<正>對T細(xì)胞活化機(jī)制的研究表明,T細(xì)胞的有效活化和功能介導(dǎo)依賴于兩個信號的調(diào)節(jié)。即除通過APC遞呈MHC抗原復(fù)合物給抗原特異性T細(xì)胞提供第一信號外,還需協(xié)同刺激分子介導(dǎo)的輔助信號的協(xié)同作用[1]。如果協(xié)同刺激分子提供的第二信號發(fā)生異常,將會導(dǎo)致T細(xì)胞的程序性凋亡或者異常激活從而導(dǎo)致疾病的發(fā)生與發(fā)展[2]。已有研究表明,一系列正性和負(fù)性協(xié)同刺激信號共同介導(dǎo)了T細(xì)胞的活化,兩者之間的動態(tài)平衡在機(jī)體抵抗外 

【文章來源】：中國免疫學(xué)雜志. 2014,30(07)北大核心CSCD

【文章頁數(shù)】：7 頁

【文章目錄】：
1 PD-1/PD-L的結(jié)構(gòu)特征及生物學(xué)功能
    1.1 PD-1/PD-L的結(jié)構(gòu)特征
    1.2 PD-1/PD-L的生物學(xué)功能
        1.2.1 PD-1和PD-L的表達(dá)譜
        1.2.2 PD-1/PD-L對免疫細(xì)胞的調(diào)節(jié)作用
2 PD-1/PD-L與病毒感染
    2.1 PD-1/PD-L與AIDS
    2.2 PD-1/PD-L與慢性乙型肝炎
    2.3 PD-1/PD-L與慢性丙型肝炎
3 PD-1/PD-L與細(xì)菌感染
4 PD-1/PD-L與寄生蟲感染
5 展望與小結(jié)


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期刊論文
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[2]Natural course of chronic hepatitis B is characterized by changing patterns of programmed death type-1 of CD8-positive T cells[J]. Xue-Song Liang,Chen-Zhong Li,Mo-Bin Wan,Department of Infectious Diseases,Changhai Hospital,Second Military Medical University,Shanghai 200433,China Ying Zhou,Department of Biochemistry and Molecular Biology, Second Military Medical University,Shanghai 200433,China.  World Journal of Gastroenterology. 2010(05)
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[5]HBV感染患者外周血T細(xì)胞PD-1基因表達(dá)水平的變化與意義[J]. 彭國平,孫雯,孫箴,朱嘉珺,李淑萍,陳智.  浙江大學(xué)學(xué)報(醫(yī)學(xué)版). 2007(06)



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