本文選題：新生兒重癥監(jiān)護(hù)室　切入點(diǎn)：早產(chǎn)兒　出處：《浙江大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：研究目的:對(duì)新生兒重癥監(jiān)護(hù)室(Neonatal Intensive Care Unit,NICU)早產(chǎn)兒醫(yī)院感染相關(guān)危險(xiǎn)因素進(jìn)行Meta分析,為NICU早產(chǎn)兒醫(yī)院感染的預(yù)防控制提供理論支持和指導(dǎo)意見(jiàn)。研究方法:在線檢索中外文數(shù)據(jù)庫(kù)Cochrane library、PubMed、中國(guó)生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(kù)(CBM)、萬(wàn)方數(shù)據(jù)庫(kù)、維普數(shù)據(jù)庫(kù)、中國(guó)知網(wǎng)(CNKI),采用順查法、倒查法、文獻(xiàn)追溯的方法盡可能獲得相關(guān)的參考文獻(xiàn),全面搜集國(guó)內(nèi)外有關(guān)于NICU早產(chǎn)兒發(fā)生醫(yī)院感染相關(guān)危險(xiǎn)因素的原始文獻(xiàn),采用主題詞、自由詞相結(jié)合的檢索策略進(jìn)行檢索,檢索語(yǔ)種僅限于中文和英文。篩選出符合評(píng)價(jià)標(biāo)準(zhǔn)的文獻(xiàn),使用Review Manager 5.3軟件對(duì)納入的文獻(xiàn)進(jìn)行Meta分析,對(duì)計(jì)算結(jié)果采用固定效應(yīng)模型和隨機(jī)效應(yīng)模型做敏感性分析,異質(zhì)性較大的研究運(yùn)用STATA軟件對(duì)相關(guān)危險(xiǎn)因素逐一進(jìn)行Meta回歸分析。研究結(jié)果:本研究共納入8項(xiàng)研究,6個(gè)相關(guān)因素進(jìn)行Meta分析,評(píng)估相關(guān)危險(xiǎn)因素比值比及95%可信區(qū)間,分別為:體質(zhì)量≤2500g OR=2.71,95%CI1.59～4.59;機(jī)械通氣 OR=2.66,95%CI1.39～5.11;中心靜脈留置 OR=6.91,95%CI3.87～12.35;全胃腸外營(yíng)養(yǎng) OR=2.45,95%CI 1.06～5.68;胃管留置 OR=3.22,95%CI(1.08～9.61);預(yù)防用抗菌藥物OR=2.57,95%CI(0.84～7.80)無(wú)明顯統(tǒng)計(jì)學(xué)意義,其他各研究間差異存在統(tǒng)計(jì)學(xué)意義。Meta回歸分析結(jié)果分析顯示最終納入回歸中的變量是地域,提示地域可能解釋一部分異質(zhì)性原因。結(jié)論:Meta分析表明低體質(zhì)量、機(jī)械通氣、胃管留置、全胃腸外營(yíng)養(yǎng)、中心靜脈留置使NICU早產(chǎn)兒更易發(fā)生醫(yī)院感染。預(yù)防用抗菌藥物不是早產(chǎn)兒NI的危險(xiǎn)因素。
[Abstract]:Objective: to analyze the risk factors of nosocomial infection in Neonatal Intensive Care unit by Meta. To provide theoretical support and guidance for the prevention and control of nosocomial infection in premature infants of NICU. Methods: online retrieval of Chinese and foreign language database Cochrane librarybrium PubMed, Chinese biomedical literature database (CBM), Wanfang database, Weip database, etc. CNKI, with the methods of sequential, backward and retrospective, obtained as many references as possible, collected all the original literature at home and abroad on the risk factors of nosocomial infection in premature infants with NICU, and adopted the theme words. The retrieval strategy combined with free words is only limited to Chinese and English. The literature that meets the evaluation criteria is screened. The Meta analysis of the included documents is carried out by using Review Manager 5.3 software. The fixed effect model and the random effect model are used to analyze the sensitivity of the calculation results. STATA software was used to analyze the risk factors one by one by Meta regression analysis. Results: this study included 8 studies, 6 related factors were analyzed by Meta, the ratio of related risk factors and the 95% confidence interval were evaluated. They were: body weight 鈮，

本文編號(hào)：1622737