本文選題：中草藥方劑　切入點(diǎn)：小鼠　出處：《家畜生態(tài)學(xué)報》2017年08期 　論文類型：期刊論文

【摘要】：為研究兩種緩解馬應(yīng)激中草藥方劑的安全性,進(jìn)行了中草藥對小鼠的急性毒性試驗(yàn)。配制Ⅰ、Ⅱ號兩種中草藥方劑,各設(shè)高、中、低3個劑量試驗(yàn)組和1個空白對照組,每天灌服1次,連續(xù)灌服7d,每天觀察小鼠行為等情況,7d后,采集血液和組織臟器,測定血常規(guī)并觀察組織病理變化。結(jié)果顯示:1)Ⅰ號方劑與對照組相比,小鼠WBC、GRAN%、RBC等血液指標(biāo)顯著降低(P0.05),高劑量組肝臟臟器系數(shù)極顯著降低(P0.01),中劑量組肝臟臟器系數(shù)顯著降低(P0.05),各劑量組肝臟病理變化呈現(xiàn)由強(qiáng)到弱趨勢;2)Ⅱ號方劑與對照組相比,小鼠WBC、GRAN%等血液指標(biāo)顯著降低(P0.05),高、中劑量組肝臟的臟器系數(shù)均顯著降低(P0.05),僅高劑量組肝臟有病理變化。結(jié)論:Ⅰ號方劑對肝臟有毒副作用,作用大小呈現(xiàn)劑量依賴性;Ⅱ號方劑高劑量對肝臟有毒副作用,中、低劑量無毒副作用。
[Abstract]:In order to study the safety of two Chinese herbal remedies for relieving horse stress, the acute toxicity test of Chinese herbal medicine to mice was carried out. After 7 days of observation of the behavior of mice, blood and tissue organs were collected, blood routine was measured and pathological changes were observed. The results showed that: 1) compared with the control group. The blood indexes such as RBC of mice WBC+ GRANX and RBC were significantly decreased, the liver organ coefficient of high dose group was significantly lower than that of control group, and the liver organ coefficient of middle dose group was significantly lower than that of control group. The pathological changes of liver of each dose group showed a tendency from strong to weak) compared with the control group, the liver organ coefficient of the middle dose group was significantly lower than that of the control group, and compared with the control group, the liver pathological changes of each dose group showed a tendency from strong to weak. The liver organ coefficient of middle dose group was significantly lower than that of high dose group, only the liver of high dose group had pathological changes. Conclusion: formula I has toxic side effect on liver, and the effect is dose-dependent. The high dose of prescription 鈪，

本文編號：1614979