本文關(guān)鍵詞： 手足口病 再次罹患 隊列研究 流行病學　出處：《福建醫(yī)科大學》2015年碩士論文　論文類型：學位論文

【摘要】：目的探討福建省4歲兒童手足口病再次罹患特征,為制定防控策略提供依據(jù)。方法運用隊列研究方法以福建省手足口病監(jiān)測資料中4歲患兒為研究對象,以首次罹患時的特征作為其再次罹患的影響因素,采用SAS 9.0軟件的logistic逐步回歸法篩選。結(jié)果共納入研究對象82 949例,其中多次罹患者2 612例(3.15%)。在多次罹患者中,累計罹患2次者2 510例,3次者98例,4次者3例,5次者1例。年齡2歲和2歲者首次罹患時,其再次罹患風險分別是年齡為3歲者的4.39(95%CI:3.80~5.07)倍和2.73(95%CI:2.35~3.18)倍;以居住地區(qū)6歲兒童手足口病患病率2%為對照,患病率4%、3%~4%和2%~3%的再次罹患風險分別為2.15(95%CI:1.88~2.45)倍、2.10(95%CI:1.85~2.38)倍和1.65(95%CI:1.44~1.89)倍;在婦幼保健機構(gòu)就診者再次罹患風險是在非婦幼保健機構(gòu)就診者的1.64(95%CI:1.51~1.78)倍;男性再次罹患風險是女性的1.34(95%CI:1.23~1.46)倍。引起再次罹患的主要病原是腸道病毒(EV)71型(33/60),再次罹患可進展為重癥病例(8/2612);首次、再次罹患的致病病原有可能均為EV71型毒株(3/6)。結(jié)論是否重復(fù)罹患與其再次接觸病原體的機會密切相關(guān),對首次罹患的低齡幼兒應(yīng)及時采取干預(yù)措施。
[Abstract]:Objective to investigate the reattack characteristics of HFMD in 4-year-old children in Fujian Province, and to provide evidence for the formulation of prevention and control strategies. Methods A cohort study was carried out on 4-year-old children with HFMD surveillance data in Fujian Province. The characteristics of the first attack were used as the influencing factors, and the logistic stepwise regression method of SAS 9.0 software was used to screen the patients. Results A total of 82 949 subjects were included in the study, 2 612 of whom suffered from multiple attacks (3.15%). There were 2 510 cases with 2 510 cases and 3 cases with 3 times and 3 cases with 4 times and 1 case with 5 times. At the first attack of 2 years old and 2 years old, the risk of the second attack was 4.3995 CI: 3.805.07 and 2.73 95% CI2.353.18, respectively. The prevalence rate of HFMD in children aged 6 years in the residential area was 2%. The risk of reattack was 2.15% and 2%, respectively, 2.1095% and 1.65% respectively. The risk of reattack in MCH was 1.6495 CI 1.51% and 1.65 95% 1.51% respectively, and the risk was 1.6495 CI 1.51% 1.78 times higher than that in non-MCH institutions. The risk of reinfection in men is 1.3495 CI: 1.231.46). The main cause of resuscitation is the enterovirus EVS71 (33 / 60%), which can progress to 8 / 2612% of severe cases again; for the first time, Conclusion it is closely related to the chance of repeated exposure to the pathogen, and the intervention should be taken in time for the young children who first suffer from the disease.
【學位授予單位】：福建醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：R725.1

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本文編號：1515030