【摘要】：細(xì)胞色素P4503A(CYP3A)是細(xì)胞色素P450(CYP)酶超家族在動(dòng)物肝臟中最主要的功能形式,約占肝臟總CYP酶含量的30%,參與45%~60%常用藥物在體內(nèi)的代謝轉(zhuǎn)化過(guò)程。人們對(duì)各種CYP3A酶開(kāi)展較為系統(tǒng)的研究,包括CYP3A酶分子結(jié)構(gòu)、遺傳多樣性、體內(nèi)外活性及其影響因素等。論文從CYP3A亞家族的生物學(xué)特性、對(duì)內(nèi)源性化合物和外源性化學(xué)物質(zhì)代謝的意義、CYP3A基因的表達(dá)與調(diào)控、CYP3A酶的誘導(dǎo)與抑制及雙峰駝CYP3A酶研究進(jìn)展等方面加以綜述。
[Abstract]:Cytochrome P450 3A (CYP3A) is the most important functional form of cytochrome P450 (CYP) superfamily in animal liver. It accounts for about 30% of the total CYP enzyme content in the liver and participates in the metabolism and transformation process of 450.60% commonly used drugs in vivo. Various CYP3A enzymes have been systematically studied, including the molecular structure, genetic diversity, in vitro and in vivo activities of CYP3A enzymes and their influencing factors. In this paper, the biological characteristics of CYP3A subfamily, the significance of endogenous compounds and exogenous chemicals metabolism, the expression and regulation of CYP3A gene, the induction and inhibition of CYP3A enzyme and the research progress of CYP3A enzyme in Bactrian camel are reviewed.
【作者單位】： 內(nèi)蒙古農(nóng)業(yè)大學(xué)獸醫(yī)學(xué)院;農(nóng)業(yè)部動(dòng)物疾病臨床診療技術(shù)重點(diǎn)實(shí)驗(yàn)室;
【基金】：國(guó)家自然科學(xué)基金項(xiàng)目(31260623)
【分類號(hào)】：S852.2
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本文編號(hào)：2396633