【摘要】：通常雞群通過垂直傳播感染ALV-J后的致病性比通過水平傳播更為嚴(yán)重。本研究通過對SPF雞胚卵黃囊接種模擬了ALV-J經(jīng)垂直傳播感染雞群后的致病性,在此基礎(chǔ)上通過聯(lián)合使用逆轉(zhuǎn)錄酶抑制劑類藥物Zidovudine(AZT)和Lamivudine(LAM)并觀察其對減緩ALV-J垂直傳播致病性方面的作用。結(jié)果顯示未使用藥物的病毒感染組其體重、死亡率以及免疫ND和AI-H9滅活疫苗所產(chǎn)生的抗體水平均顯著低于使用藥物的病毒感染組(P0.05),更顯著低于未接毒的生理鹽水對照組(P0.05)。研究表明AZT和LAM等逆轉(zhuǎn)錄酶抑制劑類藥物的使用有助于降低ALV-J垂直傳播感染對雞群的危害。
[Abstract]:In general, the pathogenicity of chickens infected with ALV-J through vertical transmission is more serious than that through horizontal transmission. In this study, the pathogenicity of ALV-J infected chickens by vertical transmission was simulated by inoculating the yolk sac of SPF embryos. On this basis, the role of Zidovudine (AZT) and Lamivudine (LAM) in reducing the pathogenicity of vertical transmission of ALV-J was observed by combined use of reverse transcriptase inhibitors (Zidovudine (AZT) and Lamivudine (LAM). The results showed that the body weight, mortality rate and antibody level of ND and AI-H9 inactivated vaccine were significantly lower in viral infection group than those in viral infection group (P0.05). It was significantly lower than the control group (P0.05). The results showed that the use of reverse transcriptase inhibitors such as AZT and LAM could reduce the harm of ALV-J vertical transmission to chickens.
【作者單位】： 山東農(nóng)業(yè)大學(xué)動物醫(yī)學(xué)院;中國農(nóng)業(yè)科學(xué)院家禽科學(xué)研究所;
【基金】：國家自然科學(xué)基金青年科學(xué)基金項目(31402226) 十三五國家重點研發(fā)計劃(2016YFD0501606) 江蘇省自然科學(xué)基金(BK20151317)
【分類號】：S858.31

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