本文選題：病原菌　切入點：藥敏分析　出處：《實用醫(yī)學(xué)雜志》2017年17期 　論文類型：期刊論文

【摘要】：目的分析住院新生兒臨床分離病原菌的分布特點及藥敏結(jié)果,為臨床合理選擇抗菌素提供參考。方法以新生兒臨床標(biāo)本中分離出病原菌為研究對象,分析病原菌的分布及耐藥特點。15 796份標(biāo)本按操作規(guī)范培養(yǎng)分離,經(jīng)全自動細菌鑒定系統(tǒng)VITEK-2 compact進行鑒定及藥敏試驗,應(yīng)用WHONET5.4軟件分析藥敏結(jié)果。結(jié)果共分離病原菌1 125株,陽性率為7.1%,G-菌742株,占66.0%;G+菌355株,占31.6%,肺炎克雷伯菌和金黃色葡萄球菌分別占G-菌和G+菌的首位。G-菌對氨芐西林、一/二代頭孢等耐藥率較高,肺炎克雷伯菌、銅綠假單胞菌和鮑曼不動桿菌對亞胺培南的抵抗率24.0%。葡萄球菌中的MRSA和MRSCN的檢出率分別是35.7%、73.3%,對青霉素、頭孢類、紅霉素等不同程度耐藥,對萬古霉素、替加環(huán)素等100%敏感。結(jié)論住院新生兒臨床分離的病原菌以G-桿菌和葡萄球菌為主,耐藥性較為嚴(yán)重。
[Abstract]:Objective to analyze the distribution characteristics and drug sensitivity of pathogenic bacteria in clinical isolation of hospitalized neonates, and to provide a reference for the rational selection of antibiotics. Methods the pathogenic bacteria isolated from clinical specimens of newborns were taken as the research objects. The distribution and drug resistance characteristics of pathogenic bacteria were analyzed. 15 796 samples were cultured according to the standard of operation. The results of identification and susceptibility tests were carried out by automatic bacterial identification system VITEK-2 compact, and the results of drug sensitivity were analyzed by WHONET5.4 software. Results 1 125 strains of pathogenic bacteria were isolated. The positive rate was 7.42 strains of G- bacteria, which accounted for 66.0G, and occupied 31.660.The resistance rates of Klebsiella pneumoniae and Staphylococcus aureus to ampicillin and cephalosporin were higher than those of Staphylococcus aureus and Klebsiella pneumoniae, respectively, and the resistance rate of Klebsiella pneumoniae to ampicillin and the first / second generation of cephalosporins was higher than that of Staphylococcus aureus. The resistance rate of Pseudomonas aeruginosa and Acinetobacter baumannii to imipenem was 24.0.The detectable rate of MRSA and MRSCN in Staphylococcus was 35.73.3cm, resistant to penicillin, cephalosporins, erythromycin and vancomycin, respectively. Conclusion the main pathogens isolated from hospitalized neonates are G- bacilli and Staphylococcus, and the drug resistance is more serious.
【作者單位】： 廣東省婦幼保健院醫(yī)院感染管理科;
【基金】：廣東省醫(yī)學(xué)科學(xué)技術(shù)研究基金項目(編號:B2015136)
【分類號】：R446.5;R722.1

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