【摘要】：炎癥是一種機(jī)體對(duì)感染或組織損傷的保護(hù)性反應(yīng)。適度的或可控的炎癥對(duì)于入侵病原微生物的清除以及受損組織的修復(fù)是必需的,然而過(guò)度的或不可控的炎癥往往會(huì)導(dǎo)致病理性炎癥反應(yīng)發(fā)生,大大提高了各種感染性和代謝性疾病的發(fā)病風(fēng)險(xiǎn)。多不飽脂肪酸代謝生成的脂質(zhì)調(diào)控介質(zhì)對(duì)炎癥的啟動(dòng)、發(fā)展以及消退均具有重要的調(diào)節(jié)作用,了解多不和脂肪酸的代謝及其代謝產(chǎn)物對(duì)炎癥反應(yīng)的調(diào)節(jié)機(jī)制,對(duì)于通過(guò)飼糧營(yíng)養(yǎng)途徑控制疾病發(fā)生以及改善人和動(dòng)物健康具有重要的理論和現(xiàn)實(shí)意義。鑒此,本文綜述了多不飽和脂肪酸的代謝途徑,并就其代謝產(chǎn)物對(duì)炎癥反應(yīng)的調(diào)節(jié)進(jìn)行了詳細(xì)論述。
[Abstract]:Inflammation is a protective response of the body to infection or tissue damage. Moderate or controllable inflammation is necessary for the clearance of invading pathogenic microorganisms and the repair of damaged tissue. However, excessive or uncontrollable inflammation often leads to pathological inflammation. It greatly increases the risk of various infectious and metabolic diseases. Lipid regulatory mediators produced by the metabolism of polyunsaturated fatty acids play an important role in the initiation, development and regression of inflammation. It has important theoretical and practical significance for controlling disease and improving human and animal health through dietary nutrition. In this paper, the metabolic pathways of polyunsaturated fatty acids are reviewed, and the regulation of their metabolites on inflammation is discussed in detail.
【作者單位】： 內(nèi)蒙古師范大學(xué)生命科學(xué)與技術(shù)學(xué)院;
【基金】：國(guó)家自然科學(xué)基金項(xiàng)目(31560644) 內(nèi)蒙古自然科學(xué)基金項(xiàng)目(2015MS0367) 引進(jìn)高層次人才科研啟動(dòng)經(jīng)費(fèi)項(xiàng)目(2015YJRC005)
【分類號(hào)】：S816
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本文編號(hào)：2261363