發(fā)布時間：2018-03-01 11:20

  本文關鍵詞： 先天性心臟病(CHD) CYP基因多態(tài)性 環(huán)境危險因素暴露 交互作用　出處：《中國公共衛(wèi)生》2017年09期 　論文類型：期刊論文

【摘要】：目的探討子代CYP450基因多態(tài)性及母親孕期環(huán)境危險因素暴露與先天性心臟病(CHD)發(fā)病的關系以及二者在CHD發(fā)生中是否存在交互作用。方法采用病例對照研究方法,將2011年10月-2013年1月在山東省濟寧醫(yī)學院第一附屬醫(yī)院確診的160例0~7周歲單純性CHD患兒和同期在該院進行體檢或就診的160例非心臟病幼兒分別作為病例組和對照組,采用訪談方式進行問卷調查,獲得研究對象母親孕期環(huán)境危險因素暴露信息,采集研究對象空腹靜脈,血應用聚合酶鏈反應-限制性片段長度多態(tài)性分析法(PCR-RFLP)檢測CYP450基因多態(tài)性;應用單因素和多因素條件logistic回歸模型分析子代CYP450基因多態(tài)性和母親孕期環(huán)境危險因素暴露與CHD發(fā)病的關聯強度,并采用相加模型交互作用指標評價二者的交互作用。結果多因素條件logistic回歸分析結果顯示,子代CYP1A1基因rs1048943位點純合子突變型是CHD發(fā)病的保護因素(OR=0.369,95%CI=0.138~0.986);母親孕前3個月使用染發(fā)劑(OR=5.621.95%CI=1.401~22.541)、孕前3個月被動吸煙(OR=2.511,95%CI=1.342~4.699)、孕早期被動吸煙(OR=2.441,95%CI=1.306~4.561)、孕早期居住在3年內裝修過的居室(OR=4.159,95%CI=1.698~10.182)和孕早期服用解熱鎮(zhèn)痛藥(OR=3.901,95%CI=1.271~11.971)是CHD發(fā)病的危險因素。交互作用分析結果顯示,子代攜帶CYPIA1 rs1048943位點純合子突變型有減弱環(huán)境因素致病風險的趨勢,但交互作用指標無統計學意義。結論子代攜帶CYP1A1純合子突變型對CHD發(fā)病有保護作用,母親孕前及孕早期應盡量避免或減少環(huán)境危險因素的暴露,以預防子代CHD的發(fā)生。
[Abstract]:Objective to investigate the relationship between maternal exposure to maternal environmental risk factors and the incidence of congenital heart disease (CHD) and whether there is interaction between the polymorphism of CYP450 gene and maternal risk factors in the development of congenital heart disease. Methods Case-control study was used to study the relationship between the polymorphisms of CYP450 gene and the incidence of congenital heart disease. From October 2011 to January 2013, 160 children with simple CHD aged 0 to 7 years old diagnosed in the first affiliated Hospital of Jining Medical College of Shandong Province and 160 children with non-heart disease who were examined or visited in the same period were taken as the case group and the control group, respectively. Questionnaire survey was conducted to obtain the exposure information of maternal environmental risk factors during pregnancy, and the fasting veins of the subjects were collected. CYP450 gene polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP). Univariate and multivariate conditional logistic regression models were used to analyze the association between maternal exposure to maternal environmental risk factors and CYP450 gene polymorphisms. The interaction index of additive model was used to evaluate the interaction between the two. Results the results of multivariate conditional logistic regression analysis showed that, The homozygous mutation at rs1048943 locus of CYP1A1 gene in offspring is the protective factor of CHD. The mother uses hair dye OR5.621.95CII 1.401a 22.541 in 3 months before pregnancy, OR2.51195CI1.3424.699 in the first trimester of pregnancy, 2.44195CII 1.3066.561in the first trimester of pregnancy and 1.3066.561in the first trimester of pregnancy. The risk factors of CHD were 4.159 ~ 95% CIQ 1.698 + 10.182) and the antipyretic analgesics 3.901 ~ 95% ~ 1.271 ~ 11.971) in early pregnancy, and the results of interaction analysis showed that, The homozygous mutation of CYPIA1 rs1048943 locus in progeny had the tendency to reduce the risk of environmental factors, but there was no statistical significance in the index of interaction. Conclusion the homozygote mutation of CYP1A1 in offspring has protective effect on the pathogenesis of CHD. Mothers should avoid or reduce exposure to environmental risk factors before pregnancy and early pregnancy in order to prevent the occurrence of CHD in their offspring.
【作者單位】： 復旦大學公共衛(wèi)生學院;上海市計劃生育科學研究所;濟寧醫(yī)學院公共衛(wèi)生學院;天津醫(yī)科大學公共衛(wèi)生學院;
【基金】：上海市出生缺陷重點實驗室2015年開放課題(15DZKF1009)
【分類號】：R725.4

【相似文獻】

相關期刊論文 前10條

1 金敏;楊彥春;;兒童青少年行為問題的遺傳及環(huán)境危險因素[J];華西醫(yī)學;2007年03期

2 任宏,歐陽鳳秀,羅飛宏,沈水仙,姜慶五;兒童1型糖尿病環(huán)境危險因素病例對照研究[J];中國公共衛(wèi)生;2005年02期

3 沈麗琴;陳希寧;李昌吉;李朝英;洪源;;兒童單純性肥胖癥的遺傳和環(huán)境危險因素分析[J];中國學校衛(wèi)生;2006年09期

4 李正直;丁文清;鄭漪;左鋒;;寧夏兒童三種血液疾病環(huán)境危險因素病例-對照研究[J];寧夏醫(yī)學院學報;2007年03期

5 高莉潔,趙仲堂,李棟,姜寶法,郝鳳榮,馮月秋;先天性心臟病環(huán)境危險因素病例對照研究[J];中國公共衛(wèi)生;2005年02期

6 陳金清;黃國忠;趙金樹;謝金標;陳豪;鮑德勝;;76例新生兒先天性心臟病環(huán)境危險因素對照研究[J];福建醫(yī)藥雜志;2011年03期

7 鄭杰洪;劉小清;;先天性心臟病的遺傳和環(huán)境危險因素新認識[J];嶺南心血管病雜志;2008年06期

8 Morgan W.J.,Crain E.F. ,Gruchalla R.S. ,劉健;居室環(huán)境干預對都市哮喘病患兒的影響[J];世界核心醫(yī)學期刊文摘(兒科學分冊);2005年02期

9 袁雪;王惠珊;閆淑娟;王曉華;朱雪娜;盧秀英;;10665名兒童先天性心臟病發(fā)病狀況監(jiān)測結果和環(huán)境危險因素分析[J];中國婦幼保健;2006年06期

10 劉淮玉;吳建華;徐慧華;袁東;;少年兒童哮喘與居家裝修環(huán)境危險因素分析[J];環(huán)境與職業(yè)醫(yī)學;2010年08期

相關會議論文 前2條

1 侯佳;桂永浩;奚立;張俊;儲晨;高珊;;先天性心臟病環(huán)境危險因素的病例對照研究[A];2006（第三屆）江浙滬兒科學術會議暨浙江省兒科學術年會論文匯編[C];2006年

2 侯佳;桂永浩;奚立;張俊;儲晨;高珊;;先天性心臟病環(huán)境危險因素的病例對照研究[A];中華醫(yī)學會第十四次全國兒科學術會議論文匯編[C];2006年

相關碩士學位論文 前1條

1 寇麗茹;沈陽市兒童1型糖尿病環(huán)境危險因素的病例對照研究[D];中國醫(yī)科大學;2007年

，

本文編號：1551702