【摘要】：1.我國(guó)中部河南省和湖北省有償供血人群中HIV-1的分子流行病學(xué)研究 自從HIV-1傳入我國(guó)以來(lái)在我國(guó)的傳播速度速度日益增長(zhǎng),范圍越來(lái)越廣。在河南和湖北等省許多地區(qū),通過(guò)有償供血感染HIV-1的人群引起了社會(huì)各界的廣泛關(guān)注。為了研究河南和湖北省有償供血人群中流行的HIV-1的遺傳背景,我們對(duì)在2000年-2004年收集的標(biāo)本進(jìn)行了分子流行病學(xué)的分析。在收集的標(biāo)本中69份來(lái)自河南和湖北省不同地區(qū)的有償供血人員。通過(guò)對(duì)HIV-1gag的系統(tǒng)進(jìn)化分析,我們發(fā)現(xiàn)在這兩省有償供血人群中流行的HIV-1遺傳距離非常接近,河南省內(nèi)流行的為3.8±0.8,湖北的為4.2±0.9,小于云南省的5.6,并且都與以前在云南省發(fā)現(xiàn)的YN.RIA2毒株相近,都為B'亞型病毒。對(duì)病毒的env以及pol片段的分析也顯示了同樣的結(jié)果。而且在進(jìn)化樹(shù)上我們也沒(méi)有看到病毒根據(jù)不同地區(qū)聚集在進(jìn)化樹(shù)不同分枝的現(xiàn)象。我們的結(jié)果顯示,B~'亞型病毒是河南和湖北省有償供血人群中流行的主要病毒株,其來(lái)源相同,很可能是由云南傳入,而且傳入河南和湖北省的時(shí)間可能要早于07_BC和08_BC重組型病毒在云南德宏地區(qū)形成的時(shí)間。 與此同時(shí)我們也對(duì)北京、新疆等地流行的HIV-1做了分析。與在有償供血人群中流行的HIV-1不同,北京通過(guò)性傳播感染的HIV-1主要是歐美B亞型病毒,新疆吸毒人群中流行的主要是07_BC重組型病誨。
[Abstract]:1. Molecular Epidemiology of HIV-1 among paid Blood donors in Henan Province and Hubei Province in Central China the spread of HIV-1 in China has been increasing since it was introduced into China. The scope is getting wider and wider. In many areas of Henan and Hubei provinces, people infected with HIV-1 through paid blood supply have attracted wide attention from all walks of life. In order to study the genetic background of HIV-1 in the paid blood donors of Henan and Hubei Province, we analyzed the molecular epidemiology of the samples collected from 2000 to 2004. Of the collected specimens, 69 were paid blood donors from different areas of Henan and Hubei provinces. Based on the phylogenetic analysis of HIV-1 gag, we find that the genetic distance of HIV-1 is very close among the paid blood donors in these two provinces. The prevalence of YN.RIA2 in Henan Province was 3.8 鹵0.8, while that in Hubei was 4.2 鹵0.9, which was smaller than that in Yunnan Province (5.6%), and were similar to the YN.RIA2 strains previously found in Yunnan Province, and were all B'subtype viruses. Analysis of env and pol fragments of the virus showed the same result. Moreover, we do not see the virus clustered in different branches of the evolutionary tree according to different regions in the evolutionary tree. Our results show that the virus is the main virus strain in the paid blood supply population in Henan and Hubei Province, and its origin is the same, which is probably introduced from Yunnan. Moreover, the time of transmission to Henan and Hubei Province may be earlier than that of 07C and 08SZ recombined virus in Dehong region of Yunnan Province. At the same time, we also analyzed the prevalence of HIV-1 in Beijing, Xinjiang and other places. Different from HIV-1 which is prevalent in paid blood supply population, HIV-1 infected by sexual transmission in Beijing is mainly subtype B virus in Europe and America, and in drug users in Xinjiang, it is mainly the 07BC recombinant disease.
【學(xué)位授予單位】：武漢大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2005
【分類號(hào)】：R373

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 潘品良,曾常紅,范秀娟,姚均,邢輝,馮毅,邵一鳴;人類免疫缺陷病毒膜蛋白基因(env)F亞型毒株在中國(guó)的首例發(fā)現(xiàn)[J];病毒學(xué)報(bào);1999年02期

2 白旭華,管永軍,張遠(yuǎn)志,邵一鳴,王冬莉,蘇玲,劉小良,趙全壁,杜大衛(wèi),ＪｏｓｅｆＫｏｓｔｌｅｒ,ＨａｎｓＷｏｌｆ;新疆烏魯木齊HIV-1流行毒株膜蛋白基因C2-V3區(qū)序列測(cè)定和亞型分析[J];病毒學(xué)報(bào);1997年04期

3 邵一鳴，管永軍，，趙全壁，曾毅，張家鵬，張勇，段一娟，楊貴林;1995年云南瑞麗HIV1毒株的基因變異和分析[J];病毒學(xué)報(bào);1996年01期

4 黎志東,徐志凱,張亮,趙巧云,劉克輝;陜西省HIV-1分子流行病學(xué)研究[J];中國(guó)皮膚性病學(xué)雜志;2003年01期

5 賈成梅,羊海濤,徐曉琴,李雷,劉光中,邢輝,邵一鳴;江蘇省艾滋病流行特征及流行趨勢(shì)分析[J];中國(guó)艾滋病性病;2002年01期

6 姚均,何忠平,趙紅心,李興旺,馮鑫,徐克沂,張福杰;北京市同性戀HIV-1感染者的包膜基因C2-V3區(qū)序列測(cè)定和亞型分析[J];中國(guó)艾滋病性病;2002年03期

7 邢輝,潘品良,蘇玲,范秀娟,馮毅,強(qiáng)來(lái)英,邵一鳴;1996～1998年中國(guó)流行的E亞型艾滋病病毒1型毒株的分子流行病學(xué)研究[J];中國(guó)艾滋病性病;2002年04期

8 陳恩富,楊介者,孫頌文,許鋒華;浙江省2000～2001年艾滋病病毒/艾滋病流行病學(xué)分析[J];中國(guó)艾滋病性病;2002年05期

9 馮鐵建!518020,邵一鳴,李良成!518020,蘇玲,張順祥!518020,趙全壁,袁建中;深圳市HIV-1 E亞型感染毒株的分子流行病學(xué)分析[J];中華實(shí)驗(yàn)和臨床病毒學(xué)雜志;2000年04期

10 雷世光!550001貴陽(yáng)市,孫顯光!550001貴陽(yáng)市,楊宏亞!550001貴陽(yáng)市,王丁力!550001貴陽(yáng)市,樂(lè)斌!550001貴陽(yáng)市,李豫!550001貴陽(yáng)市,邵一鳴,邢輝;貴州省HIV-1感染毒株膜蛋白基因序列測(cè)定及流行病學(xué)分析[J];中華皮膚科雜志;2000年03期

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