【摘要】：骨髓間充質(zhì)干細胞(Mesenchymal stem cells,MSCs)是一類具有向中胚層、外胚層及內(nèi)胚層多種組織細胞分化能力的原始細胞;在體外、體內(nèi)均可定向分化為成骨細胞和成軟骨細胞;作為這些骨生成細胞的來源細胞,MSCs是骨組織再生的細胞學基礎(chǔ)。基于其多向分化潛能,骨髓MSCs目前已成為組織工程、細胞工程領(lǐng)域最重要的種子細胞,其潛在應(yīng)用價值越來越受到人們重視;有關(guān)骨髓MSCs的基礎(chǔ)和臨床應(yīng)用研究逐漸成為國際上干細胞領(lǐng)域研究的重點。 骨組織的再生和改建涉及復(fù)雜的力學刺激,其中機械力學刺激是其中非常重要的一環(huán);尤其在牽張成骨(distraction osteogenesis,DO)的骨再生過程中,適宜的機械張應(yīng)力刺激則顯得尤為重要。在牽張成骨中,新骨形成涉及多種細胞參與,這包括未分化的間充質(zhì)干細胞(MSCs)、成骨細胞(OB)及其前體細胞、成纖維細胞、破骨細胞、內(nèi)皮細胞等;其中MSCs在機械張應(yīng)力下向牽張區(qū)募集、增殖、及成骨細胞向分化,是新骨形成的細胞學基礎(chǔ)。機械力學刺激是細胞在生物進化過程中受到的最基本的生物刺激之一。適當?shù)臋C械力學刺激可以促進細胞的生長、分化和功能的維持,但過度或持續(xù)時間過長的力學刺激又會對細胞的結(jié)構(gòu)和功能造成損害;因此細胞是如何感受力學刺激信號并將其轉(zhuǎn)化為生物化學信號的,其中涉及哪些信號通路以及相關(guān)基因的表達,一直是各國學者不斷探索的前沿課題。近年來,國內(nèi)外學者
[Abstract]:Bone marrow mesenchymal stem cell (Mesenchymal stem cells,MSCs) is a kind of progenitor cells with the ability to differentiate into mesoderm, ectoderm and endoderm, which can be differentiated into osteoblasts and chondroblasts in vitro. As the source of these osteogenic cells, MSCs is the cytological basis for bone regeneration. Because of its multidirectional differentiation potential, bone marrow MSCs has become the most important seed cells in tissue engineering and cell engineering, and its potential application value has been paid more and more attention. The basic and clinical application of bone marrow MSCs has gradually become the focus of stem cell research in the world. The regeneration and remodeling of bone tissue involves complex mechanical stimulation, in which mechanical stimulation is a very important part, especially in the process of bone regeneration of distraction osteogenesis (distraction osteogenesis,DO). In distraction osteogenesis, new bone formation involves a variety of cell involvement, including undifferentiated mesenchymal stem cell (MSCs), osteoblast (OB) and its precursors, fibroblasts, osteoclasts, endothelial cells and so on. The recruitment, proliferation and differentiation of osteoblasts from MSCs to the distraction zone under mechanical tensile stress are the cytological basis of new bone formation. Mechanical stimulation is one of the most basic biological stimuli to cells during biological evolution. Proper mechanical stimulation can promote cell growth, differentiation and function maintenance, but excessive or prolonged mechanical stimulation will damage cell structure and function. Therefore, how cells perceive mechanical stimuli and convert them into biochemical signals, which signaling pathways and related genes are involved, has been a frontier topic for researchers all over the world. In recent years, scholars at home and abroad
【學位授予單位】：四川大學
【學位級別】：博士
【學位授予年份】：2005
【分類號】：R329.2

【引證文獻】

相關(guān)期刊論文 前1條

1 黎潤光;邵景范;魏明發(fā);;機械力學對體外骨髓間充質(zhì)干細胞的影響[J];中國組織工程研究與臨床康復(fù);2007年03期

相關(guān)博士學位論文 前1條

1 楊麗;OP模鼠MSCs生物學特性及藥物對大鼠MSCs骨向分化的干預(yù)研究[D];暨南大學;2007年

相關(guān)碩士學位論文 前2條

1 龔理;柚皮苷對骨質(zhì)疏松模型大鼠MSCs增殖、骨向分化及凋亡影響的實驗研究[D];暨南大學;2006年

2 鄭曉黎;蛇床子素對大鼠骨髓間充質(zhì)干細胞增殖和骨向分化的影響[D];暨南大學;2008年

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本文編號：2415045