【摘要】：犬黃體具有異于其他家畜的生理結(jié)構(gòu)和功能表現(xiàn),其中最特別的是犬缺乏急性黃體溶解機制。犬黃體發(fā)生過程受催乳素、促黃體素和前列腺素E2的復(fù)雜調(diào)控,溶解退化過程則對其他家畜主要的溶黃體激素——前列腺素F2α不敏感。而黃體的存留對母犬的生殖活動卻具有重要的意義,其自分泌或旁分泌的類固醇激素也在妊娠調(diào)控和發(fā)情周期的更迭中發(fā)揮重要作用。犬黃體的退化機制尚未明確,但國外已有包括被動退化在內(nèi)的諸多假說。此外,黃體是為數(shù)不多具有完整生命周期的功能性組織(或器官),其發(fā)生過程、功能實現(xiàn)和衰老溶解都在周而復(fù)始地進行,這對炎癥反應(yīng)、癌癥發(fā)生和細胞凋亡等研究都具有重要的參考價值。作者綜述了犬黃體的發(fā)生和退化過程中調(diào)控機制的研究進展,旨在為進一步深入研究犬黃體發(fā)生和退化的分子機制提供研究背景和理論依據(jù)。
[Abstract]:The canine luteal body has different physiological structure and function from other domestic animals, especially the acute luteolysis mechanism of canine luteal body. The process of canine luteinogenesis is regulated by prolactin, luteinizing hormone and prostaglandin E2, while the process of dissolution and degeneration is insensitive to prostaglandin F 2 偽, the main luteolytic hormone in other domestic animals. However, the retention of corpus luteum plays an important role in the regulation of pregnancy and the change of estrus cycle, and its autocrine or paracrine steroids also play an important role in the reproductive activity of female dogs. The degeneration mechanism of canine corpus luteum is not clear, but there are many hypotheses including passive degeneration abroad. In addition, the luteal body is one of the few functional tissues (or organs) with a complete life cycle whose processes of development, function realization and aging dissolution are repeated, which respond to inflammation. The study of cancer occurrence and apoptosis has important reference value. This paper reviews the progress in the regulation mechanism of canine corpus luteum in order to provide the background and theoretical basis for further study on the molecular mechanism of canine corpus luteum.
【作者單位】： 中國農(nóng)業(yè)大學(xué)動物醫(yī)學(xué)院;中國農(nóng)業(yè)大學(xué)動物醫(yī)院;
【基金】：國家重點研發(fā)計劃(2016YFD0501000)
【分類號】：S829.2
，

本文編號：2401380