H5N1亞型禽流感防疫中應(yīng)用生物信息學(xué)研究免疫方案的探討
發(fā)布時(shí)間：2019-06-29 14:36
【摘要】： 在科研面臨海量數(shù)據(jù)的年代,生物信息學(xué)作為一門新興的綜合性學(xué)科應(yīng)運(yùn)而生。95年美國人類基因組計(jì)劃第一個(gè)五年總結(jié)報(bào)告中提出生物信息學(xué)的概念,即包含生物信息的獲取、處理、貯存、分發(fā)、分析和解釋的所有方面的一門學(xué)科,它綜合運(yùn)用數(shù)學(xué)、計(jì)算機(jī)科學(xué)和生物學(xué)的各種工具進(jìn)行研究,目的在于了解大量的生物學(xué)意義。簡單說來,生物信息學(xué)是在生物科學(xué)的研究中,以計(jì)算機(jī)為工具對基因組信息進(jìn)行存儲、檢索和分析的科學(xué)。 人禽流行性感冒是由甲型禽流感病毒某些亞型中的一些毒株引起的急性呼吸道傳染病。早在1981年,美國即有禽流感病毒H7N7感染人類引起結(jié)膜炎的報(bào)道。禽流感病毒是一種流感A,分子型以H5N1來命名。字母代表紅血球凝聚素(H)和神經(jīng)氨酸苷酶(N),這是兩種可引起免疫反應(yīng)的化學(xué)組分。盡管目前人禽流感只是在局部地區(qū)出現(xiàn),但是,考慮到人類對禽流感病毒普遍缺乏免疫力、人類感染H5N1型禽流感病毒后的高病死率以及可能出現(xiàn)的病毒變異等,世界衛(wèi)生組織(WHO)認(rèn)為該疾病可能是對人類存在潛在威脅最大的疾病之一。 禽流感病毒感染方式非常復(fù)雜,這也給禽流感的防疫及治療工作造成了很大的困難。目前,借助生物信息學(xué)綜合臨床數(shù)據(jù)的方式進(jìn)行H5N1型禽流感防疫工作備受關(guān)注。本課題通過對計(jì)算機(jī)信息檢索的生物信息學(xué)與禽流感相關(guān)臨床數(shù)據(jù)進(jìn)行結(jié)合,設(shè)想了一系列針對性的實(shí)驗(yàn)探討。
[Abstract]:In the era of massive data in scientific research, bioinformatics came into being as a new comprehensive subject. In the first five-year summary report of the American Human Genome Project in 1995, the concept of bioinformatics was put forward, that is, a subject that includes all aspects of the acquisition, processing, storage, distribution, analysis and interpretation of biological information, which uses various tools of mathematics, computer science and biology to carry out research. The aim is to understand a great deal of biological significance. To put it simply, bioinformatics is a science that uses computer as a tool to store, retrieve and analyze genome information in the research of biological science. Human avian influenza is an acute respiratory infectious disease caused by some strains of avian influenza A virus. As early as 1981, avian influenza virus H7N7 infection in humans caused conjunctivitis was reported in the United States. Avian influenza virus is a kind of influenza A, the molecular type is named after H5N1. Letters represent red blood cell coagulant (H) and neuraminidase (N), two chemical components that can cause immune response. Although human avian influenza only appears in some areas at present, considering that human beings generally lack immunity to avian influenza virus, the high mortality rate after human infection with H5N1 avian influenza virus and possible virus variation, the World Health Organization (WHO) believes that the disease may be one of the most potentially threatening diseases to human beings. The infection mode of avian influenza virus is very complex, which also causes great difficulties to the prevention and treatment of avian influenza. At present, the epidemic prevention of H5N1 avian influenza with the help of bioinformatics comprehensive clinical data has attracted much attention. In this paper, a series of targeted experimental discussions are conceived by combining the clinical data of bioinformatics and avian influenza in computer information retrieval.
【學(xué)位授予單位】：華中科技大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2007
【分類號】：R392
本文編號：2507894
[Abstract]:In the era of massive data in scientific research, bioinformatics came into being as a new comprehensive subject. In the first five-year summary report of the American Human Genome Project in 1995, the concept of bioinformatics was put forward, that is, a subject that includes all aspects of the acquisition, processing, storage, distribution, analysis and interpretation of biological information, which uses various tools of mathematics, computer science and biology to carry out research. The aim is to understand a great deal of biological significance. To put it simply, bioinformatics is a science that uses computer as a tool to store, retrieve and analyze genome information in the research of biological science. Human avian influenza is an acute respiratory infectious disease caused by some strains of avian influenza A virus. As early as 1981, avian influenza virus H7N7 infection in humans caused conjunctivitis was reported in the United States. Avian influenza virus is a kind of influenza A, the molecular type is named after H5N1. Letters represent red blood cell coagulant (H) and neuraminidase (N), two chemical components that can cause immune response. Although human avian influenza only appears in some areas at present, considering that human beings generally lack immunity to avian influenza virus, the high mortality rate after human infection with H5N1 avian influenza virus and possible virus variation, the World Health Organization (WHO) believes that the disease may be one of the most potentially threatening diseases to human beings. The infection mode of avian influenza virus is very complex, which also causes great difficulties to the prevention and treatment of avian influenza. At present, the epidemic prevention of H5N1 avian influenza with the help of bioinformatics comprehensive clinical data has attracted much attention. In this paper, a series of targeted experimental discussions are conceived by combining the clinical data of bioinformatics and avian influenza in computer information retrieval.
【學(xué)位授予單位】：華中科技大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2007
【分類號】：R392
【引證文獻(xiàn)】
相關(guān)碩士學(xué)位論文 前1條
1 王艷君;腸球菌中α-L-鼠李糖苷酶的分離純化及酶學(xué)性質(zhì)研究[D];山東輕工業(yè)學(xué)院;2011年
，本文編號：2507894
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