發(fā)布時(shí)間：2018-05-19 21:43

  本文選題：利福昔明 + 混懸乳劑��； 參考：《中國獸藥雜志》2017年07期

【摘要】：建立了測定利福昔明混懸乳劑含量的高效液相色譜法(HPLC)。采用C18色譜柱(4.6 mm×150 mm,5μm),以甲醇-乙腈-0.075 mol/L磷酸二氫鉀溶液-1 mol/L檸檬酸溶液(32∶28∶25∶4)為流動(dòng)相,流速1.0 m L/min,檢測波長236 nm,進(jìn)樣量20μL,柱溫25℃。利福昔明濃度在5~100μg/m L時(shí),其峰面積與濃度線性關(guān)系良好(r2=0.9996),無雜質(zhì)干擾,穩(wěn)定性高,回收率范圍為98.4%~100.2%,RSD為0.58%~1.32%。本操作方法簡便、分析快速、結(jié)果準(zhǔn)確,適用于利福昔明混懸乳劑的含量測定。
[Abstract]:A high performance liquid chromatography (HPLC) method for the determination of rifaximin suspension emulsion was established. A C18 column of 4.6 mm 脳 150mm ~ 5 渭 m ~ (-1) was used. The mobile phase was methanol-acetonitrile-0.075 mol/L potassium dihydrogen phosphate solution -1 mol/L citric acid solution (32: 28: 25: 4), the flow rate was 1.0 mL / min, the detection wavelength was 236 nm, the injection amount was 20 渭 L, and the column temperature was 25 鈩，

本文編號(hào)：1911834