針灸是古代中國的醫(yī)療精粹,用于治療各種疾病和癥狀長達2000多年。針灸目前已經(jīng)在全世界范圍內(nèi)廣泛流行,許多對傳統(tǒng)療法耐受的疾病,運用針灸進行治療,取得了顯著效果。同時針灸克服了藥物療法的副作用。針灸吸引了大量的基礎(chǔ)研究者觀察其對人和動物的鎮(zhèn)痛效果,并研究這種神奇療效背后的機制。針灸為治療疼痛提供了一種顯著又安全的方法,這使得針灸在獸醫(yī)中快速發(fā)展。美國動物醫(yī)院協(xié)會和美國貓科動物從業(yè)者協(xié)會聯(lián)合發(fā)布了犬貓?zhí)弁垂芾淼臈l例,該條例指出,越來越多有力的證據(jù)表明針灸療法已成為獸醫(yī)普遍接受的治療疼痛性疾病的方式。1.電針結(jié)合肌肉注射右旋美托咪啶鎮(zhèn)痛對山羊生理生化的影響。試驗目的：研究電針結(jié)合右旋美托咪啶對山羊鎮(zhèn)痛效果及對生理生化的影響。試驗動物：30只雜交健康雌性山羊。試驗方法：山羊隨機分成5組：電針組,兩種劑量的右旋美托咪啶(5和20μg/kg, IM),電針加右旋美托咪啶(5μg/kg,IM)和對照組(0.9%NaCl,IM)。檢測痛閾、心肺功能、直腸溫度和血液及生化指標。試驗結(jié)果：右旋美托咪啶(20μ/kg)可以提高山羊痛閾、降低心律、呼吸頻率和指腸溫度。與電針組30min后和右旋美托咪啶組(5...

【文章頁數(shù)】：103 頁

【學位級別】：博士

【文章目錄】：
摘要
Abstract
Abbreviations
Chapter 1.Introduction
    1.1 Acupuncture Analgesia
    1.2 Alpha2 agonists and its application in Small Ruminants
        1.2.1 Alpha2 adrenoceptor subtypes and their agonists
        1.2.2 Uses of alpha2 adrenergic agonists
            1.2.2.1 Sedative effects
            1.2.2.2 Analgesic effects
            1.2.2.3 Anesthetic sparing effects
        1.2.3 Side effects of alpha2 agonists
            1.2.3.1 Cardiovascular effects
            1.2.3.2 Respiratory effects
            1.2.3.3 Other side effects of alpha2 agonists
        1.2.4 Antagonism
    1.3 Acupuncture-drug balanced analgesia
    1.4 The mitogen-activated protein kinases
        1.4.1 Extracellular signal regulated kinases
        1.4.2 Phosphorylation of Extracellular signal regulated kinases
        1.4.3 ERK and pain
            1.4.3.1 Activation of ERKs in primary afferent neurons
            1.4.3.2 Activation of ERKs in spinal cord neurons
            1.4.3.3 Activation of ERKs in the brain
    1.5 Objectives of the proposed research
        1.5.1 Objective-1:(program-1)
        1.5.2 Objectives-2:(program-2)
Chapter 2.Physiological and biochemical effects of electroacupuncture combined withintramuscular administration of dexmedetomidine to provide analgesia in goats
    2.1 Materials and methods
        2.1.1 Animal preparation
        2.1.2 Experimental design
        2.1.3 Electroacupuncture
        2.1.4 Physiologic variables
        2.1.5 Hematological and biochemical parameters
        2.1.6 Statistical analysis
    2.2 Results
        2.2.1 Sedative and analgesic effects
        2.2.2 Cardiorespiratory functions and rectal temperatures
        2.2.3 Biochemical and hematological parameters
    2.3 Discussion
Chapter 3.Effect of Electroacupuncture on Activation of ERK1/2-IR cells in the CentralNervous System of Rats with Inflammatory Pain
    3.1 Material and Method
        3.1.1 Animals and grouping
        3.1.2 Eletroacupuncture treatment
        3.1.3 Measurement of paw volume
        3.1.4 Paw withdrawal thresholds
        3.1.5 Immunohistochemistry
        3.1.6 Statistical analysis
    3.2 Results
        3.2.1 Effects of EA on CFA induced Paw Edema in Rats
        3.2.2 Effects of EA on CFA induced PWTs in Rats
        3.2.3 Effect of EA on Phosphor-pERK1/2-Immunoreactivity(pERK1/2-IR) Expression in the Spinal Dorsal Horn in CFA Rats
        3.2.4 Effect of EA on Phosphor-pERK1/2-Immunoreactivity(pERK1/2-IR) Expression in the NRM and GiA Nuclei or area in CFA Rats
        3.2.5 Effect of EA on Phosphor-pERK1/2-Immunoreactivity(pERK1/2-IR) Expression in the Gi nucleus or area in CFA Rats
    3.3 Discussion
4 Conclusions
References
Immunohistochemistry Pictures
Acknowledgements
Dedications
Appendix



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