【摘要】：結(jié)核病(Tuberculosis,TB)是由結(jié)核分枝桿菌(Mycobacterium tuberculosis,MTB)引起的以呼吸道傳播為主的慢性傳染性疾病。近年來(lái),由于卡介苗(BCG)保護(hù)性的不完善、MTB耐藥性的產(chǎn)生、艾滋病的流行、世界人口的劇增、全球性旅游業(yè)的發(fā)展以及吸毒、酗酒、貧窮等原因,TB的發(fā)病率呈日益嚴(yán)重的回升趨勢(shì),再次成為危害人類(lèi)健康的世界性疾病。WHO指出,全世界現(xiàn)有TB患者2000萬(wàn),每年新發(fā)生約900萬(wàn)例,每年死亡約300萬(wàn)例。WHO預(yù)測(cè),在未來(lái)的10年中,全球?qū)⒂谐^(guò)3億人感染MTB,9000萬(wàn)人發(fā)病,3000萬(wàn)人死于TB。因此,積極研究TB的致病及免疫機(jī)制,研制更為有效的診斷、預(yù)防和治療MTB感染的新技術(shù)、新方法、新疫苗等具有重要意義。 藤黃微球菌(Micrococcus luteus)中的促進(jìn)復(fù)活因子(resuscitation-promoting factor,Rpf)是被發(fā)現(xiàn)的第一種細(xì)菌的細(xì)胞因子,它具有促進(jìn)休眠菌的復(fù)蘇以及促進(jìn)細(xì)菌快速生長(zhǎng)的作用。序列對(duì)比分析發(fā)現(xiàn),在其他的一些革蘭陽(yáng)性細(xì)菌如MTB、麻風(fēng)分枝桿菌、藍(lán)色鏈霉菌、谷氨酸棒桿菌等中也存在著30多個(gè)與Rpf同源的蛋白,其中在MTB中就有5個(gè)Rpf樣蛋白,分別為Rv1884c、Rv2389c、Rv2450、Rv1009和Rv0867,推測(cè)這些蛋白也可能具有促進(jìn)MTB快速生長(zhǎng)的作用。此外,
[Abstract]:Tuberculosis (Tuberculosis,TB) is a chronic infectious disease mainly caused by mycobacterium tuberculosis (Mycobacterium tuberculosis,MTB). In recent years, due to the imperfect protection of BCG (BCG), the emergence of drug resistance to MTB, the prevalence of AIDS, the rapid growth of the world population, the development of global tourism, and the causes of drug abuse, alcohol abuse, poverty, and so on, The incidence of TB is on the rise and is once again a worldwide disease that endangers human health. WHO points out that there are 20 million TB patients in the world, about 9 million new cases annually, and about 3 million deaths per year. WHO predicts that, In the next 10 years, more than 300 million people worldwide will be infected with MTB, and 30 million will die of TB. Therefore, it is of great significance to study the pathogenesis and immune mechanism of TB, to develop a more effective diagnosis, prevention and treatment of MTB infection of new technology, new methods, new vaccines and so on. Resuscitation-promoting factor,Rpf is the first bacterial cytokine found in (Micrococcus luteus) of Micrococcus luteus. It can promote the recovery of dormancy bacteria and the rapid growth of bacteria. Sequence analysis showed that there were more than 30 Rpf homologous proteins in other Gram-positive bacteria such as Mycobacterium MTB, Streptomyces blue and Corynebacterium glutamate, among which 5 Rpf like proteins were found in MTB. Rv1884c,Rv2389c,Rv2450,Rv1009 and Rv0867, suggest that these proteins may also promote the rapid growth of MTB. In addition,
【學(xué)位授予單位】：第四軍醫(yī)大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2005
【分類(lèi)號(hào)】：R392

【引證文獻(xiàn)】

相關(guān)博士學(xué)位論文 前1條

1 樊愛(ài)琳;Rpf蛋白結(jié)構(gòu)域的生物學(xué)及免疫學(xué)特性的初步研究[D];第四軍醫(yī)大學(xué);2008年

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本文編號(hào)：2299579