本文選題：嗅鞘細(xì)胞 + 細(xì)胞存活��； 參考：《第四軍醫(yī)大學(xué)》2006年碩士論文

【摘要】：脊髓損傷(spinal cord injury SCI)后患者生活質(zhì)量嚴(yán)重受損，，造成難以恢復(fù)的終身殘疾，后果嚴(yán)重，是醫(yī)學(xué)領(lǐng)域的難題之一。隨著SCI研究的不斷深入，人們逐漸認(rèn)識(shí)到減輕脊髓繼發(fā)性損害是促進(jìn)脊髓損傷后再生和進(jìn)一步治療的基礎(chǔ)。嗅鞘細(xì)胞(olfactory ensheathing cell OECs)因其獨(dú)特的細(xì)胞生物學(xué)特性成為了近年來(lái)脊髓損傷后移植治療的熱點(diǎn)。移植嗅鞘細(xì)胞能促進(jìn)SCI后神經(jīng)軸突的再生，但其效果不一，如何合理的進(jìn)行移植，最大程度的發(fā)揮其作用，是值得關(guān)注的研究方向。SCI后移植細(xì)胞的目的是在脊髓兩斷端之間建立引導(dǎo)、促進(jìn)神經(jīng)纖維再生的橋梁。目前常用的移植方法是在脊髓損傷區(qū)兩殘端內(nèi)植入嗅鞘細(xì)胞，而不是直接移植到兩斷端之間，其原因有：損傷區(qū)的惡劣環(huán)境不利于移植后嗅鞘細(xì)胞的存活繁殖；此外移植的嗅鞘細(xì)胞不能和兩脊髓斷端保持有效的接觸可能影響其遷移，嗅鞘細(xì)胞不能有效發(fā)揮作用。SCI后損傷區(qū)的繼發(fā)性病理變化不利于移植后嗅鞘細(xì)胞的生存，與此相關(guān)的因素眾多，譬如：
[Abstract]:After spinal cord injury (spinal cord injury sci), the quality of life of the patients is seriously damaged, resulting in a life-long disability that is difficult to recover, and the consequences are serious, which is one of the difficult problems in the medical field. With the development of sci, it is gradually recognized that reducing the secondary injury of spinal cord is the basis of promoting regeneration and further treatment after spinal cord injury. Olfactory ensheathing cells (OECs) have become the focus of transplantation treatment after spinal cord injury in recent years because of their unique cellular biological characteristics. Transplantation of olfactory ensheathing cells can promote the regeneration of axons after sci, but the effect is different. The purpose of transplantation cells after sci is to establish a bridge between the two broken ends of spinal cord and promote the regeneration of nerve fibers. At present, the commonly used transplantation method is to implant olfactory ensheathing cells into the two stumps of spinal cord injury area, instead of transplanting directly between the two broken ends. The reasons are as follows: the bad environment in the injured area is not conducive to the survival and reproduction of olfactory ensheathing cells after transplantation; In addition, the transplanted olfactory ensheathing cells could not maintain effective contact with the two spinal cord broken ends, and the olfactory ensheathing cells could not play an effective role. The secondary pathological changes in the injured area after sci were not conducive to the survival of the olfactory ensheathing cells after transplantation. There are a number of factors associated with this, such as:
【學(xué)位授予單位】：第四軍醫(yī)大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2006
【分類號(hào)】：R651.2;R329

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 孟曉梅,王春婷,游思維,劉惠玲,楊浩,焦西英,劉飛,史明,鞠躬;纖維蛋白膠包裹嗅神經(jīng)鞘細(xì)胞促進(jìn)脊髓軸突再生的實(shí)驗(yàn)研究[J];解剖學(xué)報(bào);2003年03期

2 楊浩,王春婷,程華玲,鞠躬;嗅神經(jīng)鞘細(xì)胞的培養(yǎng)純化及體外生長(zhǎng)特性[J];細(xì)胞生物學(xué)雜志;2001年01期

本文編號(hào)：2051667