【摘要】：脊髓背角淺層,不僅是接受無髓和薄髓初級傳入纖維傳遞的外周傷害性信息的初級門戶,也是來自中樞內源性鎮(zhèn)痛系統(tǒng)投射纖維傳遞的痛抑制信息的主要終止部位。阿片類物質在脊髓背角淺層具有調控外周傷害性信息向中樞傳遞的重要作用。脊髓背角淺層內有密集的內嗎啡肽(EMs)樣陽性纖維和終末,EMs是μ阿片受體(MOR)的內源性高選擇性配體。EMs樣陽性結構在脊髓背角內的分布與MOR的分布互相匹配。EMs分為EM-1和EM-2。在嚙齒動物中,EM-1主要存在于脊髓以上的腦結構,而EM-2主要分布于脊髓水平。脊髓背角淺層的EM-2樣陽性結構主要來源于初級傳入纖維和終末。鞘內注射EMs比將EMs注射到腦室系統(tǒng)內能發(fā)揮更強烈的鎮(zhèn)痛作用。電生理研究的結果顯示鞘內注射EM-2能選擇性地抑制由刺激C纖維所引起的痛反應。脊髓背根神經(jīng)節(jié)(DRG)內有EM-2樣陽性神經(jīng)元胞體。EM-2與P物質(SP)在大量DRG神經(jīng)元內共存。以上結果提示EMs在傷害性信息的調控中可能發(fā)揮了重要作用。為了進一步闡明其鎮(zhèn)痛機制,本研究采用行為藥理學方法觀察了EMs
[Abstract]:The superficial layer of spinal dorsal horn is not only the primary portal of peripheral nociceptive information transmitted by unmyelinated and thin medullary primary afferent fibers, but also the main terminating point of pain suppression information transmitted by the projection fibers of central endogenous analgesic system. Opioids play an important role in regulating the transmission of peripheral nociceptive information to the central nervous system in the superficial layer of the dorsal horn of the spinal cord. There were dense endomorphine-like (EMs) positive fibers and terminals in the superficial layer of the dorsal horn of the spinal cord. EMs is the endogenous high selective ligand of 渭 opioid receptor (MOR). The distribution of EMs like positive structure in the dorsal horn of spinal cord matches the distribution of MOR. EMs is divided into EM-1 and EM-2.. In rodents, EM-1 mainly exists in the brain structure above the spinal cord, while EM-2 is mainly distributed at the spinal cord level. The EM-2-like positive structures in the superficial layer of the dorsal horn of the spinal cord are mainly derived from primary afferent fibers and terminals. Intrathecal injection of EMs has a stronger analgesic effect than intrathecal injection of EMs into the ventricular system. The results of electrophysiological studies showed that intrathecal injection of EM-2 could selectively inhibit the pain response induced by stimulation of C fibers. There were EM-2 like positive neurons in (DRG) of dorsal root ganglion of spinal cord. EM-2 and substance P (SP) co-existed in a large number of DRG neurons. These results suggest that EMs may play an important role in the regulation of nociceptive information. In order to further elucidate the analgesic mechanism, EMs was observed by behavioral pharmacology.
【學位授予單位】：第四軍醫(yī)大學
【學位級別】：碩士
【學位授予年份】：2005
【分類號】：R33

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相關期刊論文 前1條

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本文編號：2402971