【摘要】：人體各系統(tǒng)的生理活動均具有明顯的節(jié)律現(xiàn)象,從分子生化現(xiàn)象、組織器官的生理活動、直至個體的心理行為幾乎都存在著不同頻率的周期性波動。依照節(jié)律的周期長短可將之分為三種類型:1、近日節(jié)律(Circadian Rhythm, 或稱晝夜節(jié)律, Diurnal Rhythm),節(jié)律周期接近24 小時,一般為20-28 小時;2、超日節(jié)律(Ultradian Rhythm),節(jié)律周期明顯短于24 小時,一般短于20 小時;3、亞日節(jié)律(Infradian Rhythm),節(jié)律周期顯著長于24小時,一般長于28 小時。在人類最為常見且研究最多的是近日節(jié)律,心血管系統(tǒng)的多數(shù)生理與病理現(xiàn)象均屬此類。近年研究發(fā)現(xiàn),人體血壓呈現(xiàn)為典型的近日節(jié)律特征,并且在高血壓患者中,血壓的晝夜節(jié)律特征具有重要臨床意義。因此,充分認識血壓的時間生物學(xué)特性、深入探討血壓生物節(jié)律的調(diào)節(jié)機制對于更好的防治高血壓病具有重要意義。 血壓水平的調(diào)節(jié)是一個非常復(fù)雜的過程。在這個過程中,腎素-血管緊張素-醛固酮系統(tǒng)(RAAS)、兒茶酚胺、血管內(nèi)皮源性活性物質(zhì)等起著至關(guān)重要的作用,上述血管活性物質(zhì)的水平或活性變化將對血壓水平產(chǎn)生顯著影響。因此,深入探討血管活性物質(zhì)的晝夜波動特征對于進一步了解血壓近日節(jié)律的調(diào)控及其機制具有重要意義。此前,國外部分學(xué)者曾對腎素(Ren)、血管緊張素II (AngII)、醛固酮(Ald)、腎上腺素(E)與去甲腎上腺素(NE)、內(nèi)皮素(ET)、一氧化氮(NO)等物質(zhì)的血漿水平或活性進行了初步研究,證實上述物質(zhì)的血濃度或血漿活性存在典型的晝夜節(jié)律現(xiàn)象。但這些研究多數(shù)僅限于血循環(huán)水平。上述物質(zhì)的組織分布以及分子水平的表達是否存在近日節(jié)律尚不清楚,且血管活性物質(zhì)的晝夜波動與血壓晝夜節(jié)律之間的關(guān)系亦有待深入探討。 生命體各種節(jié)律現(xiàn)象是在漫長的生物進化過程中逐漸產(chǎn)生并作為一種遺傳信息保持下來的。自地球上出現(xiàn)生命伊始,伴隨著地球的公轉(zhuǎn)與自轉(zhuǎn),生命體經(jīng)歷著周而復(fù)始的溫度(一年四季的溫度差異與晝夜溫度差異)與亮度(主要是晝夜之間的明暗交替)的周期性變化。為了更好的適應(yīng)生存環(huán)境,生命體內(nèi)的各種生理、生化或代謝過程也不斷發(fā)生著相應(yīng)的變化,
[Abstract]:The physiological activities of human body have obvious rhythmic phenomena, from molecular biochemical phenomena, physiological activities of tissues and organs, to the psychological behavior of individuals, there are almost periodic fluctuations of different frequencies. According to the period of rhythm, it can be divided into three types: 1, circadian (Circadian Rhythm, or circadian rhythm, Diurnal Rhythm), rhythm cycle is close to 24 hours, generally 20-28 hours; (2) the period of (Ultradian Rhythm), rhythm is shorter than 24 hours, generally shorter than 20 hours, and 3, the rhythm period of (Infradian Rhythm), is longer than 24 hours and generally longer than 28 hours. Circadian rhythms are the most common and studied in humans, and most physiological and pathological phenomena in the cardiovascular system fall into this category. In recent years, it has been found that human blood pressure presents a typical circadian rhythm, and the circadian rhythm of blood pressure has important clinical significance in hypertensive patients. Therefore, it is of great significance to fully understand the chronobiological characteristics of blood pressure and probe into the regulation mechanism of biological rhythm of blood pressure for better prevention and treatment of hypertension. Regulation of blood pressure levels is a very complex process. In this process, the renin-angiotensin-aldosterone system (RAAS), catecholamine, vascular endothelial-derived active substances and so on play an important role. Changes in the level or activity of these vasoactive substances will have a significant effect on blood pressure levels. Therefore, it is important to study the diurnal fluctuation of vasoactive substances in order to further understand the regulation and mechanism of blood pressure circadian rhythm. Prior to this, some foreign scholars had studied renin (Ren), angiotensin II (AngII), aldosterone, (Ald), adrenaline (E), and noradrenaline (NE), endothelin (ET), The plasma level or activity of nitric oxide (NO) and other substances were preliminarily studied. It was confirmed that there was a typical circadian rhythm in the plasma concentration or plasma activity of these substances. But most of these studies are limited to blood circulation levels. It is not clear whether there is a circadian rhythm in the tissue distribution and molecular level of these substances, and the relationship between the circadian fluctuation of vasoactive substances and the circadian rhythm of blood pressure needs to be further explored. Various rhythms of life are gradually produced during the long evolutionary process and maintained as a genetic information. Since the beginning of life on the earth, with the rotation and rotation of the earth, Life goes through periodic changes in temperature (temperature difference and diurnal temperature difference throughout the year) and brightness (light and dark alternation between day and night). In order to better adapt to the living environment, various physiological, biochemical or metabolic processes in the body of life are constantly changing accordingly.
【學(xué)位授予單位】：河北醫(yī)科大學(xué)
【學(xué)位級別】：博士
【學(xué)位授予年份】：2005
【分類號】：R33

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