【摘要】：鹿茸每年從角柄殘樁上完全再生,是目前發(fā)現(xiàn)的唯一能夠完全再生的哺乳動物器官,是研究自然界哺乳動物肢體/附屬器官完全再生問題的理想模型。研究顯示,鹿茸芽基來源于角柄骨膜細(xì)胞的增殖與分化。角柄骨膜細(xì)胞可以表達(dá)多種胚胎干細(xì)胞標(biāo)記物并且能夠在離體情況下被誘導(dǎo)分化成多種體細(xì)胞,為鹿茸干細(xì)胞。鹿茸干細(xì)胞只有與緊密包裹的角柄皮膚細(xì)胞建立起相互作用后才能發(fā)起鹿茸的再生。鹿茸早期的再生過程在組織學(xué)上與小鼠(Mus musculus)斷肢傷口愈合過程相似,區(qū)別在于角柄骨膜細(xì)胞與長骨骨膜細(xì)胞的增殖潛能。有效提高小鼠斷肢長骨骨膜細(xì)胞的增殖潛能,使之接近角柄骨膜細(xì)胞,或許可以實(shí)現(xiàn)哺乳動物的肢體部分完全再生。本文綜述了鹿茸各組織再生和鹿茸干細(xì)胞的研究進(jìn)展,比較了鹿茸再生與蠑螈(Notophthalmus uiridescens)肢體再生的異同并且對鹿茸再生模型到臨床用提出了展望。本文為解決人類(Homo sapiens)斷指和斷肢再生提供了理論依據(jù)。
[Abstract]:It is the only mammal organ that can be completely regenerated from antler stump every year. It is an ideal model to study the complete regeneration of limb / accessory organ in nature. The results showed that the budding of velvet antler originated from the proliferation and differentiation of periosteal cells in the stalks. Corner stalk periosteum cells can express a variety of embryonic stem cell markers and can be induced to differentiate into a variety of somatic cells in vitro as velvet antler stem cells. Antler stem cells can initiate antler regeneration only when they interact with closely encapsulated hornstalk skin cells. The regeneration process of velvet antler in early stage was similar to that of mouse (Mus musculus) amputated limb wound healing histologically. The difference was the proliferative potential between hornstalk periosteum cells and long bone periosteal cells. It can effectively improve the proliferative potential of the long bone periosteal cells in the amputated limb and approach the hornstalk periosteum cells, which may be able to realize the partial regeneration of the limb of the mammal. In this paper, the research progress of pilose antler tissue regeneration and pilose antler stem cells was reviewed, and the similarities and differences between velvet antler regeneration and salamander (Notophthalmus uiridescens) limb regeneration were compared, and the prospect of pilose antler regeneration model for clinical application was put forward. This paper provides a theoretical basis for solving human (Homo sapiens) amputation and limb regeneration.
【作者單位】： 中國農(nóng)業(yè)科學(xué)院特產(chǎn)研究所/特種經(jīng)濟(jì)動物分子生物學(xué)國家重點(diǎn)實(shí)驗(yàn)室;
【基金】：國家高技術(shù)研究發(fā)展計(jì)劃(863)項(xiàng)目(No.2011AA100603) 國家自然科學(xué)基金項(xiàng)目(No.31170950) 吉林省重點(diǎn)科技攻關(guān)項(xiàng)目(No.2015020407NY) 吉林省自然科學(xué)基金項(xiàng)目(No.20140101139JC)
【分類號】：S825

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