發(fā)布時(shí)間：2018-03-22 21:30

  本文選題：乳腺康注射液　切入點(diǎn)：金黃色葡萄球菌　出處：《中國(guó)畜牧獸醫(yī)》2017年09期 　論文類型：期刊論文

【摘要】：試驗(yàn)旨在研究乳腺康注射液體內(nèi)外藥效。體外藥效采用牛津杯法對(duì)其進(jìn)行體外抑菌活性研究;體內(nèi)藥效采用熱板法及醋酸致小鼠扭體的鎮(zhèn)痛模型、二甲苯及雞蛋清致炎模型、2,4-二硝基酚及干酵母致大鼠發(fā)熱6種經(jīng)典藥理模型,對(duì)乳腺康注射液進(jìn)行鎮(zhèn)痛、抗炎、解熱的藥效研究。結(jié)果顯示,乳腺康注射液對(duì)大腸桿菌及金黃色葡萄球菌有較顯著的體外抑制作用,中、高劑量能極顯著提高小鼠痛閾值,極顯著減少醋酸所致扭體次數(shù)(P0.01),中劑量組能顯著降低二甲苯致小鼠耳腫脹度及雞蛋清致小鼠足跖腫脹度(P0.05),中、高劑量組對(duì)2,4-二硝基酚引起的發(fā)熱在1.5~2.0及3.0~3.5h有顯著的解熱作用(P0.05),對(duì)干酵母所引起的大鼠發(fā)熱在1.0~3.5h有顯著的解熱作用(P0.05)。結(jié)果表明,乳腺康注射液能明顯抑制大腸桿菌及金黃色葡萄球菌的活性,且具有顯著的鎮(zhèn)痛抗炎解熱作用。
[Abstract]:The aim of the experiment was to study the in vitro and in vivo pharmacodynamics of Weiankang injection, to study its antibacterial activity in vitro by Oxford cup method, and to study the analgesic model of mice writhing body induced by acetic acid and hot plate method in vivo. Six kinds of classical pharmacological models of fever induced by xylene and egg white in rats were studied on analgesic, anti-inflammatory and antipyretic effects of Dimethylbenzene and egg white. The results showed that there were 6 kinds of classical pharmacological models of fever in rats induced by xylene and egg white. The results showed that, Breast Kang injection had a significant inhibitory effect on Escherichia coli and Staphylococcus aureus in vitro, and high dose could significantly increase the pain threshold of mice. The times of writhing induced by acetic acid were significantly reduced (P 0.01). The ear swelling of mice induced by xylene and the swelling degree of feet and plantar induced by egg white were significantly decreased in medium dose group (P 0.05). The high dose group had a significant antipyretic effect on the fever induced by 2-di-4-dinitrophenol at 1.5 ~ 2.0 and 3.0 ~ 3.5h, and a significant antipyretic effect on the rat fever caused by dry yeast at 1.0 ~ 3.5h. The results showed that there was a significant antipyretic effect on the fever of rats. Weikang injection can significantly inhibit the activity of Escherichia coli and Staphylococcus aureus, and has a significant analgesic, anti-inflammatory and antipyretic effect.
【作者單位】： 成都大學(xué)藥學(xué)與生物工程學(xué)院;四川德成動(dòng)物保健品有限公司;
【基金】：四川省千人計(jì)劃(2013332)
【分類號(hào)】：S853.7
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本文編號(hào)：1650505