發(fā)布時間：2017-02-11 14:29

  本文關(guān)鍵詞：應(yīng)用PCR技術(shù)檢測獸醫(yī)生物制品中污染病毒的研究，由筆耕文化傳播整理發(fā)布。

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預(yù)防醫(yī)學(xué)與衛(wèi)生學(xué)

感染性疾病及傳染病

計算機(jī)軟件及計算機(jī)應(yīng)用

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生物制品     

  

     TSN group: 1 mL/(kg·d) TSN-ⅡA (China Pharmacy Biological Products Examination Institute, batch number: S02001300, 1 kg/bag) was injected into rats in TSN group at the beginning of the 8th week for 10 successive weeks, and all rats were killed in the 18th week.

     丹參酮組:從飼養(yǎng)至第8周開始,丹參酮ⅡA(中國藥品生物制品檢定所,批號S02001300,1kg/包)以1mL/(kg·d)劑量腹腔注射,持續(xù)用藥10周,第18周處死;

短句來源

     The rINFα1contents of 2 lots of samples (manufactured by Shanghal Institute of Biological Products) detected by the method were 19. 5 and 21.9μg/dose, respectively.

     應(yīng)用此方法測定上海生物制品研究所生產(chǎn)的rHuIFNα1（20μg／支）兩批含量分別為19．5μg／支及21.9μg／支。

短句來源

     Results:The purity of the resultant product was higher than 98.2%,the total yield approximately 65%,and contaminated endotoxin below than 2 EU·(106IU)-1·ml-1.Conclusion:An effective and suitable protocol has been established for the preparation of rh-TNFαD3a,and three batches of rh-TNFαD3a have been passed the inspection of National Institute for the Control of Pharmaceutical and Biological Products.

     結(jié)果：純度＞98．2％，回收率約為65％，內(nèi)毒素＜2Eu·（106IU）－1·ml－1。 結(jié)論：建立了適宜的rh－TNFαD3a純化方法，連續(xù)三批原料和制劑通過國家衛(wèi)生部藥品生物制品檢定所檢定，符合WHO有關(guān)基因工程產(chǎn)品臨床用藥標(biāo)準(zhǔn)，為過渡到臨床驗證打下了基礎(chǔ)。

短句來源

     At present, the cell strain used in Changchun Institute of Biological Products was constructed in the late 1980's, the yield of which is 1-2 mg HBsAg/48 hr/L and the products demanded exceed supplied.

     長春生物制品所目前生產(chǎn)所用細(xì)胞株構(gòu)建于二十世紀(jì)八十年代末，產(chǎn)量在1~2 mg HBsAg/48 hr/L，產(chǎn)品供不應(yīng)求。

短句來源

     Resveratrol group: Rats were injected with 5, 15 and 45 resveratrol mg/kg provided by Hunan Huaguang Biological Products Company Limited (batch number: 20050221, purity ≥99%) and ligated after 10 minutes.

     白藜蘆醇組:按5,15,45mg/kg劑量靜脈注射白藜蘆醇(購自湖南華光生物制品有限公司,生產(chǎn)批號:20050221,純度≥99%)10min后結(jié)扎。

短句來源

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     ②Hippocampus neuronal morphology and cell activity: After seven-day culture, the differentiated cells were divided randomly into 3 groups: Rg1 pretreatment group: After pretreated with Rg1 (1, 2, 4, 8 and 16 μmol/L, provided by China Materia Medica Biological Product Inspection Institute, batch code: 0703-200221) for 24 hours, the cells were incubated in 40 μmol/L Aβ25-35, totally for 24 hours.

     ②海馬神經(jīng)元形態(tài)及細(xì)胞活力觀察:細(xì)胞培養(yǎng)7d至分化成熟狀態(tài),然后被隨機(jī)分為3組:人參皂苷Rg1預(yù)處理組(分為1,2,4,8,16μmol/L5個濃度組),首先每加入各濃度的Rg1(中國藥品生物制品檢定所提供,批號:0703-200221)預(yù)作用24h后,再加入40μmol/L淀粉樣β蛋白25～35共孵育24h;

短句來源

     The feed groups including basic feed(group A,control),supplemented with 1.0%(group B),2.5%(group C) and 5.0%(group D) of compound biological product were used to make feed experiments,and the fish bodies were randomly selected from each group to determine their growth indexes and biochemical compositions of fish bodies.

     在基礎(chǔ)飼料中分別添加不同質(zhì)量分?jǐn)?shù)的復(fù)合生物制品,包括不添加(A組)、1.0%(B組)、2.5%(C組)、5.0%(D組)進(jìn)行飼喂試驗,分別從每組隨機(jī)抽取魚體,測定其生長指標(biāo)和魚體生化組成。

短句來源

     Studies on the Application of PCR Technique to Testing for Virus Pollution Causing by Veterinary Biological Product

     應(yīng)用PCR技術(shù)檢測獸醫(yī)生物制品中污染病毒的研究

短句來源

     The material of national standard endotoxin(NSE) used in our country was produced by Shanghai institute of biological product in 1997, although it satisfied the request as standard material on biological activity and its biological character was analysis partly in the beginning.

     目前我國使用的細(xì)菌內(nèi)毒素國家標(biāo)準(zhǔn)品(批號981)的原料是由上海生物制品研究所于1997年制備的，雖然在生物學(xué)活性上滿足了作為標(biāo)準(zhǔn)物質(zhì)的要求，但在制備之初僅對其生物學(xué)活性進(jìn)行了分析，沒有理化性質(zhì)分析數(shù)據(jù)，無法與國際標(biāo)準(zhǔn)品和其它國家的標(biāo)準(zhǔn)品相比對，并且使用近八年，庫存量日漸減少，也需要盡快制備新一批的國家標(biāo)準(zhǔn)品。

短句來源

     A clinical investigation of the level of lipids, glucose and uric acid influenced by a fish biological product

     鳀魚生物制品對人體血脂血糖血尿酸影響的臨床研究

短句來源

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     Applacation of GMP and TQC in the Biologicals Production Management

     良好生產(chǎn)管理規(guī)范與全面質(zhì)量管理及其在生物制品生產(chǎn)管理中的應(yīng)用

短句來源

     Mouse shall be provided by Experimental Animal Center of Changchun Biologicals Institute.

     由生物制品所實驗動物中心提供。

短句來源

     4. Yolk treated with 9.2kGy was completely up to the standard of veterinarian biologicals after sterility test, mycoplasmas test, exogenous virus test, COFAL test, safety test and potency test.

     4．9.2kGy輻照后的高免卵黃液經(jīng)無菌檢驗、支原體檢驗、外源性病毒檢驗、禽白血病病毒檢驗、安全性檢驗和效力檢驗證實完全符合獸醫(yī)生物制品的要求。

短句來源

     RESULTS:Ocurrence rate and mortality of allergic shock induced by antimicrobials,Chinese materia medica and biologicals occupied the front3places in sequence,and drugs for intravenous administration resulted in the highest rate(61.30%).

     結(jié)果 :抗微生物藥物、中草藥、生物制品的過敏性休克發(fā)生率及死亡率居前3位 ; 靜脈用藥發(fā)生率最高 ,占61 30% ;

短句來源

     The method has the po- tential for detection of residual DNA in other biologicals prepared with continuous cell lines.

     本法同樣適用于傳代細(xì)胞制備的其它生物制品中細(xì)胞殘余DNA的檢測。

短句來源

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     Strategies and Measures of Biosafety Control to Genetically Modified Veterinary Biologics II Biosafety assessment

     獸用基因工程生物制品的安全控制對策與措施( II )——生物安全性評價

短句來源

     Strategies and Measures of Biosafety Control to Genetically Modified Veterinary Biologics III. Biosafety control measures

     獸用基因工程生物制品的安全控制對策與措施(III)——生物安全控制措施

短句來源

     Conclusion All the quality indexes of SARS virus NS-1 strain complied with the Technical Point in Pre-clinical Study of Inactivated SARS Vaccine and the Chinese Requirements for Biologics 2000.It may be used as the seeds for production of inactivated SARS vaccine.

     結(jié)論SARS病毒NS1株各項指標(biāo)均符合《SARS病毒滅活疫苗臨床前研究技術(shù)要點》和《中國生物制品規(guī)程》2000年版要求,可作為SARS滅活疫苗生產(chǎn)用毒種。

短句來源

     Results A total of 79 cell lines from the cell bank for production of biologics were tested from 2003 to March 2006,of which 10 lines(12.7%) were contaminated with mycoplasma and 5 lines(6.3%) with adventitious viruses.

     結(jié)果自2003~2006年3月間共檢測了用于生物制品生產(chǎn)用細(xì)胞庫細(xì)胞79株。 結(jié)果顯示,被檢測的79株細(xì)胞中,支原體污染細(xì)胞10株,污染陽性率為12.7%;

短句來源

     Strategies and Measures of Biosafety Control to Genetically Modified Veterinary Biologics I. Biosafety control by laws, regulations and directives and biosafety regulation

     獸用基因工程生物制品的安全控制對策與措施(I)——法律法規(guī)體系的建立和安全管理

短句來源

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  biological products

High-performance size exclusion chromatography of biological products

      

High-performance size exclusion chromatography has been applied to the analysis and separation of a range of 'biological products' - substances and preparations used in human medicine that cannot be completely defined by chemical and physical means.

      

Freeze-Drying/ Lyophilization of Pharmaceutical and Biological Products, Louis Rey and Joan C.

      

The calculation algorithms developed allow one to determine the aerodynamic and temperature-moisture characteristics with account for natural convection and arbitrary shape of storehouses in order to optimize the storing of biological products.

      

The materials were thus deemed suitable for detailed characterization of elemental concentration to lead to recommended values and to bring these biological products to reference material status.

      

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  biological product

FDA regulation of allogeneic islets as a biological product

      

The major production costs (50-90%) for typical biological product resides in the purification strategy.

      

Simulation of the heat-and-mass transfer in the mound of stored biological product with centers of spontaneous heating

      

The mathematical model of the interdependent heat-and-mass transfer in a mound of stored biological product in view of the centers of spontaneous heating is offered.

      

The biological product enhanced oil degradation relative to the control, but to a lesser extent than the nutrient additions alone.

      

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  biologicals

In therapierefrakt?ren Situationen kommen neuerdings Biologicals erfolgversprechend zum Einsatz.

      

Air-lift bioreactors containing suspended or immobilized animal cells have been used for the production of a variety of high-value biologicals.

      

Neuere Kasuistiken beschreiben den lokalen Einsatz von Calcineurinantagonisten und Imiquimod und den systemischen Einsatz von Biologicals zur erfolgreichen Therapie des Granuloma anulare.

      

In this role, the development of the interferons has provided a model for other biologicals which are currently entering phase I clinical trials.

      

The objective of this study was to assess the long-term safety and tolerability of biologicals in a clinical setting.

      

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  biologics

Recent debates have centered on where biologics should be positioned within the current treatment strategy so as to maximize efficacy while balancing risk.

      

This review highlights the current position biologics hold relative to conventional therapies within the current "step-up" treatment strategy.

      

Dehydroepiandrosterone and biologics in the treatment of systemic lupus erythematosus

      

Use of biologics in the treatment of childhood rheumatic diseases

      

The current systemic anti-tumor necrosis factor (TNF)-α therapies with biologics ameliorate disease in 60% to 70% of RA patients.

      

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  本文關(guān)鍵詞：應(yīng)用PCR技術(shù)檢測獸醫(yī)生物制品中污染病毒的研究，由筆耕文化傳播整理發(fā)布。

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本文編號：241887