本文選題：不孕癥　切入點(diǎn)：產(chǎn)后保健　出處：《內(nèi)蒙古農(nóng)業(yè)大學(xué)》2015年碩士論文

【摘要】：內(nèi)蒙古為奶牛養(yǎng)殖大區(qū),呼和浩特市被譽(yù)為中國(guó)的乳都,奶牛養(yǎng)殖在畜牧業(yè)生產(chǎn)中占有舉足輕重的地位。但奶牛不孕癥是嚴(yán)重影響奶牛業(yè)發(fā)展的頑疾之一,本病發(fā)病率高、淘汰率高,常常造成巨大的經(jīng)濟(jì)損失。不孕癥的發(fā)生發(fā)展與圍產(chǎn)期疾病有密切關(guān)系。圍產(chǎn)期是奶牛泌乳、繁殖、飼養(yǎng)和管理的過(guò)渡期,圍產(chǎn)期中分娩期和產(chǎn)褥期是奶牛能否順利過(guò)渡到泌乳期的關(guān)鍵時(shí)段。本論文對(duì)①內(nèi)蒙古巴彥淖爾和呼和浩特兩地6座規(guī)�；B(yǎng)牛場(chǎng)奶牛不孕癥進(jìn)行了調(diào)查；②對(duì)患產(chǎn)褥期子宮炎和臨床子宮內(nèi)膜炎的病牛及順產(chǎn)健康對(duì)照組牛產(chǎn)后血漿中細(xì)胞因子(IL-1β、IL-6、IL-10、TNF-α、TGF-β),急性期蛋白Hp,抗氧化等指標(biāo)(T-AOC、GSH-Px、CAT、SOD、MDA)進(jìn)行了檢測(cè)；③灌服中藥復(fù)方后對(duì)正常分娩牛和分娩后空白對(duì)照牛血漿中的上述指標(biāo)進(jìn)行檢測(cè)。結(jié)果：①內(nèi)蒙古巴彥淖爾和呼和浩特兩地不孕癥奶牛分別占被調(diào)查�？倲�(shù)的20.29%和19.80%；產(chǎn)后恢復(fù)期的生殖系統(tǒng)疾病導(dǎo)致空懷天數(shù)延長(zhǎng)；不孕淘汰的各種疾病牛(除習(xí)慣性流產(chǎn)外)空懷均超過(guò)150 d以上,而且不孕牛的平均累積配次和胎次之間差異較顯著。②產(chǎn)褥期子宮炎牛(病牛)T-AOC、GSH-Px在產(chǎn)后7d顯著高于對(duì)照組,CAT在產(chǎn)后3d顯著高于對(duì)照組；而SOD差異不顯著。病牛組內(nèi)MDA隨時(shí)間變化不顯著,對(duì)照組內(nèi)MDA產(chǎn)后顯著降低。病牛與對(duì)照組之間IL-1β、IL-6、 IL-10、TNF-α、TGF-β、Hp沒(méi)有顯著差異。臨床子宮內(nèi)膜炎牛與對(duì)照血漿T-AOC、 SOD、GSH-Px、CAT、MDA、IL-1β、 IL-6、IL-10差異不顯著；Hp、TGF-β顯著高于對(duì)照組；TNF-a極顯著高于對(duì)照組。③用藥后高、中、低劑量組產(chǎn)后14dHp均顯著低于對(duì)照組。用藥組內(nèi)GSH-Px、CAT、T-AOC、IL-1β、IL-6顯著升高,對(duì)照組內(nèi)變化不顯著。用藥組21 d IL-1β、Hp顯著高于對(duì)照組；IL-107 d顯著高于對(duì)照組；TNF-α、TGF-β組間差異不顯著。中藥復(fù)方能降低產(chǎn)褥期子宮炎的發(fā)病率；并能縮短產(chǎn)犢受孕間隔時(shí)間。結(jié)論：不孕癥牛在調(diào)查的牛場(chǎng)中發(fā)病率仍較高,做好接產(chǎn)、產(chǎn)后保健護(hù)理和健康監(jiān)控是降低不孕癥的有效途徑。產(chǎn)褥期子宮炎奶�？寡趸芰︼@著增強(qiáng)；脂質(zhì)過(guò)氧化物變化不明顯,表明其抗病能力代償性增強(qiáng)。中藥復(fù)方可提高產(chǎn)后奶牛子宮固有免疫機(jī)能,與止痛藥物聯(lián)合應(yīng)可降低疼痛應(yīng)激、促進(jìn)產(chǎn)后恢復(fù)。
[Abstract]:The city of Hohhot is regarded as the milk capital of China. Dairy cow breeding plays an important role in animal husbandry, but cow infertility is one of the stubborn diseases that seriously affect the development of dairy cattle industry, and the incidence of this disease is high. The occurrence and development of infertility is closely related to perinatal diseases. Perinatal period is a transitional period for milk, reproduction, feeding and management of dairy cows. The period of parturition and puerperium during perinatal period is the key period for the smooth transition of cows to lactation. In this paper, two pairs of infertility were investigated in 6 large-scale cattle farms of Bayan Nur and Hohhot, Inner Mongolia. Plasma cytokines IL-1 尾, IL-6, IL-10, TNF- 尾, Hpand antioxidative indexes of hysteritis and clinical endometritis in puerperium and healthy control cattle after delivery were determined. The serum levels of TGF- 尾, Hpand antioxidative indexes such as T-AOCCGSH-PxCATX CATX SODDMDA3 were measured in normal delivery cattle and normal delivery cattle after oral administration of traditional Chinese medicine (TCM). Results the sterile cows in Bayan Nur of Inner Mongolia and Hohhot accounted for 20.29% and 19.80% of the total number of cows, respectively, and the days of empty pregnancy were prolonged due to reproductive system diseases during postpartum convalescence. The sterility of cattle with various diseases (except habitual abortion) was more than 150 days. Moreover, the difference between the average cumulative match and birth order of infertile cattle was significantly higher than that of the control group on the 7th day postpartum, and the difference between them was higher than that in the control group on the 3rd day after delivery. 2. The GSH-Px of hysteritis cattle at puerperium stage was significantly higher than that of the control group at 7 days postpartum. However, there was no significant difference in SOD. The changes of MDA in the diseased cattle group were not significant with time. There was no significant difference in IL-1 尾 -IL-6, IL-10 TNF- 偽 TGF- 尾 Hp between the diseased cattle and the control group. There was no significant difference between the clinical endometritis cattle and the control group in plasma T-AOC, SODD-GSH-PxCATDA-MDA-IL-1 尾, IL-6TGF- 尾, IL-6TGF- 尾, which was significantly higher than that in the control group. The postpartum 14dHp in the low dose group was significantly lower than that in the control group. The changes in the control group were not significant. The IL-1 尾 -Hp in the treatment group was significantly higher than that in the control group at day 1077.There was no significant difference between the control group and the control group. The Chinese medicine compound could reduce the incidence of puerperal hysteritis. Conclusion: the incidence rate of infertility cattle in the cattle farm investigated is still high. Postpartum health care and health monitoring are effective ways to reduce infertility. The antioxidation ability of hysteritis cows during puerperium period is significantly increased, and the changes of lipid peroxides are not obvious. The results showed that the compensatory ability of resistance to disease was enhanced. Chinese herbal compound could improve the inherent immune function of uterus in postpartum cows, and combined with analgesic drugs could reduce pain stress and promote postpartum recovery.
【學(xué)位授予單位】：內(nèi)蒙古農(nóng)業(yè)大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類(lèi)號(hào)】：S858.23

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