本文選題：ALEX_2 + armadillo��； 參考：《第四軍醫(yī)大學(xué)》2005年碩士論文

【摘要】：ALEX2基因(Arm proteins lost in epithelial cancers,X chromosome,2),屬于ALEX家族成員,除ALEX2基因外,該家族還包括ALEX1和ALEX3基因。ALEX家族基因的共同特點(diǎn)是基因均定位于染色體Xq21.33-q22.2上;蛋白序列中都含有Armadillo repeat結(jié)構(gòu);蛋白序列高度同源,在蛋白N端都具有一個疏水的跨膜區(qū)。在組織表達(dá)分布上亦有很高的一致性:RT-PCR分析表明,在正常組織中除肝臟、胸腺組織低表達(dá),外周血白細(xì)胞未見表達(dá)外均有廣泛的表達(dá);腫瘤組織中,在上皮組織來源的腫瘤組織(即癌組織)中低表達(dá)或不表達(dá),提示ALEX家族蛋白在上皮組織來源的腫瘤的發(fā)生、發(fā)展過程中可能起重要作用,與癌組織的發(fā)生、惡化有潛在的關(guān)系。 Armadillo(arm)repeat結(jié)構(gòu)首次發(fā)現(xiàn)于果蠅極性基因—armadillo,該基因在果蠅胚胎形成、維持上皮組織完整性和早期細(xì)胞極性形成中起重要作用。Arm repeat結(jié)構(gòu)的特點(diǎn)是在真核和原核生物中都
[Abstract]:ALEX2 gene (Arm proteins lost in epithelial cancersX chromosome 2 (ALEX2) belongs to the Alex family. In addition to the ALEX2 gene, the common feature of this family is that the ALEX1 and ALEX3 genes are located on chromosome Xq21.33-q22.2, and the protein sequences contain Armadillo repeat structure. The protein sequence is highly homologous and has a hydrophobic transmembrane region at the N-terminal of the protein. There was also a very high consistency in the tissue expression distribution. The results of RT-PCR analysis showed that in normal tissues, the expression was low in liver and thymus tissues, but not in peripheral white blood cells, while in tumor tissues, there was no expression in peripheral white blood cells. The low expression or non-expression of Alex family proteins in tumour tissues derived from epithelial tissues may play an important role in tumorigenesis and development of epithelial tissues, and may play an important role in carcinogenesis. The potentially related. Armadillo (arm) repeat structure was first found in Drosophila melanogaster polarity gene-armadilloillogene, which was formed in the embryo of Drosophila melanogaster. Maintaining the integrity of epithelial tissue and early cell polarity formation plays an important role. Arm repeat structure is characterized in both eukaryotes and prokaryotes.
【學(xué)位授予單位】：第四軍醫(yī)大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2005
【分類號】：R346

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1 張勇;人ALEX2基因的克隆、表達(dá)與純化及生物信息學(xué)分析[D];第四軍醫(yī)大學(xué);2005年

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本文編號：2085113