【摘要】：目的:探索高原低氧應(yīng)激環(huán)境對大鼠糖脂代謝的影響。方法:將大鼠隨機(jī)分為對照組和低壓缺氧應(yīng)激組,缺氧組大鼠置模擬海拔6 000m低壓艙內(nèi)48h×3次,實驗結(jié)束后,缺氧組從低壓氧艙中取出后立即斷頭處死,測定血糖,胰島素,采用穩(wěn)態(tài)模型HOMAβ評估胰島β細(xì)胞功能,測定血脂(TC、TG、LDL-C、HDL-C),稱量臟器重量,測定肝、肌糖原含量。結(jié)果:相比較正常組,Hypoxia組大鼠血糖值稍有降低,但胰島素水平顯著升高(P0.05)。Hypoxia組大鼠的HOMAβ高于正常對照組。臟器重量結(jié)果顯示,Hypoxia組大鼠的腎臟重量顯著降低(P0.05),脾臟、肝臟重量顯著升高(P0.01,P0.05),腎上腺重量有下降趨勢。與正常對照組相比,Hypoxia組大鼠TC含量顯著增高(P0.01);Hypoxia組大鼠肝糖原顯著升高(P0.05),而肌糖原顯著降低(P0.01);Hypoxia組大鼠TRH、TSH、T3具有下降趨勢,僅TSH具有統(tǒng)計學(xué)意義(P0.01),而T4顯著升高(P0.05)。結(jié)論:高原低氧應(yīng)激條件下,大鼠機(jī)體呈現(xiàn)血糖降低,胰島功能增強(qiáng),肝糖原儲備增加,肌糖原儲備減少,糖脂代謝紊亂。
[Abstract]:Objective: to explore the effect of high altitude hypoxia stress environment on glucose and lipid metabolism in rats. Methods: rats were randomly divided into control group and hypobaric stress group. Rats in hypoxia group were placed in a hypobaric chamber at a simulated altitude of 6 000 m for 48 h 脳 3 times. After the experiment, the rats in hypoxia group were taken out of hypobaric oxygen chamber and killed immediately, blood glucose and insulin were measured. The steady-state model HOMA 尾 was used to evaluate the function of islet 尾 cells, to measure serum lipids, to weigh organ weight, and to determine the content of glycogen in liver and muscle. Results: compared with the normal group, the blood glucose level in the Hypoxia group was slightly lower, but the insulin level was significantly increased (P0.05). The HOMA 尾 in the Hypoxia group was higher than that in the normal control group. The results of organ weight showed that the weight of kidney decreased significantly (P0.05), the weight of spleen and liver increased significantly (P0.01P05), and the weight of adrenal gland decreased in the group of Hypoxia. Compared with the normal control group, the TC content in the Hypoxia group was significantly higher (P0.01) and the hepatic glycogen level in the Hypoxia group was significantly higher (P0.05), while the muscle glycogen significantly decreased (P0.01) in the Hypoxia group, only TSH had statistical significance (P0.01), while T4 significantly increased (P0.05). Conclusion: under the condition of high altitude hypoxia stress, the blood glucose decreased, the islet function increased, the hepatic glycogen reserve increased, the muscle glycogen reserve decreased, and the metabolism of glucose and lipid was disturbed.
【作者單位】： 蘭州軍區(qū)蘭州總醫(yī)院內(nèi)分泌科;蘭州軍區(qū)蘭州總醫(yī)院高原環(huán)境損傷防治重點實驗室;
【基金】：國家自然科學(xué)基金資助項目(81173620,30772773)
【分類號】：R339.5

【參考文獻(xiàn)】

相關(guān)期刊論文 前3條

1 黃緘,黃慶愿,高鈺琪,陳健,范有明,廖衛(wèi)公;缺氧習(xí)服大鼠骨骼肌葡萄糖轉(zhuǎn)運(yùn)體特點的研究[J];第三軍醫(yī)大學(xué)學(xué)報;2004年18期

2 黃緘,范有明,高鈺琪,黃慶愿,羅德成,孫秉庸;慢性缺氧對大鼠骨骼肌胰島素受體的影響及其在增強(qiáng)葡萄糖攝取能力中的作用[J];第三軍醫(yī)大學(xué)學(xué)報;2005年01期

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本文編號：2192442