發(fā)布時(shí)間：2018-09-05 14:09

【摘要】：將36只健康雄性小型雜種犬隨機(jī)平均分為模型組與對(duì)照組,模型組犬右后肢膝關(guān)節(jié)使用改良后的前十字韌帶切斷法誘導(dǎo)骨關(guān)節(jié)炎,對(duì)照組僅做切開(kāi)右后肢膝關(guān)節(jié)囊后縫合處理。在造模后第4、8、12周對(duì)2組犬進(jìn)行關(guān)節(jié)活動(dòng)度檢查、肉眼檢查、X射線檢查與K/L分級(jí)評(píng)分。結(jié)果顯示:隨造模時(shí)間延長(zhǎng),模型組犬膝關(guān)節(jié)腫脹、活動(dòng)受限,出現(xiàn)跛行,肉眼檢查觀查同X射線結(jié)果一致呈加重表現(xiàn),為關(guān)節(jié)間隙變窄、骨贅增多、軟骨下骨密度升高,與對(duì)照組比較均差異顯著(P0.05)。X射線對(duì)中晚期骨關(guān)節(jié)炎病變敏感,為骨關(guān)節(jié)炎預(yù)后及治療提供一種安全、簡(jiǎn)便的方法。
[Abstract]:Thirty-six small male mongrel dogs were randomly divided into model group and control group. The right hind limb knee joint of the model group was induced by modified anterior cruciate ligament amputation, while the control group was treated with posterior capsular suture of the knee joint of the right hind limb. The articular motion, naked eye examination and K / L grading were performed at 812 weeks after modeling. The results showed that the knee joint swelling, limited movement and claudication were observed in the model group with the prolongation of the model time. The results of naked eye examination and X-ray showed that the joint space became narrow, the osteophyte increased, and the bone mineral density increased under the cartilage. Compared with the control group, the difference was significant (P0.05). X-ray was sensitive to the middle and advanced osteoarthritis, which provided a safe and simple method for the prognosis and treatment of osteoarthritis.
【作者單位】： 黑龍江八一農(nóng)墾大學(xué)動(dòng)物科技學(xué)院;
【基金】：黑龍江省農(nóng)墾總局科技計(jì)劃項(xiàng)目(HNK125B-12ZD-09)
【分類(lèi)號(hào)】：S858.292
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本文編號(hào)：2224514