本文選題：SA + 抗菌肽��； 參考：《醫(yī)學(xué)研究生學(xué)報(bào)》2014年07期

【摘要】：S100A7是一種小分子鈣結(jié)合蛋白,廣泛參與到上皮細(xì)胞的分化、皮膚化學(xué)防御體系的構(gòu)建、氧化應(yīng)激和炎癥反應(yīng)的發(fā)生等生命過程,其分泌可由物理、化學(xué)和生物等多方面因素誘導(dǎo)。S100A7具有多種結(jié)合配體,并通過特定的信號(hào)通路與活性氧類密切相關(guān)。作為皮膚的一種重要抗菌肽,S100A7能幫助人體表皮抵御常見致病微生物的侵襲。S100A7也在多種皮膚病中表達(dá)上調(diào),是反映皮膚細(xì)胞分化程度和炎癥狀態(tài)的關(guān)鍵指標(biāo)。另外,腦組織神經(jīng)元中S100A7的高表達(dá)可阻止阿爾茲海默癥患者腦中淀粉樣蛋白的沉積。S100A7在某些腫瘤組織中也呈現(xiàn)高表達(dá),與癌癥的發(fā)生和惡化密切相關(guān)。文中介紹S100A7的生物學(xué)特性及功能,總結(jié)S100A7在多種疾病中的表達(dá)特征和作用機(jī)制,為尋找S100A7相關(guān)疾病的分子標(biāo)記物和作用靶點(diǎn)提供新思路。
[Abstract]:S100A7 is a small molecule calcium binding protein, widely involved in epithelial cell differentiation, skin chemical defense system construction, oxidative stress and inflammatory reaction and other life processes, its secretion can be physical, S100A7 has multiple binding ligands induced by chemical and biological factors and is closely related to reactive oxygen species through specific signaling pathways. As an important antimicrobial peptide of skin, S100A7 can help human skin resist the invasion of common pathogenic microbes. S100A7 is also upregulated in many skin diseases, which is a key index to reflect the degree of differentiation and inflammation of skin cells. In addition, the high expression of S100A7 in brain neurons can prevent the deposition of amyloid protein S100A7 in brain of Alzheimer's disease patients, which is closely related to the occurrence and deterioration of cancer. This paper introduces the biological characteristics and functions of S100A7, summarizes the expression characteristics and mechanism of S100A7 in various diseases, and provides a new idea for finding molecular markers and targets of S100A7 related diseases.
【作者單位】： 西安交通大學(xué)生命學(xué)院生物信息學(xué)中心線粒體生物醫(yī)學(xué)研究所;
【基金】：國家自然科學(xué)基金(31370844)
【分類號(hào)】：R363
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本文編號(hào)：1974295