio of neutrophil to lymphocyte in Henoch-Schonlein purpura nephritis group (2.38 鹵0.13) was higher than that in no renal lesion group (1.80 鹵0.15), and the eosinophils in purpura nephritis group (0.35 鹵0.66) was significantly higher than that in no renal lesion group (0.07 鹵0.07). The platelet parameters of patients with Henoch-Schonlein purpura nephritis were compared with those without renal lesion (P 0.05). Conclusion the levels of NLR and EOPLT in peripheral blood of children with HSPN were significantly increased, which could be used as a simple marker for the diagnosis of HSPN, especially in the early screening of the disease.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R726.9

【參考文獻】

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1 曾雪琪;許自川;黨西強;何小解;易著文;;血管內(nèi)皮生長因子與紫癜性腎炎腎間質(zhì)微血管損傷的關(guān)系[J];中國當(dāng)代兒科雜志;2009年09期

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