本文選題：麻葉蕁麻 + 小鼠　； 參考：《動(dòng)物醫(yī)學(xué)進(jìn)展》2017年09期

【摘要】：為了比較蕁麻干燥處理以及高溫提取對(duì)其藥效學(xué)的影響,探究了麻葉蕁麻鮮株榨汁制備的鮮汁、干粉水浸制備的干汁以及干粉煮沸后獲得的煮汁對(duì)小鼠離體小腸運(yùn)動(dòng)的影響。結(jié)果顯示,3種汁均可劑量依賴性促進(jìn)小腸的運(yùn)動(dòng),其最小有效濃度約為2g/mL,最大有效濃度約為50g/mL。2g/mL的3種汁使小腸收縮張力均較用藥前顯著增加(P0.05),且鮮汁和干汁用藥后小腸收縮張力均顯著高于煮汁(P0.05)。50g/mL干汁用藥后1min內(nèi)收縮曲線下面積顯著高于50g/mL鮮汁,其他兩兩比較差異均不顯著(P0.05)。試驗(yàn)結(jié)果表明高溫水煮可影響蕁麻在促進(jìn)胃腸動(dòng)力方面作用,而干株可替代鮮株作用,提示在制備用于緩解或治療胃腸動(dòng)力障礙蕁麻藥材時(shí),可用干株水浸方法制備。
[Abstract]:In order to compare the effects of drying and high temperature extraction on the pharmacodynamics of nettles, the effects of fresh juice extracted from fresh plants of nettle leaves on the movement of isolated small intestine of mice were studied. The results showed that all three kinds of juice could promote the small intestine movement in a dose-dependent manner. The minimum effective concentration is about 2 g / mL, and the three kinds of juice with the maximum effective concentration of 50g/mL.2g/mL can significantly increase the tension of small intestine contraction compared with that before administration. The contraction tension of small intestine in fresh juice and dry juice is significantly higher than that in 1min after the treatment of boiled juice (P0.05U. 50 g / mL). The area under the contraction curve was significantly higher than that of 50g/mL fresh juice. There was no significant difference between the other two groups (P 0.05). The results showed that high temperature boiling could affect the effect of urticaria in promoting gastrointestinal motility, while dry plant could replace fresh plant, suggesting that dry plant water leaching could be used to prepare herbs for relieving or treating gastrointestinal motility disorder urticaria.
【作者單位】： 新疆農(nóng)業(yè)大學(xué)動(dòng)物醫(yī)學(xué)學(xué)院;喀什地區(qū)畜牧工作站;
【基金】：新疆維吾爾自治區(qū)自然科學(xué)基金項(xiàng)目(2016D01A030)
【分類號(hào)】：S853.74

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