發(fā)布時間：2018-03-18 07:02

  本文選題：全面性發(fā)育遲緩　切入點：生酮飲食　出處：《中國當(dāng)代兒科雜志》2017年10期 　論文類型：期刊論文

【摘要】：目的觀察生酮飲食(KD)對全面性發(fā)育遲緩(GDD)患兒神經(jīng)行為發(fā)育、情緒和社會行為及生活能力的影響。方法采用前瞻性病例對照研究,對住院的GDD患兒隨機分為KD治療組和常規(guī)治療組,最終常規(guī)治療組37例和KD治療組40例納入研究。兩組患兒均進行綜合康復(fù)訓(xùn)練,KD治療組在此基礎(chǔ)上給予生酮飲食改良Atkins治療方案。治療前及治療后3、6、9個月對兩組患兒進行Gesell發(fā)育量表、中國幼兒情緒性及社會性發(fā)展量表(CITSEA)/Achenbach兒童行為量表(CBCL)、嬰兒-初中學(xué)生社會生活能力量表(S-M量表)評估,比較2組之間神經(jīng)行為發(fā)育、情緒和社會行為及生活能力的改善情況。結(jié)果治療后3、6、9個月兩組患兒Gesell評分比較,在適應(yīng)性、精細動作、言語3個能區(qū)的評分,KD治療組改善情況優(yōu)于常規(guī)治療組(P0.05);治療后3、6、9個月兩組患兒CITSEA/CBCL評分比較,KD治療組改善情況亦優(yōu)于常規(guī)治療組(P0.05);治療后9個月KD治療組S-M量表評分改善情況優(yōu)于常規(guī)治療組(P0.05)。KD治療期間,6例患兒出現(xiàn)腹瀉癥狀,1例出現(xiàn)輕度泌尿系結(jié)石。結(jié)論 KD治療可改善GDD患兒的神經(jīng)行為發(fā)育及情緒和社會行為,且不良反應(yīng)少。
[Abstract]:Objective to observe the effect of ketone diet on neurobehavioral development, emotion, social behavior and life ability in children with GDDs. Methods A prospective case-control study was conducted. The hospitalized children with GDD were randomly divided into KD treatment group and routine treatment group. In the end, 37 cases of routine treatment group and 40 cases of KD treatment group were included in the study. All children in both groups received comprehensive rehabilitation training. On this basis, the KD treatment group was given a modified Atkins regimen of ketogenic diet. Before and after treatment, 69 months were given to both groups. Gesell development scale was used in children. Chinese Young Children's emotional and Social Development scale CITSEAA / Achenbach Child behavior scale (CBCLA) and Infant Junior Middle School students' Social Life ability scale (S-M) were used to compare the neurobehavioral development between the two groups. Results the Gesell scores of the two groups were compared in adaptability, fine motion, and fine movement after treatment for 6 months and 9 months after treatment. The improvement of KD treatment group was better than that of routine treatment group, the CITSEA/CBCL score of KD treatment group was better than that of routine treatment group, and the improvement of KD treatment group was better than that of routine treatment group at 9 months after treatment, and 9 months after treatment, the improvement of KD treatment group was better than that of routine treatment group, and 9 months after treatment, the improvement of KD treatment group was better than that of routine treatment group. The improvement of score was better than that of routine treatment group (P 0.05). KD could improve the neurobehavioral development, emotion and social behavior of children with GDD. And the adverse reaction was less.
【作者單位】： 鄭州大學(xué)第三附屬醫(yī)院兒童康復(fù)科/河南省小兒腦損傷重點實驗室/鄭州市兒童腦癱防治重點實驗室;
【分類號】：R749.94

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