本文選題：不孕癥　切入點：產(chǎn)后保健　出處：《內(nèi)蒙古農(nóng)業(yè)大學》2015年碩士論文

【摘要】：內(nèi)蒙古為奶牛養(yǎng)殖大區(qū),呼和浩特市被譽為中國的乳都,奶牛養(yǎng)殖在畜牧業(yè)生產(chǎn)中占有舉足輕重的地位。但奶牛不孕癥是嚴重影響奶牛業(yè)發(fā)展的頑疾之一,本病發(fā)病率高、淘汰率高,常常造成巨大的經(jīng)濟損失。不孕癥的發(fā)生發(fā)展與圍產(chǎn)期疾病有密切關系。圍產(chǎn)期是奶牛泌乳、繁殖、飼養(yǎng)和管理的過渡期,圍產(chǎn)期中分娩期和產(chǎn)褥期是奶牛能否順利過渡到泌乳期的關鍵時段。本論文對①內(nèi)蒙古巴彥淖爾和呼和浩特兩地6座規(guī)�；B(yǎng)牛場奶牛不孕癥進行了調(diào)查；②對患產(chǎn)褥期子宮炎和臨床子宮內(nèi)膜炎的病牛及順產(chǎn)健康對照組牛產(chǎn)后血漿中細胞因子(IL-1β、IL-6、IL-10、TNF-α、TGF-β),急性期蛋白Hp,抗氧化等指標(T-AOC、GSH-Px、CAT、SOD、MDA)進行了檢測；③灌服中藥復方后對正常分娩牛和分娩后空白對照牛血漿中的上述指標進行檢測。結(jié)果：①內(nèi)蒙古巴彥淖爾和呼和浩特兩地不孕癥奶牛分別占被調(diào)查�？倲�(shù)的20.29%和19.80%；產(chǎn)后恢復期的生殖系統(tǒng)疾病導致空懷天數(shù)延長；不孕淘汰的各種疾病牛(除習慣性流產(chǎn)外)空懷均超過150 d以上,而且不孕牛的平均累積配次和胎次之間差異較顯著。②產(chǎn)褥期子宮炎牛(病牛)T-AOC、GSH-Px在產(chǎn)后7d顯著高于對照組,CAT在產(chǎn)后3d顯著高于對照組；而SOD差異不顯著。病牛組內(nèi)MDA隨時間變化不顯著,對照組內(nèi)MDA產(chǎn)后顯著降低。病牛與對照組之間IL-1β、IL-6、 IL-10、TNF-α、TGF-β、Hp沒有顯著差異。臨床子宮內(nèi)膜炎牛與對照血漿T-AOC、 SOD、GSH-Px、CAT、MDA、IL-1β、 IL-6、IL-10差異不顯著；Hp、TGF-β顯著高于對照組；TNF-a極顯著高于對照組。③用藥后高、中、低劑量組產(chǎn)后14dHp均顯著低于對照組。用藥組內(nèi)GSH-Px、CAT、T-AOC、IL-1β、IL-6顯著升高,對照組內(nèi)變化不顯著。用藥組21 d IL-1β、Hp顯著高于對照組；IL-107 d顯著高于對照組；TNF-α、TGF-β組間差異不顯著。中藥復方能降低產(chǎn)褥期子宮炎的發(fā)病率；并能縮短產(chǎn)犢受孕間隔時間。結(jié)論：不孕癥牛在調(diào)查的牛場中發(fā)病率仍較高,做好接產(chǎn)、產(chǎn)后保健護理和健康監(jiān)控是降低不孕癥的有效途徑。產(chǎn)褥期子宮炎奶牛抗氧化能力顯著增強；脂質(zhì)過氧化物變化不明顯,表明其抗病能力代償性增強。中藥復方可提高產(chǎn)后奶牛子宮固有免疫機能,與止痛藥物聯(lián)合應可降低疼痛應激、促進產(chǎn)后恢復。
[Abstract]:The city of Hohhot is regarded as the milk capital of China. Dairy cow breeding plays an important role in animal husbandry, but cow infertility is one of the stubborn diseases that seriously affect the development of dairy cattle industry, and the incidence of this disease is high. The occurrence and development of infertility is closely related to perinatal diseases. Perinatal period is a transitional period for milk, reproduction, feeding and management of dairy cows. The period of parturition and puerperium during perinatal period is the key period for the smooth transition of cows to lactation. In this paper, two pairs of infertility were investigated in 6 large-scale cattle farms of Bayan Nur and Hohhot, Inner Mongolia. Plasma cytokines IL-1 尾, IL-6, IL-10, TNF- 尾, Hpand antioxidative indexes of hysteritis and clinical endometritis in puerperium and healthy control cattle after delivery were determined. The serum levels of TGF- 尾, Hpand antioxidative indexes such as T-AOCCGSH-PxCATX CATX SODDMDA3 were measured in normal delivery cattle and normal delivery cattle after oral administration of traditional Chinese medicine (TCM). Results the sterile cows in Bayan Nur of Inner Mongolia and Hohhot accounted for 20.29% and 19.80% of the total number of cows, respectively, and the days of empty pregnancy were prolonged due to reproductive system diseases during postpartum convalescence. The sterility of cattle with various diseases (except habitual abortion) was more than 150 days. Moreover, the difference between the average cumulative match and birth order of infertile cattle was significantly higher than that of the control group on the 7th day postpartum, and the difference between them was higher than that in the control group on the 3rd day after delivery. 2. The GSH-Px of hysteritis cattle at puerperium stage was significantly higher than that of the control group at 7 days postpartum. However, there was no significant difference in SOD. The changes of MDA in the diseased cattle group were not significant with time. There was no significant difference in IL-1 尾 -IL-6, IL-10 TNF- 偽 TGF- 尾 Hp between the diseased cattle and the control group. There was no significant difference between the clinical endometritis cattle and the control group in plasma T-AOC, SODD-GSH-PxCATDA-MDA-IL-1 尾, IL-6TGF- 尾, IL-6TGF- 尾, which was significantly higher than that in the control group. The postpartum 14dHp in the low dose group was significantly lower than that in the control group. The changes in the control group were not significant. The IL-1 尾 -Hp in the treatment group was significantly higher than that in the control group at day 1077.There was no significant difference between the control group and the control group. The Chinese medicine compound could reduce the incidence of puerperal hysteritis. Conclusion: the incidence rate of infertility cattle in the cattle farm investigated is still high. Postpartum health care and health monitoring are effective ways to reduce infertility. The antioxidation ability of hysteritis cows during puerperium period is significantly increased, and the changes of lipid peroxides are not obvious. The results showed that the compensatory ability of resistance to disease was enhanced. Chinese herbal compound could improve the inherent immune function of uterus in postpartum cows, and combined with analgesic drugs could reduce pain stress and promote postpartum recovery.
【學位授予單位】：內(nèi)蒙古農(nóng)業(yè)大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：S858.23

【參考文獻】

相關期刊論文 前10條

1 王東升;梁紀蘭;嚴作廷;李世宏;謝家聲;;防治奶牛子宮內(nèi)膜炎中藥制劑的研究進展[J];安徽農(nóng)業(yè)科學;2008年25期

2 張銀亮;陳創(chuàng)夫;喬軍;劉賢俠;王利曉;余勝利;胡朝輝;;新疆北部地區(qū)奶牛子宮內(nèi)膜炎主要病原菌的分離鑒定及其血細胞成分分析[J];中國草食動物;2010年04期

3 嚴愛萍;秦永福;;共和縣奶牛不孕癥的調(diào)查[J];山東畜牧獸醫(yī);2008年06期

4 李志杰;提金鳳;;一例奶牛子宮脫出的診治與體會[J];動物醫(yī)學進展;2006年11期

5 簡子健;趙紅瓊;馬素珍;白麗;;奶牛子宮內(nèi)膜炎治療學研究進展[J];動物醫(yī)學進展;2007年04期

6 姚靜;解英波;烏日罕;特木爾巴根;馬立峰;李瑞剛;于富麗;申之義;李平安;;呼和浩特地區(qū)奶牛流產(chǎn)胎兒中布魯菌的分離鑒定[J];動物醫(yī)學進展;2008年05期

7 許臘梅;馮萬宇;王巖;王志明;段瑩瑩;侯振中;;奶牛子宮內(nèi)膜炎研究進展[J];動物醫(yī)學進展;2008年08期

8 楊炳杰;張盼鋒;蘇惠龍;仇微紅;劉宇;;奶牛卵泡囊腫病因及診療研究進展[J];動物醫(yī)學進展;2008年10期

9 鐘旭;薛立群;;奶牛子宮內(nèi)膜炎研究進展[J];動物醫(yī)學進展;2010年11期

10 金莉萍;轉(zhuǎn)化生長因子β與生殖功能調(diào)節(jié)研究進展[J];國外醫(yī)學(計劃生育分冊);2003年01期

相關會議論文 前4條

1 雷金龍;吳樹清;李國俊;楊鳳波;余興邦;趙銀鴿;;奶牛產(chǎn)道損傷診療的探討[A];全國獸醫(yī)外科學第13次學術研討會、小動物醫(yī)學第1次學術研討會暨奶牛疾病第3次學術討論會論文集[C];2006年

2 劉振君;李艷華;;奶牛產(chǎn)后卵巢繁殖障礙的發(fā)病規(guī)律及預防措施[A];中國畜牧獸醫(yī)學會動物繁殖學分會第十六屆學術研討會論文集[C];2012年

3 榮海林;李慧穎;榮柏郁;付國華;柴偉;劉國晉;尹鳳桐;;母牛分娩的助產(chǎn)及難產(chǎn)處理技術要點[A];《2009中國牛業(yè)進展》論文集[C];2009年

4 陶斌;;再談奶牛繁殖障礙的綜合防治[A];第三屆中國奶牛發(fā)展大會論文集[C];2008年

相關博士學位論文 前4條

1 郭世寧;防治奶牛子宮內(nèi)膜炎新型復方藥物制劑宮炎清的研究[D];東北農(nóng)業(yè)大學;2002年

2 孔祥峰;中藥新促孕液防治母畜子宮內(nèi)膜炎的機理研究[D];南京農(nóng)業(yè)大學;2006年

3 趙樹臣;中藥組方治療奶牛子宮內(nèi)膜炎的研究[D];內(nèi)蒙古農(nóng)業(yè)大學;2007年

4 李德軍;奶牛隱性和臨床型子宮內(nèi)膜炎病理機制研究[D];華中農(nóng)業(yè)大學;2010年

相關碩士學位論文 前7條

1 楊威;姜黃素治療奶牛子宮內(nèi)膜炎的研究[D];河北農(nóng)業(yè)大學;2012年

2 張冬波;奶牛子宮內(nèi)膜炎組織相關因子的研究[D];東北農(nóng)業(yè)大學;2006年

3 田永強;治療奶牛子宮內(nèi)膜炎中藥方劑—宮得健的試驗研究[D];揚州大學;2007年

4 李炳志;奶牛子宮內(nèi)膜炎菌群分析及微生態(tài)制劑對其療效觀察[D];西北農(nóng)林科技大學;2008年

5 陳現(xiàn)偉;復方中草藥制劑對奶牛子宮內(nèi)膜炎的防治效果及免疫增強功能研究[D];山東農(nóng)業(yè)大學;2007年

6 杜金梁;奶牛子宮內(nèi)膜炎治療藥物的篩選[D];河北農(nóng)業(yè)大學;2010年

7 詹靜芬;易黃湯聯(lián)合重組人干擾素治療宮頸HR-HPV感染的療效觀察及其對病毒載量的影響[D];福建中醫(yī)藥大學;2013年

，

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