本文選題：經(jīng)導管 + 主動脈瓣關(guān)閉不全��； 參考：《介入放射學雜志》2014年07期

【摘要】：目的探討通過經(jīng)導管介入的方法破壞大動物的主動脈瓣,建立急性主動脈瓣膜關(guān)閉不全模型的可行性和有效性。方法選取健康山羊8只,側(cè)開胸小切口暴露心尖,穿刺左心室心尖,建立軌道,X線引導下沿加硬導絲送入10 F輸送鞘管至主動脈瓣上,退出內(nèi)鞘。沿10 F輸送鞘管送入腰部直徑為10 mm的肌部室間隔缺損(室缺)封堵器至主動脈瓣上,回撤10 F輸送鞘管至左心室保留封堵器在主動脈瓣上�？焖倩乩胰狈舛缕髦磷笮氖乙栽斐芍鲃用}瓣膜破壞,建立急性主動脈瓣關(guān)閉不全的模型。手術(shù)后即刻主動脈瓣上造影經(jīng)胸心臟超聲確定主動脈瓣返流程度。結(jié)果 8只實驗羊即時主動脈瓣返流模型均成功建立。其中2只因主動脈瓣返流量過大致急性左心衰竭當場死亡。術(shù)后解剖肉眼觀察可見主動脈瓣葉受損。存活的6只羊經(jīng)術(shù)后主動脈瓣上造影及心臟超聲檢查證實其中5只為中量主動脈瓣返流,1只為少量返流。術(shù)后7、15 d分別有1只中等量返流實驗羊死于心力衰竭,余4只羊存活超過3個月。3個月后復查超聲提示主動脈瓣輕至中度返流。結(jié)論經(jīng)心尖途徑經(jīng)導管室缺封堵器回拉法制作大動物急性主動脈瓣返流主動脈瓣關(guān)閉不全模型可行,操作簡單、重復性好,主動脈瓣反流程度可控,效果可靠。
[Abstract]:Objective to study the feasibility and effectiveness of acute aortic valve insufficiency model by using catheter intervention to destroy aortic valve in large animals. Methods 8 healthy goats were selected. The left ventricular apex was exposed through a small incision of open chest, and the orbit was established. Under the guidance of X ray, the sheath was transferred to the aortic valve along the hard wire to transport the sheath to the aortic valve, and the sheath was withdrawn from the inner sheath. The 10 F sheathing tube was fed into the aortic valve with a lumbar diameter of 10 mm. The 10 F sheathing tube was withdrawn to the left ventricular retaining occluder on the aortic valve. The model of acute aortic insufficiency was established by rapid retraction of ventricular occluder to the left ventricle to cause aortic valve damage. The degree of aortic valve regurgitation was determined by transthoracic echocardiography immediately after operation. Results the model of immediate aortic regurgitation was established successfully in 8 experimental sheep. Two of them died on the spot due to aortic regurgitation flow, largely acute left ventricular failure. Postoperative anatomical observation showed aortic valve damage. Among the 6 surviving sheep, 5 were confirmed as moderate aortic regurgitation and 1 as a small amount of regurgitation by superior aortic valve angiography and echocardiography. One moderate regurgitation experiment died of heart failure on the 7th and 15th day after operation, and the remaining 4 sheep survived for more than 3 months. After 3 months, reexamination of ultrasound revealed mild to moderate aortic valve regurgitation. Conclusion it is feasible to establish acute aortic regurgitation aortic valve insufficiency model by transcatheter closure with transcatheter ventricular septal defect occluder via apical approach, simple operation, good repeatability, controllable degree of aortic regurgitation and reliable effect.
【作者單位】： 復旦大學附屬中山醫(yī)院心血管內(nèi)科;第二軍醫(yī)大學長海醫(yī)院心血管內(nèi)科;第二軍醫(yī)大學長海醫(yī)院心胸外科;
【基金】：中國博士后科學基金面上資助(2014M551330)
【分類號】：R-332;R541

【相似文獻】

相關(guān)期刊論文 前10條

1 李玉晶;仇新全;李健英;呂律;;齲齒的動物模型及其應用[J];實驗動物科學與管理;1986年03期

2 李杰;;我國不同流行區(qū)周期型馬來絲蟲動物模型的建立[J];大連醫(yī)科大學學報;1989年03期

3 孫揚;朱仕欽;;實驗性呼吸窘迫綜合征動物模型及藥物治療[J];中國危重病急救醫(yī)學;1991年03期

4 于文慧;建立慢性腎衰動物模型方法研究的進展[J];天津醫(yī)藥;1994年11期

5 郭成浩,張輝,金毅,孫波,王凡,李廣生;不同血鈣水平大鼠動物模型的建立[J];動物學雜志;1999年02期

6 丁正明,宮斌,莫啟忠;老年癡呆動物模型研究進展[J];浙江中西醫(yī)結(jié)合雜志;2000年10期

7 趙宗江,張新雪,牛建昭;中醫(yī)證候動物模型存在的問題與對策[J];中國中醫(yī)藥信息雜志;2002年06期

8 任明,高秀梅;動物實驗在中醫(yī)藥研究中的局限和展望[J];遼寧中醫(yī)雜志;2004年10期

9 程吉勇,楊華,劉健;動脈瘤動物模型的建立[J];國外醫(yī)學.腦血管疾病分冊;2005年03期

10 雷作熹,羅仁,董曉蕾,鐘先陽;STZ誘導糖尿病腎病大鼠模型的建立[J];中國實驗動物學報;2005年03期

相關(guān)會議論文 前10條

1 閆慧博;魯凱伍;金大地;江建明;;建立穩(wěn)定的大鼠脊髓全橫斷模型的實驗研究[A];第八屆全國脊柱脊髓損傷學術(shù)會議論文匯編[C];2007年

2 李翠娟;孫理軍;;對基于體質(zhì)的中醫(yī)證候動物模型制作的思考[A];中華中醫(yī)藥學會第七屆中醫(yī)體質(zhì)學術(shù)研討會論文集[C];2009年

3 張毅;付丹丹;古國民;霍小玲;;一種濕熱證Ⅰ型變態(tài)反應動物模型的研究[A];中華中醫(yī)藥學會皮膚科分會第四次學術(shù)年會;全國中醫(yī)、中西醫(yī)結(jié)合皮膚病診療新進展高級研修班論文集[C];2007年

4 陳雪功;李勇;;IgA腎病氣陰兩虛證動物模型的研制與方藥反證[A];中華中醫(yī)藥學會第九次中醫(yī)診斷學術(shù)會議論文集[C];2008年

5 吳昆e，

本文編號：1992202