【摘要】：通過放射性標(biāo)記示蹤方法研究喹賽多(cyadox,CYX)在雞體內(nèi)的處置過程,探討喹賽多的藥理學(xué)與毒理學(xué)特性,為其合理用藥和食品安全評價(jià)提供理論依據(jù)。在物料平衡研究中,一組6羽雞一次性灌服[~3H]-CYX,每24 h收集糞便檢測其放射性。在組織分布消除研究中,5組20羽雞連續(xù)灌服[~3H]-CYX 7 d,不同時(shí)間點(diǎn)宰殺一組,檢測各組織器官中的放射性。結(jié)果顯示,雞體內(nèi)喹賽多的排泄速率快且較為徹底。糞便中排出的放射性藥物占總給藥劑量的95.94%,總回收率達(dá)到96.02%,未回收3.98%。連續(xù)灌服7 d后,喹賽多在雞組織中分布廣泛,停藥后第6小時(shí)所檢測的所有組織中都能檢測到一定量的放射性,肝和腎中殘留時(shí)間最長,但消除迅速。停藥后第7天,大部分組織器官中的放射性均低于檢測限。在雞體內(nèi),停藥后第6小時(shí)放射性總殘留質(zhì)量分?jǐn)?shù)低于安全質(zhì)量分?jǐn)?shù)。喹賽多在雞體內(nèi)處置的研究表明,喹賽多在雞體內(nèi)吸收快,分布廣泛,消除迅速,排泄較為徹底。
[Abstract]:The disposal process of Cyadoxo CYX in chickens was studied by radiotracer method. The pharmacological and toxicological characteristics of Cyadoxdo were discussed, which provided a theoretical basis for rational drug use and food safety evaluation. In the study of material balance, a group of 6 chickens were injected with [3H] -CYX at one time, and their feces were collected every 24 hours to detect their radioactivity. In the study of tissue distribution elimination, 20 chickens of 5 groups were continuously administered [3H] -CYX for 7 days. One group was slaughtered at different time points to detect radioactivity in tissues and organs. The results showed that the excretion rate of Quisedo in chicken was faster and more thorough. The total recovery rate of radioactive drugs in feces was 96.02 and the recovery was not 3.98. After 7 days of continuous administration, Quisedo was widely distributed in chicken tissues. A certain amount of radioactivity could be detected in all the tissues detected at 6 hours after withdrawal, and the residue time in liver and kidney was the longest, but it was eliminated rapidly. The radioactivity in most tissues and organs was lower than the detection limit on the 7th day after withdrawal. In chickens, the total residual radioactivity mass fraction at 6 hours after withdrawal was lower than the safe mass fraction. The study on the disposal of Quisedo in chicken showed that the absorption of Quizedo was fast, the distribution was wide, the elimination was rapid, and the excretion was more thorough.
【作者單位】： 湖北工程學(xué)院生命科學(xué)技術(shù)學(xué)院湖北省植物功能成分利用工程技術(shù)研究中心;國家獸藥殘留基準(zhǔn)實(shí)驗(yàn)室農(nóng)業(yè)部食品獸藥殘留檢測重點(diǎn)實(shí)驗(yàn)室農(nóng)業(yè)部畜禽產(chǎn)品質(zhì)量安全風(fēng)險(xiǎn)評估實(shí)驗(yàn)室華中農(nóng)業(yè)大學(xué)獸藥研究所;
【基金】：國家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃(973)項(xiàng)目(2009CB118800)
【分類號】：S816.7
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本文編號：2170239