本文選題：豬 + 烯丙孕素　； 參考：《中國(guó)獸藥雜志》2017年10期

【摘要】：為評(píng)價(jià)烯丙孕素口服液對(duì)豬的安全性,將24頭達(dá)到性成熟的蘇姜母豬隨機(jī)分為4組,每組6頭,采用多劑量水平給藥進(jìn)行靶動(dòng)物安全性研究,其中受試藥物設(shè)最大推薦劑量每頭動(dòng)物每日20 mg烯丙孕素(相當(dāng)于每次5 m L)、2倍最大推薦劑量每頭動(dòng)物每日40 mg烯丙孕素(相當(dāng)于每次10 m L)和3倍最大推薦劑量每頭動(dòng)物每日60 mg烯丙孕素(相當(dāng)于每次15 m L)三個(gè)劑量組;另設(shè)一空白對(duì)照組,每頭動(dòng)物每日15 m L潔凈自來(lái)水,體積相當(dāng)于3倍受試藥推薦劑量的體積。通過(guò)一般臨床觀察、各組動(dòng)物體重、血液學(xué)和血液生化學(xué)參數(shù)等指標(biāo)及組織病理學(xué)檢測(cè)或觀察,評(píng)價(jià)烯丙孕素在臨床用藥的安全性。結(jié)果表明,試驗(yàn)期間各組豬均未死亡且健康良好,期間臨床表現(xiàn)正常,3倍最大推薦劑量組剖檢動(dòng)物各組織器官未發(fā)現(xiàn)病理變化。在血液生理指標(biāo)及生化指標(biāo)方面,推薦劑量組、2倍推薦劑量組、3倍最大推薦劑量組與空白對(duì)照組相比,除少部分指標(biāo)外,其他各指標(biāo)并無(wú)顯著差異。試驗(yàn)結(jié)果說(shuō)明,烯丙孕素在推薦劑量下使用在靶動(dòng)物豬上具有較高的安全性。
[Abstract]:In order to evaluate the safety of allylpregnancy oral liquid in pigs, 24 sujiang sows with sexual maturity were randomly divided into 4 groups, 6 in each group, and the safety of target animals was studied by multi-dose administration. Of these drugs, the maximum recommended dose per animal was 20 mg / day (equivalent to 2 times the maximum recommended dose of 5 m L / d) and the maximum recommended dose of 40 mg / day (10 mL / day) and 3 times the maximum recommended dose per animal. Each animal was given 60 mg of allopretin per day (equivalent to 15 mL each time) in three dose groups; A blank control group was set up with 15 mL clean tap water per day for each animal. The volume was equivalent to the volume of 3 recommended doses for each animal. The safety of allylpregnancy was evaluated by general clinical observation, body weight, hematological and biochemical parameters and histopathological examination. The results showed that the pigs in each group were not dead and healthy during the trial period, and no pathological changes were found in all tissues and organs of the animals in the group with 3 times normal clinical manifestations and the maximum recommended dose. In terms of blood physiological and biochemical indexes, there was no significant difference between the recommended dose group and the blank control group, except for a few indexes, the maximum recommended dose group was 3 times and the maximum recommended dose group was 3 times as compared with the blank control group. The results show that allylpregnancy has high safety in target pigs at recommended dose.
【作者單位】： 揚(yáng)州大學(xué)獸醫(yī)學(xué)院;江蘇省動(dòng)物重要疫病與人獸共患病防控協(xié)同創(chuàng)新中心;寧波第二激素廠;
【基金】：基金項(xiàng)目:江蘇高校優(yōu)勢(shì)學(xué)科建設(shè)工程(PAPD)
【分類(lèi)號(hào)】：S859.7

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