發(fā)布時(shí)間：2018-04-26 03:37

  本文選題：八眉豬 + KMT��； 參考：《西北農(nóng)業(yè)學(xué)報(bào)》2017年06期

【摘要】：為探討復(fù)合麻醉劑KMT對(duì)八眉豬血流動(dòng)力學(xué)的影響及其作用機(jī)制,給8只8~10周齡的八眉豬根據(jù)體質(zhì)量肌肉注射KMT 0.1mL/kg,在注藥前及注藥后5、10、15、30、45、60、80、100、120min進(jìn)行無創(chuàng)血壓、HR的監(jiān)測(cè),并同步采取前腔靜脈血樣,采用放免法測(cè)定血漿中PRA、AⅡ和ALD的質(zhì)量濃度。結(jié)果發(fā)現(xiàn),血壓和HR在注藥后10min時(shí)達(dá)到最高值,之后開始逐漸下降,到80min時(shí)降至最低,之后開始升高。PRA、AⅡ和ALD與SBP、DBP、MAP及HR的變化趨勢(shì)大致相似,且存在一定的相關(guān)性。表明PRA、AⅡ和ALD參與KMT引起的八眉豬血流動(dòng)力學(xué)變化過程,腎素-血管緊張素-醛固酮系統(tǒng)的變化可能是KMT引起八眉豬血流動(dòng)力學(xué)變化的主要作用機(jī)制之一。
[Abstract]:In order to investigate the effect of compound anesthetic KMT on the hemodynamics of eight eyebrow pigs and the mechanism of action, 8 weeks old eight eyebrow pigs were injected with KMT 0.1mL/kg according to body mass. Before and after injection, the non invasive blood pressure and HR were monitored, and the anterior vena cava blood samples were collected synchronously, and the blood plasma was measured by radioimmunoassay. The mass concentration of medium PRA, A II and ALD found that blood pressure and HR reached the highest value at 10min after the injection, and then began to decline gradually, to the lowest level to 80min, and then to begin to increase.PRA. A II and ALD were similar to SBP, DBP, MAP, and there was a certain correlation. The changes in hemodynamics and the changes of renin angiotensin aldosterone system may be one of the main mechanisms of KMT induced hemodynamic changes in eight eyebrow pigs.

【作者單位】： 西北農(nóng)林科技大學(xué)動(dòng)物醫(yī)學(xué)院;
【分類號(hào)】：S859.791
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本文編號(hào)：1804355